Pathomorphological picture of diabetic nephropathy in experimental diabetes mellitus

Aim. To conduct a morphological study of the renal glomerulus in experimental diabetes mellitus and to study the pathomorphological features of the development of diabetic nephropathy. Methods. The study was carried out on 25 male Wistar rats. Modeling of diabetes mellitus was carried out by intraperitoneal injection of streptozotocin at a dose of 65 mg/kg. For more selective modeling of type 2 diabetes, the rats of the control group were intraperitoneally administered a solution of cytoflavin, calculated by the dosage of nicotinamide 115 mg/kg. In the comparison group 1 ml of physiological solution was administered in a similar manner. On day 28 of the experiment, the animals were euthanized under ether anesthesia, the kidneys were extracted, purified and washed with physiological saline. The material was fixed in a 10% neutral formalin solution. Using the morphometric method, the area of the renal glomeruli and the area of the capillary lumens were measured, and after special computer processing of digital photographs, the total area of the vascular bed in the glomerulus and the area of mesangium in the renal glomerulus were estimated. Results. After four weeks of experiment on rats with diabetes mellitus, some characteristic changes in the morphofunctional state of renal tissues developed: an increase of the area of renal glomeruli, thickening of the basement membrane of glomerular capillaries, an increase in the size of podocytes with a decrease of their number, and foci of nephrosclerosis. Conclusion. Based on the results of the study, characteristic pathomorphological phenomena in the kidneys of rats with experimental diabetes mellitus were recorded, which indicate the development of diabetic nephropathy

MODERN ARCHITECTURE BOARD INFORMATION AND CONTROL SYSTEMS OF HEAVY VEHICLES

Prospects for using the method for controlling the stress state of products made of highstrength steels based on recording signals of magnetic (MN) and magnetoacoustic (MAN) remagnetization noise are considered. The energy and emission characteristics of MN and MAN are determined by the restructuring of the magnetic texture of the ferromagnet by Brakhausen jumps, 180° and 90° domain walls, respectively, with its cyclic reversal of magnetization. Therefore, MN and MAN carry different information about the physical and mechanical properties of steels, and the parameters of their signals in interrelation can be used to construct new algorithms for monitoring and diagnosing the physical and mechanical properties of articles made of ferromagnetic materials, for example, the stressed state of the critical products from these steels. The main results on the development of the means of magneto-noise control, achieved at the department of electrical engineering and mechanics of Moscow Technological University (MGUPI), their applications in the technologies of engineering, aviation and oil and gas industries are presented