6,774 research outputs found
Deep Cover HCI
The growing popularity of methodologies that turn "to the wild" for real world data creates new ethical issues for the HCI community. For investigations questioning interactions in public or transient spaces, crowd interaction, or natural behaviour, uncontrolled and uninfluenced (by the experimenter) experiences represent the ideal evaluation environment. We argue that covert research can be completed rigorously and ethically to expand our knowledge of ubiquitous technologies. Our approach, which we call Deep Cover HCI, utilises technology-supported observation in public spaces to stage completely undisturbed experiences for evaluation. We complete studies without informed consent and without intervention from an experimenter in order to gain new insights into how people use technology in public settings. We argue there is clear value in this approach, reflect on the ethical issues of such investigations, and describe our ethical guidelines for completing Deep Cover HCI Research
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Ultrastructural Distribution of the 7 Nicotinic Acetylcholine Receptor Subunit in Rat Hippocampus
Acetylcholine (ACh) is an important neurotransmitter in the mammalian brain; it is implicated in arousal, learning, and other cognitive functions. Recent studies indicate that nicotinic receptors contribute to these cholinergic effects, in addition to the established role of muscarinic receptors. In the hippocampus, where cholinergic involvement in learning and memory is particularly well documented, 7 nicotinic acetylcholine receptor subunits (7 nAChRs) are highly expressed, but their precise ultrastructural localization has not been determined. Here, we describe the results of immunogold labeling of serial ultrathin sections through stratum radiatum of area CA1 in the rat. Using both anti-7 nAChR immunolabeling and -bungarotoxin binding, we find that 7 nAChRs are present at nearly all synapses in CA1 stratum radiatum, with immunolabeling present at both presynaptic and postsynaptic elements. Morphological considerations and double immunolabeling indicate that GABAergic as well as glutamatergic synapses bear 7 nAChRs, at densities approaching those observed for glutamate receptors in CA1 stratum radiatum. Postsynaptically, 7 nAChRs often are distributed at dendritic spines in a perisynaptic annulus. In the postsynaptic cytoplasm, immunolabeling is associated with spine apparatus and other membranous structures, suggesting that 7 nAChRs may undergo dynamic regulation, with insertion into the synapse and subsequent internalization. The widespread and substantial expression of 7 nAChRs at synapses in the hippocampus is consistent with an important role in mediating and/or modulating synaptic transmission, plasticity, and neurodegeneration
Assessing Human Error Against a Benchmark of Perfection
An increasing number of domains are providing us with detailed trace data on
human decisions in settings where we can evaluate the quality of these
decisions via an algorithm. Motivated by this development, an emerging line of
work has begun to consider whether we can characterize and predict the kinds of
decisions where people are likely to make errors.
To investigate what a general framework for human error prediction might look
like, we focus on a model system with a rich history in the behavioral
sciences: the decisions made by chess players as they select moves in a game.
We carry out our analysis at a large scale, employing datasets with several
million recorded games, and using chess tablebases to acquire a form of ground
truth for a subset of chess positions that have been completely solved by
computers but remain challenging even for the best players in the world.
We organize our analysis around three categories of features that we argue
are present in most settings where the analysis of human error is applicable:
the skill of the decision-maker, the time available to make the decision, and
the inherent difficulty of the decision. We identify rich structure in all
three of these categories of features, and find strong evidence that in our
domain, features describing the inherent difficulty of an instance are
significantly more powerful than features based on skill or time.Comment: KDD 2016; 10 page
The Bell Theorem as a Special Case of a Theorem of Bass
The theorem of Bell states that certain results of quantum mechanics violate
inequalities that are valid for objective local random variables. We show that
the inequalities of Bell are special cases of theorems found ten years earlier
by Bass and stated in full generality by Vorob'ev. This fact implies precise
necessary and sufficient mathematical conditions for the validity of the Bell
inequalities. We show that these precise conditions differ significantly from
the definition of objective local variable spaces and as an application that
the Bell inequalities may be violated even for objective local random
variables.Comment: 15 pages, 2 figure
Transverse Demagnetization Dynamics of a Unitary Fermi Gas
Understanding the quantum dynamics of strongly interacting fermions is a
problem relevant to diverse forms of matter, including high-temperature
superconductors, neutron stars, and quark-gluon plasma. An appealing benchmark
is offered by cold atomic gases in the unitary limit of strong interactions.
