9 research outputs found
Genetic variability in the 5' UTR and NS5A regions of hepatitis C virus RNA isolated from non-responding and responding patients with chronic HCV genotype 1 infection
Genetic variability in the 5' UTR and NS5A regions of hepatitis C virus RNA isolated from non-responding and responding patients with chronic HCV genotype 1 infection
Sequence variation among different hepatitis C virus (HCV) isolates has
adaptive significance and reflects the modes and intensities of
selection mechanisms operating on the virus. In this work, we sought to
investigate using classical population genetics parameters, the genetic
variability of HCV genotype 1 using the 5' UTR and NS5A regions from
treatment non-responding and responding groups of patients. Both
regions showed low genetic varia-bility and the 5' UTR showed neutral
deviation. No differences were observed in the nonsynonymous/synonymous
nucleotide substitution ratio among groups for NS5A. The analysis of
molecular variance test of the 5' UTR region showed an 11.94% variation
among groups. Phylogenetic analysis showed no correlation between
sequence variations and therapeutic responses