Making Sense Out of Information Chaos

Support centers have been overrun by information. Categorization and cataloging have failed to help us keep up. A new method is required. As we have entered the age of data we need a more human aspect to our training, knowledge management and day to day assessing of knowledge. This paper discusses practical learning ideas and key ideas such as the Pie Principle, socialization of knowledge and information bubbles

Gerald Barry

Gerald Barry (b 1952) Biography, List of Compositions, Bibliograph

On constructing a sonic gangbang: system and subversion in Gerald Barry’s Chevaux-de-frise

This paper examines Chevaux-de-frise by Gerald Barry. The work is from a transitional period in Barry\u27s work forming a bridge between the work of the 1980s (most notably The Intelligence Park) and the more polyphonic work of the 1990s. The paper describes Barry\u27s use of canonic devices and his manipulation of found material before making some brief links to later works from Barry\u27s output

Evidence For The Involvement Of Runx1 And Runx2 In Maintenance Of The Breast Cancer Stem Cell Phenotype

In the United States, metastatic breast cancer kills approximately 40,000 women and 400 men annually, and approximately 200,000 new cases of breast cancer are diagnosed each year. Worldwide, breast cancer is the leading cause of cancer deaths among women. Despite advances in the detection and treatment of metastatic breast cancer, mortality rates from this disease remain high because the fact is that once metastatic, it is virtually incurable. It is widely accepted that a major reason breast cancer continues to exhibit recurrence after remission is that current therapies are insufficient for targeting and eliminating therapy-resistant cancer cells. Emerging research has demonstrated that these therapy-resistant cells possess stem cell-like properties and are therefore commonly referred to as breast cancer stem cells (BCSCs). A major hallmark of BCSCs is the cell surface expression of CD44 and lack of expression of CD24, the so-called CD24-/CD44+ phenotype. Research indicates that this dangerous and rare subpopulation of BCSCs may be responsible for cancer onset, recurrence, and ultimately metastasis that leads to death. Two different model systems were utilized in this research. The first was the MCF7 cell line, a luminal A tumor subtype representative of a mildly invasive breast ductal carcinoma with an ER+/PR+/-/HER2- immunoprofile. The second was the MCF10A breast cancer progression model, which consists of three cell lines: MCF10A, MCF10AT1, and MCF10CA1a. In this system, spontaneously immortalized, non-malignant MCF10A cells were transfected with constitutively active H-Ras to form pre-malignant MCF10AT1 cells, which were then subcutaneously injected into mice and allowed to metastasize in order to form the oncogenic MCF10ACA1a cell line. This thesis presents evidence of a CD24low/-/CD44+ BCSC subpopulation within the MCF10A breast cancer progression model system. Findings indicate that RUNX1 and RUNX2 expression levels are involved in maintaining the BCSC phenotype. Across two different model systems, qRT-PCR analysis revealed that decreased levels of RUNX1 expression and increased levels of RUNX2 expression are essential for the maintenance of the BCSC subpopulation. It was also shown that low expression levels of RUNX1 and high expression levels of RUNX2 are present in CD24low/-/CD44+ BCSCs as compared to CD24+/CD44+ non-BCSCs. Furthermore, shRNA knockdown of RUNX1 was shown to enhance tumorigenicity, while shRNA knockdown of RUNX2 repressed tumorigenicity in BCSCs, as measured by the tumorsphere-formation assay. This research lays the groundwork for future investigations into the roles of RUNX1 and RUNX2 in regulating stemness in breast cancer

Inventing identities: The case of Frederick May

This chapter examines how Frederick May has been depicted in previous musicological literature and the ways in which both biographical facts and May’s music have been misrepresented in an attempt to create the impression that he was part of the main stream of central European modernism. The article uncovers new material regarding the early stages of May’s career and demonstrates that May’s educational trajectory was similar to other pupils of Vaughan Williams. The article counters the narrative of failure created by musicologists who judge May for failing to achieve aesthetic aims that he never set out to attain and reflects the point which research on May had reached at the time of writing. It therefore forms a precursor to the later article on May by Mark Fitzgerald ‘Retrieving the Real Frederick May’, Journal of the Society for Musicology in Ireland, 14 (2019) 31-73. DOI: 10.35561/JSMI1419

Mogu and the Unicorn: Frederick May\u27s Music for the Gate Theatre

This chapter addresses the contributions that Frederick May (1911-85) made to the Gate\u27s productions of Padraic Colum\u27s Mogu of the Desert (1931) and Denis Johnston\u27s A Bride for the Unicorn (1933). As a young gay Irishman, May had to navigate a cultural infrastructure in which opportunities for composers were scarce, but at the Gate he was given the chance to develop his talents in a new field, as well as to experiment with musical forms in a high-profile setting

\u27...sometimes the actual sound of the voice is my own\u27: an interview with Garrett Sholdice

This interview surveys the music of Garrett Sholdice, discusses influences and traces aspects of Sholdice\u27s aesthetic and technical approach

Retrieving the Real Frederick May

Although Frederick May (1911–85) is seen as holding an important position in the history of twentieth-century composition in Ireland, writing about May has been sporadic. There exists no serious biographical study to date and most of the commentary on the music has been superficial and frequently misleading. Utilizing the recently re-catalogued collection of May’s manuscripts in the Manuscripts and Archives Research Library in Trinity College Dublin (TCD) and also libraries and public collections in Cork, the United States, London, the Czech Republic and Vienna as well as a number of private archives, this essay attempts to build a clearer picture of Frederick May. It also clarifies May’s position on a number of issues that have been misrepresented or omitted in the literature to date. This essay aims to provide a more reliable basis from which future studies of May’s music and the development of his style can draw

A belated arrival: the delayed acceptance of musical modernity in Irish composition

The chronic lack of investment in the capital needed to foster the development of music during the period of colonial governance in Ireland and the early years of the Free State, combined with Ireland’s peripheral position in relation to the centres of musical modernism, resulted in composers in Ireland adopting modernist ideas at a very late stage, particularly in comparison with the chronology of Irish literary modernism. Previous literature on the subject of Irish musical modernism has frequently obscured any clear sense of the real extent of this delay through the conflation of the concept of “modernism” with styles that may have been perceived by Irish contemporaries as “modern” at a particular historical juncture. This essay surveys the work of the key figures of twentieth-century Irish composition, examining the degree to which they may or may not have been interested in or engaged by international ideas of modernism. It re-evaluates composers frequently regarded as modernist in the literature such as Frederick May, Brian Boydell and Seán Ó Riada; discusses the important of Seóirse Bodley’s work from the 1960s; and posits the idea of an Irish avant-garde emerging in the 1970s. The essay concludes by noting the continued relevance of modernist ideas for a number of today’s composers

Frederick May Songs

This volume gathers together Frederick May\u27s surviving songs in a new performing edition with a commentary by the editor. Individual string parts for the Four Romantic Songs are available from the editor