From soft sediment deformation to fluid assisted faulting in the shallow part of a subduction megathrust analogue: the Sestola Vidiciatico tectonic Unit (Northern Apennines, Italy)

The Sestola Vidiciatico tectonic Unit (SVU) accommodated the early Miocene convergence between the subducting Adriatic plate and the overriding Ligurian prism, and has been interpreted as a field analogue for the shallow portion of subduction megathrusts. The SVU incorporated sediments shortly after their deposition and was active down to burial depth corresponding to temperatures around 150 \ub0C. Here, we describe the internal architecture of the basal thrust fault of the SVU through a multi-scale structural analysis and investigate the evolution of the deformation mechanisms with increasing burial depth. At shallow depth, the thrust developed in poorly lithified sediments which deformed by particulate flow. With increasing depth and lithification of sediments, deformation was accommodated in a meter scale, heterogeneous fault zone, including multiple strands of crack-and-seal shear veins, associated with minor distributed shearing in clay-rich domains and pressure solution. In the last stage, slip localized along a sharp, 20 cm thick shear vein, deactivating the fault zone towards the footwall. The widespread formation of crack-and-seal shear veins since the first stages of lithification indicates that failure along the thrust occurred at high fluid pressure and low differential stress already at shallow depth. Progressive shear localization occurs in the last phases of deformation, at temperatures typical of the transition to the seismogenic zone in active megathrusts

Faunal exploitation during the Proto-Zhou period in the Jing River Valley: Evidence from Sunjia and Xitou

This study examines faunal assemblages from the Proto-Zhou sites of Sunjia and Xitou, in the Jing River Valley (Central Shaanxi Province), to address questions concerning the exploitation of different animal resources in the context of the Shang-Zhou dynastic transition in the 11th century BCE. Although the assemblages from Sunjia and Xitou were small and sub-optimally preserved, this study demonstrates that the inclusion of such assemblages is essential to building upon our understanding of the human exploitation of animal resources. Our zooarchaeological analysis shows an increase in husbandry, with pig farming being complemented by extensive caprine and cattle herding. A diversified use of animal resources, and especially the larger number of bovids, could have been prompted by the need for a wider and more efficient exploitation of the immediate environment, in response to growing climatic deterioration, in addition to an increase in interactions with northern pastoral communities. Identified patterns of livestock biometry and relative taxonomic abundance show various degrees of agricultural engagement and a relatively complex livestock economy, suggesting the development of socio-economic complexity in the Jing River Valley in the late second millennium BCE

Gestational Diabetes Mellitus pregnancy by pregnancy. early, late and nonrecurrent GDM

Aims: To assess the GDM recurrence rate in a cohort of pregnant women with prior GDM, to compare two consecutive pregnancies complicated by GDM, to compare women with nonrecurrent and recurrent GDM and to stratify the latter in women with early and late recurrent GDM.Methods: Retrospective study including 113 women with GDM in an index pregnancy (G1), at least a postindex pregnancy (G2) and normal glucose tolerance in between. The GDM recurrence rate was assessed, and maternal and neonatal outcomes and pancreatic beta cell function of the index pregnancy were compared with those of the postindex pregnancy (G1 vs. G2). Women with nonrecurrent GDM were compared with those with recurrent GDM.Results: The GDM recurrence rate was 83.2% and the minimum prevalence of early recurrent GDM was 43,4%. The pregravid BMI of women with recurrent GDM increased between the two pregnancies (27.3 +/- 5.98 vs. 28.1 +/- 6.19 kg/m(2), p < 0.05). Women with recurrent GDM had a higher prepregnancy BMI than those with nonrecurrent GDM either at the index (27.3 +/- 5.98 vs. 23.1 +/- 4.78 kg/m(2), p < 0.05) or the postindex pregnancy (27 +/- 6vs.24 +/- 4,4 kg/m2, p < 0.05).Conclusions: GDM shows a high recurrence rate in our cohort of slightly overweight women, with an early GDM minimum prevalence of 43.4%

Applying genomic approaches to identify historic population declines in European forest bats

