22 research outputs found

    High prevalence of GB virus C in Brazil and molecular evidence for intrafamilial transmission

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    The prevalence of GB virus C (GBV-C) in candidate Brazilian blood donors with normal and elevated alanine aminotransferase levels was found to be 5.2% (5 of 95) and 6.5% (5 of 76), respectively. Among Brazilian patients, GBV-C was Found in 9.5% (13 of 137) of cases of hepatitis not caused by hepatitis A,virus (HAV), HBV, HCV, HDV, or HEV (non-A-E hepatitis) and in 18.2% (8 of 44) of individuals infected with HCV. Molecular characterization of GBV-C by partial sequencing of the NS3 region showed clustering between members of a single family, implying intrafamilial transmission. In conclusion, these results together suggest that contagion mechanisms which facilitate intrafamiliar transmission of GBV-C may partially explain the high prevalence of viremic carriers worldwide.3751634163
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