2,888 research outputs found
Making gas-CCS a commercial reality: The challenges of scaling up
Significant reductions in CO2 emissions are required to limit the global temperature rise to
2°C. Carbon capture and storage (CCS) is a key enabling technology that can be applied to power
generation and industrial processes to lower their carbon intensity. There are, however, several
challenges that such a method of decarbonization poses when used in the context of natural gas
(gas-CCS), especially for solvent-based (predominantly amines) post-combustion capture. These are
related to: (i) the low CO2 partial pressure of the exhaust gases from gas-fired power plants (3-4%vol.
CO2), which substantially limits the driving force for the capture process; (ii) their high O2 concentration
(12-13%vol. O2), which can degrade the capture media via oxidative solvent degradation; and (iii)
their high volumetric flow rates, which means large capture plants are needed. Such post-combustion
gas-CCS features unavoidably lead to increased CO2 capture costs. This perspective aims to
summarize the key technologies used to overcome these as a priority, including supplementary firing,
humidified systems, exhaust gas recirculation and selective exhaust gas recirculation. These focus on
the maximum CO2 levels achievable for each, as well as the electrical efficiencies attainable when the
capture penalty is taken into account. Oxy-turbine cycles are also discussed as an alternative to
post-combustion gas-CCS, indicating the main advantages and limitations of these systems together
with the expected electrical efficiencies. Furthermore, we consider the challenges for scaling-up and
deployment of these technologies at a commercial level to enable gas-CCS to play a crucial role in a
low-carbon future
Multidisciplinary interventions for multisite osteoarthritis in primary care: a systematic review
Demonstration of vincristine resistance in primary intestinal neoplasms in the rat by the 'post-metaphase index'.
A method is described enabling the direct measurement of vincristine resistance in intact tissues in vivo by morphological study. Using the metaphase arresting properties of the drug, counts were made of escaping anaphase and telophase mitotic figures at a range of doses. The proportion of post-metaphase mitotic figures is called the post-metaphase index (PMI). In 95 primary intestinal tumours induced by dimethylhydrazine (DMH) in rats, an increase in resistance to vincristine was shown over normal mucosa (P less than 0.001). The data were analysed by computer modelling and a linear relationship is demonstrated between the logit of the post-metaphase index, and log dose of vincristine. To achieve a PMI of 1% the fitted lines show an enhanced vincristine dose requirement over normal mucosa of 6 times in colonic tumours, and 8 times in small intestinal tumours. Non-neoplastic mucosa from the DMH-treated animals requires an enhanced dose of vincristine of 1.5 times, compared with normal mucosa, to achieve a PMI of 1%. Given current interest in the mechanism of vincristine resistance in cell lines this new approach provides a technique for assessing the resistance of solid tumours, both in vivo and in vitro, and for subsequent experimental manipulation
An Analysis of the Parasites of a Mid-winter Population of the Snowshoe Hare, Lepus americanus, on Insular Newfoundland During a Cyclical Peak
A mid-winter sample of 78 Snowshoe Hares (Lepus americanus) was collected during their cyclical peak in population from three eco-regions (Western Newfoundland, North Shore and Avalon Forest) on insular Newfoundland and was examined for the presence of enteric parasites. The length of the hares was significantly shorter in the Avalon Forest Region (n = 27) than those of the Western Newfoundland Region (n = 25) and North Shore Region (n = 26) samples (P ≤ 0.001 and P ≤ 0.003 respectively); however, no significant differences occurred for other morphological measurements. Four species of parasites, two cestodes (Mosgovoyia pectinata and Taenia pisiformis) and two nematodes (Obeliscoides cuniculi and Rauschia triangularis), were recovered. Taenia pisiformis was recovered from the North Shore eco-region only. No other significant differences with respect to their prevalence, intensity, mean intensity, relative density and dispersion between eco-regions were found. Within eco-regions, only R. triangularis showed a significantly higher value (P ≤ 0.027) for males and the prevalence of this species was lower than that previously reported. The occurrence of O. cuniculi was significantly different between the higher weight classes of hares and the prevalence of this species was higher than that previously reported. No trends for multiple infections were noted. The expansion of a new animal species, the Coyote, Canis latrans, to Newfoundland appeared to have had no effect on the diversity of parasites found in the hare
Verapamil sensitizes normal and neoplastic rodent intestinal tissues to the stathmokinetic effect of vincristine in vivo.
