Streptozotocin-induced mechanical hypernociception is not dependent on hyperglycemia

Since streptozotocin (STZ)-induced diabetes is a widely used model of painful diabetic neuropathy, the aim of the present study was to design a rational protocol to investigate whether the development of mechanical hypernociception induced by STZ depends exclusively on hyperglycemia. Male Wistar rats (180-200 g; N = 6-7 per group) received a single intravenous injection of STZ at three different doses (10, 20, or 40 mg/kg). Only the higher dose (40 mg/kg) induced a significant increase in blood glucose levels, glucose tolerance and deficiency in weight gain. However, all STZ-treated rats (hyperglycemic or not) developed persistent (for at least 20 days) and indistinguishable bilateral mechanical hypernociception that was not prevented by daily insulin treatment (2 IU twice a day, sc). Systemic morphine (2 mg/kg) but not local (intraplantar) morphine treatment (8 µg/paw) significantly inhibited the mechanical hypernociception induced by STZ (10 or 40 mg/kg). In addition, intraplantar injection of STZ at doses that did not cause hyperglycemia (30, 100 or 300 µg/paw) induced ipsilateral mechanical hypernociception for at least 8 h that was inhibited by local and systemic morphine treatment (8 µg/paw or 2 mg/kg, respectively), but not by dexamethasone (1 mg/kg, sc). The results of this study demonstrate that systemic administration of STZ induces mechanical hypernociception that does not depend on hyperglycemia and intraplantar STZ induces mechanical sensitization of primary sensory neurons responsive to local morphine treatment.FAPESPCNPqPrograma de Núcleos de Excelência (PRONEX

An interleukin-33/ST2 signaling deficiency reduces overt pain-like behaviors in mice

Interleukin (IL)-33, the most recent member of the IL family of cytokines, signals through the ST2 receptor. IL-33/ST2 signaling mediates antigen challenge-induced mechanical hyperalgesia in the joints and cutaneous tissues of immunized mice. The present study asked whether IL-33/ST2 signaling is relevant to overt pain-like behaviors in mice. Acetic acid and phenyl-p-benzoquinone induced significant writhing responses in wild-type (WT) mice; this overt nociceptive behavior was reduced in ST2-deficient mice. In an antigen-challenge model, ST2-deficient immunized mice had reduced induced flinch and licking overt pain-like behaviors. In the formalin test, ST2-deficient mice also presented reduced flinch and licking responses, compared with WT mice. Naive WT and ST2-deficient mice presented similar responses in the rota-rod, hot plate, and electronic von Frey tests, indicating no impairment of motor function or alteration in basal nociceptive responses. The results demonstrate that IL-33/ST2 signaling is important in the development of overt pain-like behaviors

Accelerated expansion of the universe driven by tachyonic matter

It is an accepted practice in cosmology to invoke a scalar field with potential $V(\phi)$ when observed evolution of the universe cannot be reconciled with theoretical prejudices. Since one function-degree-of-freedom in the expansion factor $a(t)$ can be traded off for the function $V(\phi)$, it is {\it always} possible to find a scalar field potential which will reproduce a given evolution. I provide a recipe for determining $V(\phi)$ from $a(t)$ in two cases:(i) Normal scalar field with Lagrangian ${\cal L} = (1/2)\partial_a\phi \partial^a\phi - V(\phi)$ used in quintessence/dark energy models. (ii) A tachyonic field with Lagrangian ${\cal L} = -V(\phi) [ 1- \partial_a\phi \partial^a\phi]^{1/2}$, motivated by recent string theoretic results. In the latter case, it is possible to have accelerated expansion of the universe during the late phase in certain cases. This suggests a string theory based interpretation of the current phase of the universe with tachyonic condensate acting as effective cosmological constant.Comment: 4 pages; uses revtex

Uso da adubação orgânica e cobertura morta na cultura da calêndula (Calendula officinalis L.).

A calêndula representa fonte alternativa econômica principalmente para a agricultura familiar. O objetivo do presente trabalho foi avaliar os efeitos da adubação orgânica e do uso da cobertura morta sobre a produção de biomassa e teor de flavonóides totais em plantas de calêndula. O experimento foi realizado no Campus de Montes Claros da Universidade Federal de Minas Gerais, utilizando-se o delineamento em blocos casualizados em esquema fatorial 2x2x4 com quatro repetições: duas épocas de colheita, presença ou ausência de cobertura morta e quatro doses de composto orgânico (0, 30, 60 e 90 t ha-1). As maiores produções de biomassa e flavonóides totais foram verificadas com o aumento das doses de composto orgânico. Para os flavonóides totais o maior teor foi obtido na segunda colheita na presença de cobertura morta

Can the clustered dark matter and the smooth dark energy arise from the same scalar field ?

