57 research outputs found
Evaluation of Diffusion Tensor Imaging Findings in Clinically Isolated Syndrome and Relapsing-Remitting Multiple Sclerosis Patients
Objective: To compare diffusion tensor imaging (DTI) findings of the normal-appearing white matter (NAWM) and corpus callosum (CC) in patients with clinically isolated syndrome (CIS) and relapsing-remitting multiple sclerosis (RRMS) and a healthy control (HC) group. Materials and Methods: The CIS (n = 10), RRMS (n = 29), and HC (n = 13) groups were evaluated by DTI in this retrospective study. Mean diffusion (MD) and fractional anisotropy (FA) maps as well as MD and FA measurements were made from the corpus callosum genu (CCG), corpus callosum splenium (CCS), and NAWM areas from the frontal, parietal, occipital and temporal lobes. Results: The mean FA values of the NAWM in the temporal lobes were bilaterally lower in both the CIS and RRMS groups than in the HC group. However, no difference was found between the CIS and RRMS groups. In addition, the CIS group had lower FA values in the CCG, whereas the RRMS group had lower FA values in the CCS compared with the HC group. The MD values were significantly different in the CCG between the RRMS and HC groups. Conclusion: DTI contributes to detecting early changes in the NAWM and CC in patients diagnosed with CIS and RRMS. Additionally, DTI can aid in the follow-up care and management of these patients
A comparative ID migraine screener study in ophthalmology, ENT and neurology out-patient clinics
Migraine is more likely to be misdiagnosed in patients with comorbid diseases. Not only primary care physicians, but also specialists might misdiagnose it due to the lack of diagnostic criteria awareness. The ID migraine test is a reliable screening instrument that may facilitate and accelerate migraine recognition. This study aimed to compare the prevalence and characteristics of migraine in a large sample of patients admitted to clinics of ophthalmology (OC), ear, nose and throat diseases (ENTC) and neurology (NC), as well as to validate the use of the ID migraine test in OC and ENTC settings. This was a multicentre (11 cites) study of out-patients admitting either to NC, ENTC or OC of the study sites during five consecutive working days within 1 week. From each of the clinics, 100 patients were planned to be recruited. All recruited patients were interviewed and those having a headache complaint received an ID migraine test and were examined for headache diagnosis by a neurologist, blinded to the ID migraine test result. A total of 2625 subjects were recruited. Only 1.3% of OC patients and 5.4% of ENTC patients have been admitted with a primary complaint of headache, whereas the percentage of NC patients suffering from headache was 37.6%. Whereas 138 patients (19.3%) in OC, 154 (17.3%) in ENTC and 347 (34%) in NC were found to be ID migraine test positive, 149 patients (20.8%) in OC, 142 (16%) in ENTC and 338 (33.1%) in NC were diagnosed with migraine. The sensitivity, specificity, and positive and negative predictive ratios of the ID migraine test were found to be similar in all clinics. An important fraction of the patients admitted to NC, as well as to OC and ENTC, for headache and/or other complaints were found out to have migraine by means of a simple screening test. This study validated the ID migraine test as a sensitive and specific tool in OC and ENTC, encouraging its use as a screening instrument.Pfizer-Türkiy
Akut ve kronik optik nevritli hastalarda görsel sistemin difüzyon tensor görüntülemetekniği ile incelenmesi ve diğer inceleme yöntemleriyle uygunluğunun değerlendirilmesi
Antikonvülzan kullanan primer jeneralize ve parsiyel epilepsili olgularda olayla ilişkili serebral potansiyellerle (P300-CNV) yapılan multiparametrik değerlendirmeler
Auralı ve aurasız migrenlilerde görsel stimülasyonla tetiklenmiş başağrısı atağı öncesi ve sırasında internal juguler venöz kanda bazı nöral mediatörlerin ve beyin sapında manyetik rezonans spektroskopik değişikliklerin incelenmesi
Multipl Skleroz'lu hastalarda nitrik oksid metabolitleri ölçümünün, hastalık aktivite belirticisi olması açısından duyarlılık ve özgüllüğünün değerlendirilmesi ve nörofizyolojik ve nöroradyolojik verilerle korelasyonu
Multipl Skleroz'da optik sinir etkilenmesi klinik özellikler, görsel uyarılmış potansiyeller, orbita ve kranyal manyetik rezonans görüntüleme ve HLA grupları
Primer vasküler baş ağrısı olgularında görsel olarak tetiklenmiş baş ağrısı oluşturarak perfüzyon MRG ve MR spektroskopi ile serebral değişiklikleri değerlendirmek
Unilateral vestibüler yetmezlikte modifiye cawthorne-cooksey egzersizleri ile genel vestibüler rehabilitasyonun etkinliği
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