Unicentric or multicentric castleman disease? A case report of a pelvic intraperitoneal mass in a middle aged woman

Castleman Disease is a lymphoid disorder characterized by the presence of an enlarged or abnormal lymph node/lymphatic tissue. The disease is classified into unicentric or multicentric variants. The unicentric form is a benign disorder that is usually asymptomatic and consists of a single lymphoid mass that is predominantly located in the mediastinum, but can also rarely develop in the neck or abdomen. The multicentric type involves more than one lymphatic station and is related to the presence of type B symptoms (fevers, night sweats and weight loss), HIV/HHV8 infection and increased serum IL-6 levels. We present the case of an unusual pelvic intraperitoneal manifestation of Castleman Disease in a 52-year-old caucasian woman who showed clinical, radiological, histological and laboratory findings common to both Unicentric and Multicentric Castleman Disease

A systematic review of tests for lymph node status in primary endometrial cancer

<p>Abstract</p> <p>Background</p> <p>The lymph node status of a patient is a key determinate in staging, prognosis and adjuvant treatment of endometrial cancer. Despite this, the potential additional morbidity associated with lymphadenectomy makes its role controversial. This study systematically reviews the accuracy literature on sentinel node biopsy; ultra sound scanning, magnetic resonance imaging (MRI) and computer tomography (CT) for determining lymph node status in endometrial cancer.</p> <p>Methods</p> <p>Relevant articles were identified form MEDLINE (1966–2006), EMBASE (1980–2006), MEDION, the Cochrane library, hand searching of reference lists from primary articles and reviews, conference abstracts and contact with experts in the field. The review included 18 relevant primary studies (693 women). Data was extracted for study characteristics and quality. Bivariate random-effect model meta-analysis was used to estimate diagnostic accuracy of the various index tests.</p> <p>Results</p> <p>MRI (pooled positive LR 26.7, 95% CI 10.6 – 67.6 and negative LR 0.29 95% CI 0.17 – 0.49) and successful sentinel node biopsy (pooled positive LR 18.9 95% CI 6.7 – 53.2 and negative LR 0.22, 95% CI 0.1 – 0.48) were the most accurate tests. CT was not as accurate a test (pooled positive LR 3.8, 95% CI 2.0 – 7.3 and negative LR of 0.62, 95% CI 0.45 – 0.86. There was only one study that reported the use of ultrasound scanning.</p> <p>Conclusion</p> <p>MRI and sentinel node biopsy have shown similar diagnostic accuracy in confirming lymph node status among women with primary endometrial cancer than CT scanning, although the comparisons made are indirect and hence subject to bias. MRI should be used in preference, in light of the ASTEC trial, because of its non invasive nature.</p

Ruolo della linfadenectomia nel carcinoma dell\u2019endometrio: analisi della letteratura.

[Role of lymphadenectomy in endometrial carcinoma: analysis of the literature]

Attuali orientamenti in tema di carcinoma del collo dell’ utero in gravidanza.

Attuali orientamenti in tema di carcinoma del collo dell’ utero in gravidanza

effetti collaterali della Calcitonina di Salmone (s CT ) nella profilassi della osteoporosi postmenopausale.

effetti collaterali della Calcitonina di Salmone (s CT ) nella profilassi della osteoporosi postmenopausale

Efficacia del trattamento topico con fitostimoline sui processi cicatriziali della cupola vaginale dopo laparoisterectomia totale.

Efficacy of topical treatment with fitostimoline in healing process of vaginal vault after total laparohysterectomy(Article

La cistoscopia nella pratica ginecologica.

La cistoscopia nella pratica ginecologica

La chirurgia maggiore negli ascessi tubo-ovarici: analisi di 22 casi.

La chirurgia maggiore negli ascessi tubo-ovarici: analisi di 22 cas

Il trattamento con DTC nella condilomatosi genitale.

Il trattamento con DTC nella condilomatosi genitale