Rotating perfect fluid sources of the NUT metric

Locally rotationally symmetric perfect fluid solutions of Einstein's gravitational equations are matched along the hypersurface of vanishing pressure with the NUT metric. These rigidly rotating fluids are interpreted as sources for the vacuum exterior which consists only of a stationary region of the Taub-NUT space-time. The solution of the matching conditions leaves generally three parameters in the global solution. Examples of perfect fluid sources are discussed.Comment: 8 pages, late

Ellipsoidal shapes in general relativity: general definitions and an application

A generalization of the notion of ellipsoids to curved Riemannian spaces is given and the possibility to use it in describing the shapes of rotating bodies in general relativity is examined. As an illustrative example, stationary, axisymmetric perfect-fluid spacetimes with a so-called confocal inside ellipsoidal symmetry are investigated in detail under the assumption that the 4-velocity of the fluid is parallel to a time-like Killing vector field. A class of perfect-fluid metrics representing interior NUT-spacetimes is obtained along with a vacuum solution with a non-zero cosmological constant.Comment: Latex, 22 pages, Revised version accepted in Class. Quantum. Grav., references adde

The German mouse clinic: A platform for systemic phenotype analysis of mouse models

The German Mouse Clinic (GMC) is a large scale phenotyping center where mouse mutant lines are analyzed in a standardized and comprehensive way. The result is an almost complete picture of the phenotype of a mouse mutant line - a systemic view. At the GMC, expert scientists from various fields of mouse research work in close cooperation with clinicians side by side at one location. The phenotype screens comprise the following areas: allergy, behavior, clinical chemistry, cardiovascular analyses, dysmorphology, bone and cartilage, energy metabolism, eye and vision, hostpathogen interactions, immunology, lung function, molecular phenotyping, neurology, nociception, steroid metabolism, and pathology. The German Mouse Clinic is an open access platform that offers a collaboration-based phenotyping to the scientific community (www.mouseclinic.de). More than 80 mutant lines have been analyzed in a primary screen for 320 parameters, and for 95% of the mutant lines we have found new or additional phenotypes that were not associated with the mouse line before. Our data contributed to the association of mutant mouse lines to the corresponding human disease. In addition, the systemic phenotype analysis accounts for pleiotropic gene functions and refines previous phenotypic characterizations. This is an important basis for the analysis of underlying disease mechanisms. We are currently setting up a platform that will include environmental challenge tests to decipher genome-environmental interactions in the areas nutrition, exercise, air, stress and infection with different standardized experiments. This will help us to identify genetic predispositions as susceptibility factors for environmental influences