15,670 research outputs found
Multiobjective gas turbine engine controller design using genetic algorithms
This paper describes the use of multiobjective genetic algorithms (MOGAs) in the design of a multivariable control system for a gas turbine engine. The mechanisms employed to facilitate multiobjective search with the genetic algorithm are described with the aid of an example. It is shown that the MOGA confers a number of advantages over conventional multiobjective optimization methods by evolving a family of Pareto-optimal solutions rather than a single solution estimate. This allows the engineer to examine the trade-offs between the different design objectives and configurations during the course of an optimization. In addition, the paper demonstrates how the genetic algorithm can be used to search in both controller structure and parameter space thereby offering a potentially more general approach to optimization in controller design than traditional numerical methods. While the example in the paper deals with control system design, the approach described can be expected to be applicable to more general problems in the fields of computer aided design (CAD) and computer aided engineering (CAE
Metamodelling of multivariable engine models for real-time flight simulation.
Sophisticated real-time distributed flight simulation environments may be constructed from a wide range of modelling and simulation tools. In this way accuracy, detail and model flexibility may be incorporated into the simulator. Distributed components may be constructed by a wide range of methods, from high level environments such as Matlab, through coded environments such as C or Fortran to hardware-in-the- loop. In this paper the Response Surface Methodology is combined with a hyper-heuristic (evolutionary algorithm) and applied to the representation of computationally intensive non-linear multivariable engine modelling. The paper investigates the potential for metamodelling (models of models) dynamic models which were previously too slow to be included in multi-component, high resolution real-time simulation environments. A multi-dimensional gas turbine model with five primary control inputs, six environmental inputs and eleven outputs is considered. An investigation has been conducted to ascertain to what extent these systems can be approximated by response surfaces with experiments which have been designed by hyper-heuristics as a first step towards automatic modelling methodology
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Power in management and organization science
This paper reviews and evaluates the concept of power in management and organization science. In order to organize the extant literature on this topic, we develop a framework that identifies four faces of power (i.e. coercion, manipulation, domination, and subjectification) and four sites of power (i.e. power enacted “in”, “through”, “over”, and “against” organizations). This allows us to evaluate assumptions both shared and contested in the field. Building on the review, the paper then points to potentially novel areas of research that may extend our understandings of organizational power in management and organization science
Particle dynamics inside shocks in Hamilton-Jacobi equations
Characteristics of a Hamilton-Jacobi equation can be seen as action
minimizing trajectories of fluid particles. For nonsmooth "viscosity"
solutions, which give rise to discontinuous velocity fields, this description
is usually pursued only up to the moment when trajectories hit a shock and
cease to minimize the Lagrangian action. In this paper we show that for any
convex Hamiltonian there exists a uniquely defined canonical global nonsmooth
coalescing flow that extends particle trajectories and determines dynamics
inside the shocks. We also provide a variational description of the
corresponding effective velocity field inside shocks, and discuss relation to
the "dissipative anomaly" in the limit of vanishing viscosity.Comment: 15 pages, no figures; to appear in Philos. Trans. R. Soc. series
Myosin VIIA is required for aminoglycoside accumulation in cochlear hair cells.
Myosin VIIA is expressed by sensory hair cells and has a primary structure predicting a role in membrane trafficking and turnover, processes that may underlie the susceptibility of hair cells to aminoglycoside antibiotics. [3H]Gentamicin accumulation and the effects of aminoglycosides were therefore examined in cochlear cultures of mice with different missense mutations in the myosin VIIA gene, Myo7a, to see whether myosin VIIA plays a role in aminoglycoside ototoxicity. Hair cells from homozygous mutant Myo7a(sh1) mice, with a mutation in a non-conserved region of the myosin VIIA head, respond rapidly to aminoglycoside treatment and accumulate high levels of gentamicin. Hair cells from homozygous mutant Myo7a(6J) mice, with a mutation at a highly conserved residue close to the ATP binding site of the myosin VIIA head, do not accumulate [3H]gentamicin and are protected from aminoglycoside ototoxicity. Hair cells from heterozygotes of both alleles accumulate [3H]gentamicin and respond to aminoglycosides. Although aminoglycoside uptake is thought to be via apical surface-associated endocytosis, coated pit numbers on the apical membrane of heterozygous and homozygous Myo7a(6J) hair cells are similar. Pulse-chase experiments with cationic ferritin confirm that the apical endocytotic pathway is functional in homozygous Myo7a(6J) hair cells. Transduction currents can be recorded from both heterozygous and homozygous Myo7a(6J) hair cells, suggesting it is unlikely that the drug enters via diffusion through the mechanotransducer channel. The results show that myosin VIIA is required for aminoglycoside accumulation in hair cells. Myosin VIIA may transport a putative aminoglycoside receptor to the hair cell surface, indirectly translocate it to sites of membrane retrieval, or retain it in the endocytotic pathway
Non-Markovian Dynamics and Entanglement of Two-level Atoms in a Common Field
We derive the stochastic equations and consider the non-Markovian dynamics of
a system of multiple two-level atoms in a common quantum field. We make only
the dipole approximation for the atoms and assume weak atom-field interactions.