A morphological method has been developed allowing measurement of the effect on intestinal epithelia of vincristine. In routinely prepared tissue sections the proportion of mitotic events progressing beyond metaphase is counted by microscopy. When estimated over a range of doses of vincristine this post-metaphase index (PMI) can be used to compare the sensitivity of differing intact tissues. Intestinal tumours were induced in rats by chemical carcinogenesis. Administration of vincristine in the presence or absence of verapamil was performed in these tumour-bearing animals. Sections were prepared from colonic and small-bowel tumours and from normal mucosa. The results show that verapamil increases the sensitivity of the tissues studied to vincristine. A dose dependent effect of verapamil on vincristine sensitisation was demonstrated in colonic tissues. These findings indicate a shared pharmacological property between the resistance of primary tumour tissue and the multidrug-resistance phenotype
A PC parallel port button box provides millisecond response time accuracy under Linux
For psychologists, it is sometimes necessary to measure people's reaction times to the nearest millisecond. This article describes how to use the PC parallel port to receive signals from a button box to achieve millisecond response time accuracy. The workings of the parallel port, the corresponding port addresses, and a simple Linux program for controlling the port are described. A test of the speed and reliability of button box signal detection is reported. If the reader is moderately familiar with Linux, this article should provide sufficient instruction for him or her to build and test his or her own parallel port button box. This article also describes how the parallel port could be used to control an external apparatus
You Can't Get There From Here: Hubble Relaxation in the Local Volume
A beginning end-point for galaxy motions within the 10-Mpc Local Volume is
constructed by requiring a smooth distribution of (luminous) mass at the time
of recombination, which is shown to be equivalent to a smooth Hubble flow at
early times. It is found, by this purely kinematical method, that present
peculiar motions are too small by a factor of at least several (and largely in
the wrong direction) to have produced the observed structures within the age of
the universe. Known dynamical effects are inadequate to remove the discrepancy.
This result is different in origin from previously known ``cold flow''
problems. The simple dynamical picture often used within the Local Volume (for
instance, in deriving masses through calculation of a zero-velocity surface) is
thus called into question. The most straightforward explanation (though not the
only possible) is that there exists a large quantity of baryonic matter in this
region so far undetected, and unassociated with galaxies or groups.Comment: 23 pages, accepted by the Astronomical Journa
Exclusions for resolving urban badger damage problems: Outcomes and consequences
Increasing urbanisation and growth of many wild animal populations can result in a greater frequency of human-wildlife conflicts. However, traditional lethal methods of wildlife control are becoming less favoured than non-lethal approaches, particularly when problems involve charismatic species in urban areas. Eurasian badgers (Meles meles) excavate subterranean burrow systems (setts), which can become large and complex. Larger setts within which breeding takes place and that are in constant use are known as main setts. Smaller, less frequently occupied setts may also exist within the social group's range. When setts are excavated in urban environments they can undermine built structures and can limit or prevent safe use of the area by people. The most common approach to resolving these problems in the UK is to exclude badgers from the problem sett, but exclusions suffer a variable success rate. We studied 32 lawful cases of badger exclusions using one-way gates throughout England to evaluate conditions under which attempts to exclude badgers from their setts in urban environments were successful. We aimed to identify ways of modifying practices to improve the chances of success. Twenty of the 32 exclusion attempts were successful, but success was significantly less likely if a main sett was to be excluded in comparison with another type of sett and if vegetation was not completely removed from the sett surface prior to exclusion attempts. We recommend that during exclusions all vegetation is removed from the site, regardless of what type of sett is involved, and that successful exclusion of badgers from a main sett might require substantially more effort than other types of sett
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