Left Ventricular Dilation and Pulmonary Vasodilatation after Surgical Shunt for Treatment of Pre-Sinusoidal Portal Hypertension

<div><p>Objective</p><p>The aim of this study was to prospectively investigate the long-term cardiovascular and pulmonary hemodynamic effects of surgical shunt for treatment of portal hypertension (PH) due to <i>Schistosomiasis mansoni</i>.</p><p>Location</p><p>The University of São Paulo Medical School, Brazil; Public Practice.</p><p>Methods</p><p>Hemodynamic evaluation was performed with transesophageal Doppler and contrast-enhanced echocardiography (ECHO) on twenty-eight participants with schistosomal portal hypertension. Participants were divided into two groups according to the surgical procedure used to treat their schistosomal portal hypertension within the last two years: group 1—distal splenorenal shunt (DSRS, n = 13) and group 2—esophagogastric devascularization and splenectomy (EGDS, n = 15).</p><p>Results</p><p>The cardiac output (5.08 ± 0.91 L/min) and systolic volume (60.1 ± 5.6 ml) were increased (p = 0.001) in the DSRS group. DSRS participants had a significant increase (p < 0.0001) in their left ventricular end-systolic and end-diastolic diameters as well as in their left ventricular end-diastolic and end-systolic volumes (p < 0.001) compared with the preoperative period. No statistically significant difference was found in the patients who underwent EGDS. ECHO revealed intrapulmonary vasodilatation (IPV) in 18 participants (64%), 9 DSRS and 9 EGDS (p > 0.05).</p><p>Conclusions</p><p>The late increase in the cardiac output, stroke volume and left ventricular diameters demonstrated left ventricular dilatation after a distal splenorenal shunt. ECHO revealed a greater prevalence for IPV in patients with schistosomiasis than has previously been described in patients with PH from liver cirrhosis.</p></div

Late postoperative hemodynamic parameters in participants with portal hypertension due to hepatosplenic mansonic schistosomiasis.

<p>Late postoperative hemodynamic parameters in participants with portal hypertension due to hepatosplenic mansonic schistosomiasis.</p

Laboratory data of the participants with hepatosplenic schistosomiasis mansoni after surgical treatment for portal hypertension by distal splenorenal shunt (DSRS) and esophagogastric devascularization with splenectomy (EGDS).

<p>Laboratory data of the participants with hepatosplenic schistosomiasis mansoni after surgical treatment for portal hypertension by distal splenorenal shunt (DSRS) and esophagogastric devascularization with splenectomy (EGDS).</p