1. Anthropogenically driven environmental changes over recent centuries have led to severe declines of wildlife populations. Better tools are needed to assess the magnitude and consequences of these declines. Anecdotal evidence suggests European bat populations have suffered substantial declines in the past centuries. However, there is little empirical evidence of these declines that can be used to put more recent population trends into historic context.2. This study is a collaboration between academics and conservation practitioners to develop molecular approaches capable of providing evidence of historic population changes that can inform conservation status assessments and management. We generated a genomic dataset of 46,872 SNPs for the Western barbastelle, Barbastella barbastellus, a regionally Vulnerable bat species, including colonies from across the species' British and Iberian ranges. We used a combination of landscape genetics and model-based inference of demographic history to identify both evidence of population size changes and possible drivers of these changes.3. Levels of genetic diversity increased and inbreeding decreased with increasing broadleaf woodland cover around the colony. Genetic connectivity was impeded by artificial lights and facilitated by rivers and broadleaf woodland cover.4. The demographic history analysis showed that both the northern and southern British barbastelle populations have declined by 99% over the past 330–548 years. These declines may be linked to the loss of large oak trees and native woodlands due to shipbuilding during the early colonial period.5. Synthesis and applications. Genomic approaches can provide a better understanding of the conservation status of threatened species, within historic and contemporary contexts, and inform their conservation management. Our findings of will directly influence the definition of the Favourable Conservation Status of the barbastelle, in turn influencing considerations of the conservation of the species in development plans. Knowledge gained will also help set species recovery targets. Policymakers are interested in using our approach for other species. This study shows how we can bridge the implementation gap between genomic research and direct conservation applications. There is an urgent need to carry out such collaborative studies for other priority species to enable informed species recovery interventions via policy mechanisms and project delivery

A New Web Score to Predict Health Status in Paediatric Patients with Chronic Diseases: Design and Development of the PENSAMI Study

Paediatric chronic diseases (CD) are characterised by their ongoing duration and the fact that they are often managed throughout the lifespan, with the need to adjust lifestyle and expectations with the limitations coming from the CD. The aim of the PENSAMI study is to not only cure the disease, but to also care for the person from a clinical and psychosocial perspective. Data will be collected from 150 paediatric patients affected by heart disease, diabetes, and asthma admitted during in-hospital stay or outpatient visits, and from 200 healthy control subjects. The protocol will consist of two phases. The first one will aim at elaborating the predictive model by detecting (clinical, anthropometric at birth, environmental, lifestyle, social context, emotional state, and mental abilities) in order to develop a model predictive of the events considered: (1) re-hospitalisation; (2) severity and progression of the disease; (3) adherence to therapy; (4) HRQoL; (5) obesity and metabolic syndrome; (6) illness-stress related; (7) school drop-out; (8) school performance. The second one will address validating the previous predictive model. This model will aim to: (1) understand, prevent, and halt the progression of childhood CD; (2) develop new and improved diagnostic tools; (3) pave the way for innovative treatments and additional therapies to traditional clinical practice; and (4) create truly personalised therapeutic and preventive strategies in various sectors, such as cardiology, diabetes, and respiratory diseases

Transnational Access to Research Facilities: an EPOS service to promote multi-domain Solid Earth Sciences in Europe

Transnational access (TNA) allows cross-border, short-term and frequently free-of-charge access to world-class research facilities, to foster collaborations and exchanges of experience. Specifically, TNA aims to encourage open science and innovation and to increase the efficient and effective use of scientific infrastructure. Within EPOS, the European Plate Observing System, the Volcano Observatories and Multi-scale Laboratories communities have offered TNA to their high-quality research facilities through national and European funding. This experience has allowed the definition, design, and testing of procedures and activities needed to provide transnational access inn the EPOS context. In this paper, the EPOS community describes the main objectives for the provision of transnational access in the EPOS framework, based on previous experiences. It includes practical procedures for managing transnational access from a legal, governance, and financial perspective, and proposes logistical and technical solutions to effectively execute transnational access activities. In addition, it provides an outlook on the inclusion of new thematic communities within the TNA framework, and addresses the challenges of providing market-driven access to industry.publishedVersio

Multisystem involvement, defective lysosomes, and impaired autophagy in a novel rat model of Nephropathic Cystinosis

Recessive mutations in the CTNS gene encoding the lysosomal transporter cystinosin cause cystinosis, a lysosomal storage disease leading to kidney failure and multisystem manifestations. A Ctns knock-out mouse model recapitulates features of cystinosis, but the delayed onset of kidney manifestations, phenotype variability, and strain effects limit its use for mechanistic and drug development studies. To provide a better model for cystinosis, we generated a Ctns knock-out rat model using CRISPR/Cas9 technology. The Ctns-/- rats display progressive cystine accumulation and crystal formation in multiple tissues including kidney, liver and thyroid. They show an early onset and progressive loss of urinary solutes, indicating generalized proximal tubule dysfunction, with development of typical swan-neck lesions, tubulointerstitial fibrosis and kidney failure, and decreased survival. The Ctns-/- rats also present crystals in the cornea, and bone and liver defects, like in patients. Mechanistically, the loss of cystinosin induces a phenotype switch associating abnormal proliferation and dedifferentiation, loss of apical receptors and transporters, and defective lysosomal activity and autophagy in the cells. Primary cultures of proximal tubule cells derived from the Ctns-/- rat kidneys confirmed the key changes caused by cystine overload, including reduced endocytic uptake, increased proliferation and defective lysosomal dynamics and autophagy. The novel Ctns-/- rat model and derived proximal tubule cell system provide invaluable tools to investigate the pathogenesis of cystinosis and to accelerate drug discovery