Employer and labour provider perspectives on Eastern European migration to the UK

In a relatively short space of time Eastern Europe has become one of the principal source regions of migrants to the UK and citizens from these states now constitute some of the largest foreign-born populations in the country. This paper focuses on these trends from the perspective of UK employers and labour providers. Three main topics are covered; 1. The function served by East European migrant labour in the UK labour market and how this has changed over time. 2. Employers’ motivations for engaging with East European migrant labour. 3. The migration channels that shape how East European labour is sourced by UK employers. The findings demonstrate how the perspectives and practices of employers and recruiters can play an important role in influencing how East European labour migration flows to the UK are represented and produced

Spectroscopic imaging of single atoms within a bulk solid

The ability to localize, identify and measure the electronic environment of individual atoms will provide fundamental insights into many issues in materials science, physics and nanotechnology. We demonstrate, using an aberration-corrected scanning transmission microscope, the spectroscopic imaging of single La atoms inside CaTiO3. Dynamical simulations confirm that the spectroscopic information is spatially confined around the scattering atom. Furthermore we show how the depth of the atom within the crystal may be estimated.Comment: 4 pages and 3 figures. Accepted in Phys.Rev.Let

Coherent tune shift and instabilities measurements at the CERN Proton Synchrotron Booster

To understand one of the contributions to the intensity limitations of the CERN Proton Synchrotron Booster (PSB) in view of its operation with beams from Linac 4, the impedance of the machine has been characterized. Measurements of tune shift as a function of the intensity have been carried out in order to estimate the low frequency imaginary part of the impedance. Since the PSB is a low energy machine, these measurements have been done at two different energies, so as to enable us to disentangle the effect of the indirect space charge and resistive wall from the contribution of the machine impedance. An estimation of the possible resonant peaks in the impedance spectrum has been made by measuring a fast instability in Ring4

Critical role of p38 MAPK for regeneration of the sciatic nerve following crush injury in vivo

BACKGROUND The physiological function of p38α, which is an isoform of p38 MAPK, has been investigated previously in several studies using pharmacological inhibitors. However, the results regarding whether p38α promotes or inhibits nerve regeneration in vivo have been controversial. METHODS We generated novel p38α mutant mice (sem mice) with a point mutation in the region encoding the p38α substrate-docking-site, which serves as a limited loss-of-function model of p38α. In the present study, we utilized sem mice and wild-type littermates (wt mice) to investigate the physiological role of p38α in nerve regeneration following crush injuries. RESULTS At four weeks after crush injury, the average axon diameter and the average axon area in sem mice were significantly smaller than those in wt mice. The average myelin sheath thickness in sem mice was reduced compared to wt mice, but no significant difference was observed in the G-ratio between the two groups. The sciatic functional index value demonstrated that functional nerve recovery in sem mice following crush injury was delayed, which is consistent with the histological findings. To investigate the underlying mechanisms of these findings, we examined inflammatory responses of the sciatic nerve by immunohistochemistry and western blotting. At an early phase following crush injury, sem mice showed remarkably lower expression of inflammatory cytokines, such as TNF-α and IL-1β, than wt mice. The expression of Caspase-3 and Tenascin-C were also lower in sem mice. Conversely, at a late phase of the response, sem mice showed considerably higher expression of TNF-α and of IL-1β with lower expression of S-100 than wt mice. CONCLUSIONS This is the first study of the physiological role of p38 MAPK in nerve regeneration that does not rely on the use of pharmacological inhibitors. Our results indicate that p38α insufficiency may cause an inflammatory disorder, resulting in a delay of histological and functional nerve recovery following crush injury. We conclude that p38 MAPK has an important physiological role in nerve regeneration and may be important for controlling both initiation of inflammation and recovery from nerve injury.Naoki Kato, Masahito Matsumoto, Masakazu Kogawa, Gerald J Atkins, David M Findlay, Takahiko Fujikawa, Hiromi Oda and Masato Ogat

Metastable phases and "metastable" phase diagrams

The work discusses specifics of phase transitions for metastable states of substances. The objects of condensed media physics are primarily equilibrium states of substances with metastable phases viewed as an exception, while the overwhelming majority of organic substances investigated in chemistry are metastable. It turns out that at normal pressure many of simple molecular compounds based on light elements (these include: most hydrocarbons; nitrogen oxides, hydrates, and carbides; carbon oxide (CO); alcohols, glycerin etc) are metastable substances too, i.e. they do not match the Gibbs' free energy minimum for a given chemical composition. At moderate temperatures and pressures, the phase transitions for given metastable phases throughout the entire experimentally accessible time range are reversible with the equilibrium thermodynamics laws obeyed. At sufficiently high pressures (1-10 GPa), most of molecular phases irreversibly transform to more energy efficient polymerized phases, both stable and metastable. These transformations are not consistent with the equality of the Gibbs' free energies between the phases before and after the transition, i.e. they are not phase transitions in "classical" meaning. The resulting polymeric phases at normal pressure can exist at temperatures above the melting one for the initial metastable molecular phase. Striking examples of such polymers are polyethylene and a polymerized modification of CO. Many of energy-intermediate polymeric phases can apparently be synthesized by the "classical" chemistry techniques at normal pressure.Comment: 5 pages, 4 figure

High Intensity Beams from the CERN PS Booster

The CERN Proton Synchrotron Booster (PSB) has been running for more than 30 years. Originally designed to accelerate particles from 50 to 800 MeV, later upgradedto an energy of 1 GeV and finally 1.4 GeV, it is steadily being pushed to its operational limits. One challenge is the permanent demand for intensity increase, in particular for CNGS and ISOLDE, but also in view of Linac4. As it is an accelerator working with very high space charge during the low energy part of its cycle, its operational conditions have to be precisely tuned. Amongst other things resonances must be avoided, stop band crossings optimised and the machine impedance minimised. Recently, an operational intensity record was achieved with >4.25×1013 protons accelerated. An orbit correction campaign performed during the 2007/2008 shutdown was a major contributing factor to achieving this intensity. As the PSB presently has very few orbit correctors available,the orbit correction has to be achieved by displacing and/or tilting some of the defocusing quadrupoles common to all 4 PSB rings. The contributing factors used to optimise performance will be reviewed

The programming of sequences of saccades

Saccadic eye movements move the high-resolution fovea to point at regions of interest. Saccades can only be generated serially (i.e., one at a time). However, what remains unclear is the extent to which saccades are programmed in parallel (i.e., a series of such moments can be planned together) and how far ahead such planning occurs. In the current experiment, we investigate this issue with a saccade contingent preview paradigm. Participants were asked to execute saccadic eye movements in response to seven small circles presented on a screen. The extent to which participants were given prior information about target locations was varied on a trial-by-trial basis: participants were aware of the location of the next target only, the next three, five, or all seven targets. The addition of new targets to the display was made during the saccade to the next target in the sequence. The overall time taken to complete the sequence was decreased as more targets were available up to all seven targets. This was a result of a reduction in the number of saccades being executed and a reduction in their saccade latencies. Surprisingly, these results suggest that, when faced with a demand to saccade to a large number of target locations, saccade preparation about all target locations is carried out in paralle

Shine 2014 Final Report: Social Prescribing: integrating GP and Community Assets for Health

Commissioned by City and Hackney Clinical Commissioning Group, in partnership with the University of East London and Queen Mary University of London