Baseline characteristics of 12,262 enrolled subjects by sex.

<p>Baseline characteristics of 12,262 enrolled subjects by sex.</p

Interaction between alcohol intake and co-factors in the progression from chronic hepatitis to cirrhosis in male patients.

<p>Crude and Adjusted^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0185710#t003fn001" target="_blank">*</a>} Odds Ratio derived from multiple logistic regression analysis.</p

ROC curve analysis of detected markers.

a<p>Null hypothesis: true area = 0.5.</p

Markers significantly different between CP <i>vs</i> CTRL, CP-A <i>vs</i> CTRL and CP-A <i>vs</i> CP-B+C.

<p><b>Abbreviations:</b> CP, cirrhotic patients; CTRL, healthy controls; CP-A, cirrhotic Child Pugh A; CP-B+C, cirrhotic Child Pugh B+C.</p

Pearson correlation between VOCs and biochemical parameters.

<p>In bold significant correlation (<i>p</i><0.05).</p

Interaction between alcohol intake and co-factors in the progression from chronic hepatitis to cirrhosis in female patients.

<p>Crude and Adjusted Odds^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0185710#t004fn001" target="_blank">*</a>} Ratio derived from multiple logistic regression analysis.</p

Correlation and distribution of the C8-ketone.

<p>Correlation between serum bilirubin and C8-Ketone (<b>panel a</b>) and distribution of the C8-ketone breath’s concentrations in healthy controls (CTRL) and the 3 classes of cirrhotic patients (CP) (<b>panel b</b>). Variable in <b>panel a</b> are power transformation of original values (λ = 0.1152; φ = −0.9871).</p

Receiving operating characteristic (ROC) curve for Monoterpene.

<p>Diagnostic accuracy distinguishing cirrhotic patients (CP) and healthy controls (CTRL).</p

List of the 12 peaks considered in this study.

*<p>The difference between measured and expected mass is reported as part per million (ppm).</p

Expected versus observed survival in the internal validation cohort.

<p>Patients were divided into quartiles at the 25th, 50th, and 75th percentiles of the risk score. Quartile 1 coincided with ITA.LI.CA score ≤ 1, quartile 2 with score 2–3, quartile 3 with score 4–5, quartile 4 with score > 5.</p