From these assumptions we use a combination of non-secular open- and
closed-system perturbation theory, and we abstain from any additional
approximation schemes. These more accurate solutions are necessary to explore
several regimes: in particular, near-resonance dynamics and low-temperature
behavior. In detuned atomic systems, small variations in the system energy
levels engender timescales which, in general, cannot be safely ignored, as
would be the case in the rotating-wave approximation (RWA). More problematic
are the second-order solutions, which, as has been recently pointed out, cannot
be accurately calculated using any second-order perturbative master equation,
whether RWA, Born-Markov, Redfield, etc.. This latter problem, which applies to
all perturbative open-system master equations, has a profound effect upon
calculation of entanglement at low temperatures. We find that even at zero
temperature all initial states will undergo finite-time disentanglement
(sometimes termed "sudden death"), in contrast to previous work. We also use
our solution, without invoking RWA, to characterize the necessary conditions
for Dickie subradiance at finite temperature. We find that the subradiant
states fall into two categories at finite temperature: one that is temperature
independent and one that acquires temperature dependence. With the RWA there is
no temperature dependence in any case.Comment: 17 pages, 13 figures, v2 updated references, v3 clarified results and
corrected renormalization, v4 further clarified results and new Fig. 8-1
A Mechanism for Ferrimagnetism and Incommensurability in One-Dimensional Systems
A mechanism for ferrimagnetism in
(1+1)-dimensions is discussed. The ferrimagnetism is cased by interactions
described by operators with non-zero conformal spin. Such interactions appear
in such problems as the problem of tunneling between Luttinger liquids and the
problem of frustrated spin ladder. I present exact solutions for a
representative class of models containing such interactions together with a
simple mean field analysis. It is shown that the interactions (i) dynamically
generate static oscillations with a wave vector dependent on the coupling
constant, (ii) give rise to a finite magnetic moment at accompanied by
the soft mode with a non-relativistic ({\it ferromagnetic}) dispersion , (iii) generate massive (roton) modes.Comment: replaced by the extended version, references adde
On the response surface methodology and designed experiments for computationally intensive distributed aerospace simulations
Distributed real-time simulation is the focus of intense development with complex systems being represented by individual component simulations interacting as a coherent model. Commercial off the shelf (COTS) and Freeware real-time software exists to provide data communication channels between he components subject to adequate system bandwidth. However, if the individual models are too computationally intensive to run in real-time, then the performance of the real-time simulation architecture is compromised.
In this paper, model representations are developed from dynamic simulation by the Response surface Methodology, allowing complex systems to be included in a real-time environment. A Permanent Magnet AC motor drive simulation with model reference control for a more electric aircraft application is examined as a candidate for inclusion in a realtime simulation environment
Outbreak of acute hepatitis C following the use of anti-hepatitis C virus--screened intravenous immunoglobulin therapy
BACKGROUND and AIMS: Hepatitis C virus (HCV) infection has been associated with intravenous (IV) immunoglobulin (Ig), and plasma donations used to prepare IV Ig are now screened to prevent transmission. Thirty-six patients from the United Kingdom received infusions from a batch of anti-HCV antibody-screened intravenous Ig (Gammagard; Baxter Healthcare Ltd., Thetford, Norfolk, England) that was associated with reports of acute hepatitis C outbreak in Europe. The aim of this study was to document the epidemiology of this outbreak. METHODS: Forty-six patients from the United Kingdom treated with Gammagard (34 exposed and 12 unexposed to the batch) returned epidemiological questionnaires. RESULTS: Eighty-two percent of the exposed patients (28 of 34) became positive for HCV RNA. Eighteen percent of the patients (6 of 34) who had infusions with this batch tested negative for HCV RNA, but 2 of the patients had abnormal liver function and subsequently seroconverted to anti-HCV antibody positive. Twenty-seven percent of the patients (9 of 34) developed jaundice, and 79% (27 of 34) had abnormal liver transferase levels. Virus isolates (n=21), including an isolate from the implicated batch, were genotype 1a and virtually identical by sequence analysis of the NS5 region, consistent with transmission from a single source. CONCLUSIONS: Hepatitis C infection can be transmitted by anti-HCV-screened IV Ig. Careful documentation of IV Ig batch numbers and regular biochemical monitoring is recommended for all IV Ig recipients
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