DataSheet_1_Validating the efficacy and value proposition of mental fitness vocal biomarkers in a psychiatric population: prospective cohort study.docx

BackgroundThe utility of vocal biomarkers for mental health assessment has gained increasing attention. This study aims to further this line of research by introducing a novel vocal scoring system designed to provide mental fitness tracking insights to users in real-world settings.MethodsA prospective cohort study with 104 outpatient psychiatric participants was conducted to validate the “Mental Fitness Vocal Biomarker” (MFVB) score. The MFVB score was derived from eight vocal features, selected based on literature review. Participants’ mental health symptom severity was assessed using the M3 Checklist, which serves as a transdiagnostic tool for measuring depression, anxiety, post-traumatic stress disorder, and bipolar symptoms.ResultsThe MFVB demonstrated an ability to stratify individuals by their risk of elevated mental health symptom severity. Continuous observation enhanced the MFVB’s efficacy, with risk ratios improving from 1.53 (1.09-2.14, p=0.0138) for single 30-second voice samples to 2.00 (1.21-3.30, p=0.0068) for data aggregated over two weeks. A higher risk ratio of 8.50 (2.31-31.25, p=0.0013) was observed in participants who used the MFVB 5-6 times per week, underscoring the utility of frequent and continuous observation. Participant feedback confirmed the user-friendliness of the application and its perceived benefits.ConclusionsThe MFVB is a promising tool for objective mental health tracking in real-world conditions, with potential to be a cost-effective, scalable, and privacy-preserving adjunct to traditional psychiatric assessments. User feedback suggests that vocal biomarkers can offer personalized insights and support clinical therapy and other beneficial activities that are associated with improved mental health risks and outcomes.</p

Construction of a biological rhythm assessment scale for children

<div><p>Abstract Introduction Biological rhythm is associated with the level of alertness, cognitive performance and mood of the individuals. Its regularity is essential to preserve good health and quality of life. Objective To present the steps for the construction of the scale entitled Biological Rhythm Interview of Assessment in Neuropsychiatry – Kids (BRIAN-K), designed to measure biological rhythm disruptions in Brazilian children and adolescents. Methods Items were developed following the adult version of the scale. Analysis of the psychometric characteristics of the scale was based on the responses of 373 parents/caregivers of school age children (7 and 8 years old). Results A theoretical model of 17 items with the purpose of evaluating four domains (sleep, activities, social rhythm and eating pattern) was determined using exploratory factor analysis (EFA) and via identification of a general factor. The psychometric properties of the BRIAN-K showed favorable properties. Conclusion Only two items needed to be rewritten. Further studies are needed to investigate the instrument's adequacy to different age groups and additional evidence of validity and reliability.</p></div

Demographic, functioning, quality of life, intellectual ability and clinical characteristics.

a<p>Chi-square test; ^b independent t-test; ^c Mann-Whitney test.</p>*<p>p<0.05.</p><p>YMRS: Young Mania Rating Scale; HAM-D: Hamilton Depression Rating Scale; FAST: Functional Assessment Screening Tool; SWLS: Satisfaction With Life Scale.</p

Social Networking Online and Offline in BD patients.

<p><b>A</b>. The Facebook number of friends (FBN) in patients and controls. <b>B</b>. The social networking number or lifetime total number of friends (SNN) in patients and controls.</p