555 research outputs found
Civil Procedure—Specific Exceptions to Charge Needed to Raise Points on Appeal
Lobalzo v. Varoli, 422 Pa. 5, 220 A.2d 634 (1966)
Key Residues Defining the Μ-Opioid Receptor Binding Pocket: A Site-Directed Mutagenesis Study
Structural elements of the rat Μ-opioid receptor important in ligand receptor binding and selectivity were examined using a site-directed mutagenesis approach. Five single amino acid mutations were made, three that altered conserved residues in the Μ, Δ, and Κ receptors (Asn 150 to Ala, His 297 to Ala, and Tyr 326 to Phe) and two designed to test for Μ/Δ selectivity (Ile 198 to Val and Val 202 to Ile). Mutation of His 297 in transmembrane domain 6 (TM6) resulted in no detectable binding with [ 3 H]DAMGO ( 3 H-labeled d-Ala 2 , N -Me-Phe 4 ,Gly-ol 5 -enkephalin), [ 3 H]bremazocine, or [ 3 H]ethylketocyclazocine. Mutation of Asn 150 in TM3 produces a three- to 20-fold increase in affinity for the opioid agonists morphine, DAMGO, fentanyl, Β-endorphin 1–31 , JOM-13, deltorphin II, dynorphin 1–13 , and U50,488, with no change in the binding of antagonists such as naloxone, naltrexone, naltrindole, and nor-binaltorphamine. In contrast, the Tyr 326 mutation in TM7 resulted in a decreased affinity for a wide spectrum of Μ, Δ, and Κ agonists and antagonists. Altering Val 202 to Ile in TM4 produced no change on ligand affinity, but Ile 198 to Val resulted in a four- to fivefold decreased affinity for the Μ agonists morphine and DAMGO, with no change in the binding affinities of Κ and Δ ligands.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65474/1/j.1471-4159.1997.68010344.x.pd
Truthmakers and modality
This paper attempts to locate, within an actualist ontology, truthmakers for modal truths: truths of the form or . In section 1 I motivate the demand for substantial truthmakers for modal truths. In section 2 I criticise Armstrong’s account of truthmakers for modal truths. In section 3 I examine essentialism and defend an account of what makes essentialist attributions true, but I argue that this does not solve the problem of modal truth in general. In section 4 I discuss, and dismiss, a theistic account of the source of modal truth proposed by Alexander Pruss. In section 5 I offer a means of (dis)solving the problem
In defense of the epistemic view of quantum states: a toy theory
We present a toy theory that is based on a simple principle: the number of
questions about the physical state of a system that are answered must always be
equal to the number that are unanswered in a state of maximal knowledge. A wide
variety of quantum phenomena are found to have analogues within this toy
theory. Such phenomena include: the noncommutativity of measurements,
interference, the multiplicity of convex decompositions of a mixed state, the
impossibility of discriminating nonorthogonal states, the impossibility of a
universal state inverter, the distinction between bi-partite and tri-partite
entanglement, the monogamy of pure entanglement, no cloning, no broadcasting,
remote steering, teleportation, dense coding, mutually unbiased bases, and many
others. The diversity and quality of these analogies is taken as evidence for
the view that quantum states are states of incomplete knowledge rather than
states of reality. A consideration of the phenomena that the toy theory fails
to reproduce, notably, violations of Bell inequalities and the existence of a
Kochen-Specker theorem, provides clues for how to proceed with this research
program.Comment: 32 pages, REVTEX, based on a talk given at the Rob Clifton Memorial
Conference, College Park, May 2003; v2: minor modifications throughout,
updated reference
First Report of a Novel Hepatozoon sp. in Giant Pandas (Ailuropoda melanoleuca)
The first report of giant pandas (Ailuropoda melanoleuca) infected with a novel Hepatozoon species is presented. An intraleukocytic parasite was detected via routine blood smear from a zoo-housed giant panda at the National Zoological Park. Ribosomal DNA sequences indicated a previously undescribed Hepatozoon species. Phylogenetic and distance analyses of the sequences placed it within its own branch, clustered with Old World species with carnivore (primarily ursid and mustelid) hosts. Retrospective and opportunistic testing of other individuals produced additional positive detections (17/23, 73.9%), demonstrating 100% prevalence (14/14) across five institutions. All animals were asymptomatic at time of sampling, and health implications for giant pandas remain unknown
Slow relaxation in the two dimensional electron plasma under the strong magnetic field
