Serum creatine kinase isoenzymes in children with osteogenesis imperfecta

This study evaluates serum creatine kinase isoenzyme activity in children with osteogenesis imperfecta to determine its usefulness as a biochemical marker during treatment with bisphosphonate. The changes of creatine kinase (CK) isoenzyme activity during and after discontinuation therapy were observed. These results could be useful in addressing over-treatment risk prevention. Introduction The brain isoenzyme of creatine kinase (CKbb) is highly expressed in mature osteoclasts during osteoclastogenesis, thus plays an important role in bone resorption. We previously identified high serum CKbb levels in 18 children with osteogenesis imperfect (OI) type 1 treated for 1 year with bisphosphonate (neridronate). In the present study, serum CK isoenzymes were evaluated in the same children with continuous versus discontinued neridronate treatment over a further 2-year follow-up period. Methods This study included 18 children with OI type 1, 12 with continued (group A) and 6 with ceased (group B) neridronate treatment. Auxological data, serum biochemical markers of bone metabolism, bone mineral density z-score, and serum total CK and isoenzyme activities were determined in both groups. Results Serum CKbb was progressively and significantly increased in group A (p < 0.004) but rapidly decreased to undetectable levels in group B. In both groups, the cardiac muscle creatine kinase isoenzyme (CKmb) showed a marked decrease, while serum C-terminal telopeptide (CTx) levels were almost unchanged. Conclusions This study provides evidence of the cumulative effect of neridronate administration in increasing serum CKbb levels and the reversible effect after its discontinuation. This approach could be employed for verifying the usefulness of serum CKbb as a biochemical marker in patients receiving prolonged bisphosphonate treatment. Moreover, the decreased serum CKmb levels suggest a systemic effect of these drugs

Silicon detectors for the n-TOF neutron beams monitoring

During 2014 the second experimental area EAR2 was completed at the n-TOF neutron beam facility at CERN. As the neutrons are produced via spallation, by means of a high-intensity 20 GeV pulsed proton beam impinging on a thick target, the resulting neutron beam covers an enormous energy range, from thermal to several GeV. In this paper we describe two beam diagnostic devices, designed and built at INFN-LNS, both exploiting silicon detectors coupled with neutron converter foils containing 6Li. The first one is based on four silicon pads and allows to monitor the neutron beam flux as a function of the neutron energy. The second one, based on position sensitive silicon detectors, is intended for the reconstruction of the beam profile, again as a function of the neutron energy. Several electronic setups have been explored in order to overcome the issues related to the gamma flash, namely a huge pulse present at the start of each neutron bunch which may blind the detectors for some time. The two devices have been characterized with radioactive sources at INFN-LNS and then tested at n-TOF. The wide energy and intensity range they proved capable of sustaining, made them quite attractive and suitable to be used in both EAR1 and EAR2 n-TOF experimental areas, where they became immediately operational.Comment: submitted to Review of Scientific Instrument

A mini-phoswich scintillator as a possible stop detector for the NUMEN project

AbstractIn the framework of the NUMEN project, aimed at the investigation of the nuclear matrix elements connected to the neutrinoless double beta decay by means of the Double Charge Exchange nuclear reactions (Cappuzzello et al., 2015), a high granularity stop detector for heavy ions is needed. It has to allow the identification of ions up to Z≈10 while maintaining a total energy resolution around 2%. As the use of silicon detectors is not possible, due to their poor radiation hardness, scintillators are being investigated as possible candidates. In this paper we show a promising result obtained using a plastic+inorganic phoswich scintillator readout by means of a Silicon Photo Multiplier

Nutritional interventions for patients with melanoma: From prevention to therapy—an update

Melanoma is an aggressive skin cancer, whose incidence rates have increased over the past few decades. Risk factors for melanoma are both intrinsic (genetic and familiar predisposition) and extrinsic (environment, including sun exposure, and lifestyle). The recent advent of targeted and immune-based therapies has revolutionized the treatment of melanoma, and research is focusing on strategies to optimize them. Obesity is an established risk factor for several cancer types, but its possible role in the etiology of melanoma is controversial. Body mass index, body surface area, and height have been related to the risk for cutaneous melanoma, although an ‘obesity paradox’ has been described too. Increasing evidence suggests the role of nutritional factors in the prevention and management of melanoma. Several studies have demonstrated the impact of dietary attitudes, specific foods, and nutrients both on the risk for melanoma and on the progression of the disease, via the effects on the oncological treatments. The aim of this narrative review was to summarize the main literature results regarding the preventive and therapeutic role of nutritional schemes, specific foods, and nutrients on melanoma incidence and progression

A Robotic arm for optical and gamma radwaste inspection

We propose Radibot, a simple and cheap robotic arm for remote inspection, which interacts with the radwaste environment by means of a scintillation gamma detector and a video camera representing its light (< 1 kg) payload. It moves vertically thanks to a crane, while the other three degrees of freedom are obtained by means of revolute joints. A dedicated algorithm allows to automatically choose the best kinematics in order to reach a graphically selected position, while still allowing to fully drive the arm by means of a standard videogame joypad