3 research outputs found
Age disparities in stageâspecific colon cancer survival across seven countries: an International Cancer Benchmarking Partnership SURVMARKâ2 populationâbased study
We sought to understand the role of stage at diagnosis in observed age disparities in colon cancer survival among people aged 50 to 99âyears using populationâbased cancer registry data from seven highâincome countries: Australia, Canada, Denmark, Ireland, New Zealand, Norway and the United Kingdom. We used colon cancer incidence data for the period 2010 to 2014. We estimated the 3âyear net survival, as well as the 3âyear net survival conditional on surviving at least 6âmonths and 1âyear after diagnosis, by country and stage at diagnosis (categorised as localised, regional or distant) using flexible parametric excess hazard regression models. In all countries, increasing age was associated with lower net survival. For example, 3âyear net survival (95% confidence interval) was 81% (80â82) for 50 to 64âyear olds and 58% (56â60) for 85 to 99âyear olds in Australia, and 74% (73â74) and 39% (39â40) in the United Kingdom, respectively. Those with distant stage colon cancer had the largest difference in colon cancer survival between the youngest and the oldest patients. Excess mortality for the oldest patients with localised or regional cancers was observed during the first 6âmonths after diagnosis. Older patients diagnosed with localised (and in some countries regional) stage colon cancer who survived 6âmonths after diagnosis experienced the same survival as their younger counterparts. Further studies examining other prognostic clinical factors such as comorbidities and treatment, and socioeconomic factors are warranted to gain further understanding of the age disparities in colon cancer survival