10,923 research outputs found
CoA protects against the deleterious effects of caloric overload in Drosophila
We developed a Drosophila model of T2D in which high sugar (HS) feeding leads to insulin resistance. In this model, adipose TG storage is protective against fatty acid toxicity and diabetes. Initial biochemical and gene expression studies suggested that deficiency in CoA might underlie reduced TG synthesis in animals during chronic HS feeding. Focusing on the Drosophila fat body (FB), which is specialized for TG storage and lipolysis, we undertook a series of experiments to test the hypothesis that CoA could protect against the deleterious effects of caloric overload. Quantitative metabolomics revealed a reduction in substrate availability for CoA synthesis in the face of an HS diet. Further reducing CoA synthetic capacity by expressing FB-specific RNAi targeting pantothenate kinase (PK orfumble) or phosphopantothenoylcysteine synthase (PPCS) exacerbated HS-diet-induced accumulation of FFAs. Dietary supplementation with pantothenic acid (vitamin B5, a precursor of CoA) was able to ameliorate HS-diet-induced FFA accumulation and hyperglycemia while increasing TG synthesis. Taken together, our data support a model where free CoA is required to support fatty acid esterification and to protect against the toxicity of HS diets
Development of digital computer program for thermal network correction. Phase 2 - Program development. Phase 3 - Demonstration/application Final report
Developing digital computer program for correcting soft parameters of thermal network by Kalman filtering metho
Development of a Radioimmunoassay for Hog Pancreatic Kallikrein and its Apllication in Pharmacological Studies
In vivo laser Doppler holography of the human retina
The eye offers a unique opportunity for non-invasive exploration of
cardiovascular diseases. Optical angiography in the retina requires sensitive
measurements, which hinders conventional full-field laser Doppler imaging
schemes. To overcome this limitation, we used digital holography to perform
laser Doppler perfusion imaging of the human retina in vivo with near-infrared
light. Wideband measurements of the beat frequency spectrum of optical
interferograms recorded with a 39 kHz CMOS camera are analyzed by short-time
Fourier transformation. Power Doppler images and movies drawn from the zeroth
moment of the power spectrum density reveal blood flows in retinal and
choroidal vessels over 512 512 pixels covering 2.4 2.4 mm
on the retina with a 13 ms temporal resolution.Comment: 5 pages, 5 figure
An intelligent tutoring system for the investigation of high performance skill acquisition
The issue of training high performance skills is of increasing concern. These skills include tasks such as driving a car, playing the piano, and flying an aircraft. Traditionally, the training of high performance skills has been accomplished through the use of expensive, high-fidelity, 3-D simulators, and/or on-the-job training using the actual equipment. Such an approach to training is quite expensive. The design, implementation, and deployment of an intelligent tutoring system developed for the purpose of studying the effectiveness of skill acquisition using lower-cost, lower-physical-fidelity, 2-D simulation. Preliminary experimental results are quite encouraging, indicating that intelligent tutoring systems are a cost-effective means of training high performance skills
Cavity QED with separate photon storage and qubit readout modes
We present the realization of a cavity quantum electrodynamics setup in which
photons of strongly different lifetimes are engineered in different harmonic
modes of the same cavity. We achieve this in a superconducting transmission
line resonator with superconducting qubits coupled to the different modes. One
cavity mode is strongly coupled to a detection line for qubit state readout,
while a second long lifetime mode is used for photon storage and coherent
quantum operations. We demonstrate sideband based measurement of photon
coherence, generation of n photon Fock states and the scaling of the sideband
Rabi frequency with the square root of n using a scheme that may be extended to
realize sideband based two-qubit logic gates.Comment: 4 pages, 5 figures, version with high resolution figures available at
http://qudev.ethz.ch/content/science/PubsPapers.htm
Time reversal in thermoacoustic tomography - an error estimate
The time reversal method in thermoacoustic tomography is used for
approximating the initial pressure inside a biological object using
measurements of the pressure wave made on a surface surrounding the object.
This article presents error estimates for the time reversal method in the cases
of variable, non-trapping sound speeds.Comment: 16 pages, 6 figures, expanded "Remarks and Conclusions" section,
added one figure, added reference
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