Cosmological observations suggest the existence of two different kinds of energy densities dominating at small ($\lesssim 500$ Mpc) and large ($\gtrsim 1000$ Mpc) scales. The dark matter component, which dominates at small scales, contributes $\Omega_m \approx 0.35$ and has an equation of state $p=0$ while the dark energy component, which dominates at large scales, contributes $\Omega_V \approx 0.65$ and has an equation of state $p\simeq -\rho$. It is usual to postulate wimps for the first component and some form of scalar field or cosmological constant for the second component. We explore the possibility of a scalar field with a Lagrangian L =- V(\phi) \sqrt{1 - \del^i \phi \del_i \phi} acting as {\it both} clustered dark matter and smoother dark energy and having a scale dependent equation of state. This model predicts a relation between the ratio $r = \rho_V/\rho_{\rm DM}$ of the energy densities of the two dark components and expansion rate $n$ of the universe (with $a(t) \propto t^n$) in the form $n = (2/3) (1+r)$. For $r \approx 2$, we get $n \approx 2$ which is consistent with observations.Comment: Revised to match the published version. Minor changes and a reference adde

Challenges and Obstacles for a Bouncing Universe in Brane Models

A Brane evolving in the background of a charged AdS black-hole displays in general a bouncing behaviour with a smooth transition from a contracting to an expanding phase. We examine in detail the conditions and consequences of this behaviour in various cases. For a cosmological-constant-dominated Brane, we obtain a singularity-free, inflationary era which is shown to be compatible only with an intermediate-scale fundamental Planck mass. For a radiation-dominated Brane, the bouncing behaviour can occur only for background-charge values exceeding those allowed for non-extremal black holes. For a matter-dominated Brane, the black-hole mass affects the proper volume or the expansion rate of the Brane. We also consider the Brane evolving in an asymmetric background of two distinct charged AdS black hole spacetimes being bounded by the Brane and find that, in the case of an empty critical Brane, bouncing behaviour occurs only if the black-hole mass difference is smaller than a certain value. The effects of a Brane curvature term on the bounce at early and late times are also investigated.Comment: 23 pages, Latex file, comments and references added, version to appear in Phys. Rev.

Interatomic potentials for atomistic simulations of the Ti-Al system

Semi-empirical interatomic potentials have been developed for Al, alpha-Ti, and gamma-TiAl within the embedded atomic method (EAM) by fitting to a large database of experimental as well as ab-initio data. The ab-initio calculations were performed by the linear augmented plane wave (LAPW) method within the density functional theory to obtain the equations of state for a number of crystal structures of the Ti-Al system. Some of the calculated LAPW energies were used for fitting the potentials while others for examining their quality. The potentials correctly predict the equilibrium crystal structures of the phases and accurately reproduce their basic lattice properties. The potentials are applied to calculate the energies of point defects, surfaces, planar faults in the equilibrium structures. Unlike earlier EAM potentials for the Ti-Al system, the proposed potentials provide reasonable description of the lattice thermal expansion, demonstrating their usefulness in the molecular dynamics or Monte Carlo studies at high temperatures. The energy along the tetragonal deformation path (Bain transformation) in gamma-TiAl calculated with the EAM potential is in a fairly good agreement with LAPW calculations. Equilibrium point defect concentrations in gamma-TiAl are studied using the EAM potential. It is found that antisite defects strongly dominate over vacancies at all compositions around stoichiometry, indicating that gamm-TiAl is an antisite disorder compound in agreement with experimental data.Comment: 46 pages, 6 figures (Physical Review B, in press

Born-Infeld Type Phantom Model in the ω−ω′\omega-\omega' Plane

In this paper, we investigate the dynamics of Born-Infeld(B-I) phantom model in the $\omega-\omega'$ plane, which is defined by the equation of state parameter for the dark energy and its derivative with respect to $N$(the logarithm of the scale factor $a$). We find the scalar field equation of motion in $\omega-\omega'$ plane, and show mathematically the property of attractor solutions which correspond to $\omega_\phi\sim-1$, $\Omega_\phi=1$, which avoid the "Big rip" problem and meets the current observations well.Comment: 6 pages, 3 figures, some references adde