We study slow relaxation processes in the point vortex model for the
two-dimensional pure electron plasma under the strong magnetic field. By
numerical simulations, it is shown that, from an initial state, the system
undergoes the fast relaxation to a quasi-stationary state, and then goes
through the slow relaxation to reach a final state. From analysis of simulation
data, we find (i) the time scale of the slow relaxation increases linearly to
the number of electrons if it is measured by the unit of the bulk rotation
time, (ii) during the slow relaxation process, each electron undergoes an
superdiffusive motion, and (iii) the superdiffusive motion can be regarded as
the Levy flight, whose step size distribution is of the power law. The time
scale that each electron diffuses over the system size turns out to be much
shorter than that of the slow relaxation, which suggests that the correlation
among the superdiffusive trajectories is important in the slow relaxation
process.Comment: 11pages, 19 figures. Submitted to J. Phys. Soc. Jp
Quasi-stationary States of Two-Dimensional Electron Plasma Trapped in Magnetic Field
We have performed numerical simulations on a pure electron plasma system
under a strong magnetic field, in order to examine quasi-stationary states that
the system eventually evolves into. We use ring states as the initial states,
changing the width, and find that the system evolves into a vortex crystal
state from a thinner-ring state while a state with a single-peaked density
distribution is obtained from a thicker-ring initial state. For those
quasi-stationary states, density distribution and macroscopic observables are
defined on the basis of a coarse-grained density field. We compare our results
with experiments and some statistical theories, which include the
Gibbs-Boltzmann statistics, Tsallis statistics, the fluid entropy theory, and
the minimum enstrophy state. From some of those initial states, we obtain the
quasi-stationary states which are close to the minimum enstrophy state, but we
also find that the quasi-stationary states depend upon initial states, even if
the initial states have the same energy and angular momentum, which means the
ergodicity does not hold.Comment: 9 pages, 7 figure
Quantum Locality
It is argued that while quantum mechanics contains nonlocal or entangled
states, the instantaneous or nonlocal influences sometimes thought to be
present due to violations of Bell inequalities in fact arise from mistaken
attempts to apply classical concepts and introduce probabilities in a manner
inconsistent with the Hilbert space structure of standard quantum mechanics.
Instead, Einstein locality is a valid quantum principle: objective properties
of individual quantum systems do not change when something is done to another
noninteracting system. There is no reason to suspect any conflict between
quantum theory and special relativity.Comment: Introduction has been revised, references added, minor corrections
elsewhere. To appear in Foundations of Physic
From regional pulse vaccination to global disease eradication: insights from a mathematical model of Poliomyelitis
Mass-vaccination campaigns are an important strategy in the global fight
against poliomyelitis and measles. The large-scale logistics required for these
mass immunisation campaigns magnifies the need for research into the
effectiveness and optimal deployment of pulse vaccination. In order to better
understand this control strategy, we propose a mathematical model accounting
for the disease dynamics in connected regions, incorporating seasonality,
environmental reservoirs and independent periodic pulse vaccination schedules
in each region. The effective reproduction number, , is defined and proved
to be a global threshold for persistence of the disease. Analytical and
numerical calculations show the importance of synchronising the pulse
vaccinations in connected regions and the timing of the pulses with respect to
the pathogen circulation seasonality. Our results indicate that it may be
crucial for mass-vaccination programs, such as national immunisation days, to
be synchronised across different regions. In addition, simulations show that a
migration imbalance can increase and alter how pulse vaccination should
be optimally distributed among the patches, similar to results found with
constant-rate vaccination. Furthermore, contrary to the case of constant-rate
vaccination, the fraction of environmental transmission affects the value of
when pulse vaccination is present.Comment: Added section 6.1, made other revisions, changed titl
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