Here we study the dynamics of a transversely magnetized unitary Fermi gas in an
inhomogeneous magnetic field. We observe the demagnetization of the gas, caused
by diffusive spin transport. At low temperatures, the diffusion constant
saturates to the conjectured quantum-mechanical lower bound ,
where is the particle mass. The development of pair correlations,
indicating the transformation of the initially non-interacting gas towards a
unitary spin mixture, is observed by measuring Tan's contact parameter.Comment: 8 pages, 6 figures. Accepted versio
Bell inequalities as constraints on unmeasurable correlations
The interpretation of the violation of Bell-Clauser-Horne inequalities is
revisited, in relation with the notion of extension of QM predictions to
unmeasurable correlations. Such extensions are compatible with QM predictions
in many cases, in particular for observables with compatibility relations
described by tree graphs. This implies classical representability of any set of
correlations , , , and the equivalence of the
Bell-Clauser-Horne inequalities to a non void intersection between the ranges
of values for the unmeasurable correlation associated to different
choices for B. The same analysis applies to the Hardy model and to the "perfect
correlations" discussed by Greenberger, Horne, Shimony and Zeilinger. In all
the cases, the dependence of an unmeasurable correlation on a set of variables
allowing for a classical representation is the only basis for arguments about
violations of locality and causality.Comment: Some modifications have been done in order to improve clarity of
presentation and comparison with other approache
Inherited epidermolysis bullosa
Inherited epidermolysis bullosa (EB) encompasses a number of disorders characterized by recurrent blister formation as the result of structural fragility within the skin and selected other tissues. All types and subtypes of EB are rare; the overall incidence and prevalence of the disease within the United States is approximately 19 per one million live births and 8 per one million population, respectively. Clinical manifestations range widely, from localized blistering of the hands and feet to generalized blistering of the skin and oral cavity, and injury to many internal organs. Each EB subtype is known to arise from mutations within the genes encoding for several different proteins, each of which is intimately involved in the maintenance of keratinocyte structural stability or adhesion of the keratinocyte to the underlying dermis. EB is best diagnosed and subclassified by the collective findings obtained via detailed personal and family history, in concert with the results of immunofluorescence antigenic mapping, transmission electron microscopy, and in some cases, by DNA analysis. Optimal patient management requires a multidisciplinary approach, and revolves around the protection of susceptible tissues against trauma, use of sophisticated wound care dressings, aggressive nutritional support, and early medical or surgical interventions to correct whenever possible the extracutaneous complications. Prognosis varies considerably and is based on both EB subtype and the overall health of the patient
Asymptotic and intermediate long-time behavior of nuclear free induction decays in polycrystalline solids and powders
Free induction decay (FID) measured by nuclear magnetic resonance (NMR) in a
polycrystalline solid is the isotropic average of the FIDs for individual
single crystallites. It has been recently proposed theoretically and verified
experimentally that the long-time behavior of single-crystal FIDs has the
universal form of exponentially decaying sinusoidal oscillations.
Polycrystalline averaging complicates the situation theoretically, while the
available experimental evidence is also ambiguous. Exponentially decaying
sinusoidal oscillations have been observed for Xe-129 in polycrystalline solid
xenon but not for F-19 in the powder of CaF2. In this paper, we present the
first principles FID calculations for the powders of both CaF2 and solid xenon.
In both cases, the asymptotic long-time behavior has the expected form of
exponentially decaying sinusoidal oscillations, which is determined by the
single crystallite FID with the slowest exponential decay. However, this
behavior appears only at rather small values of the signal that have not yet
been measured in experiments. At intermediate times accessible experimentally,
a polycrystalline FID depends on the distribution of the exponential decay
constants and oscillation frequencies for single crystallite FIDs. In CaF2,
these parameters are relatively broadly distributed, and as a result, the
sinusoidal long-time oscillations become somewhat washed out. In contrast, the
single crystallite parameters are more clustered in solid xenon, and, as a
result, the experimentally observable range is characterized by well-defined
oscillation frequency and exponential decay constant even though both of these
parameters do not represent the true long-time behavior. The above difference
of the intermediate FID behavior originates from the difference of the crystal
structures of solid xenon and CaF2.Comment: 16 pages, 5 figure
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