Topology Optimization and Failure Analysis of Deployable Thin Shells with Cutouts

Shell structures with cutouts are widely used in architectural and engineering applications. For thin, lightweight, and deployable space structures, cutouts are cleverly positioned to fold and store the structure in a small volume. To maintain shape accuracy, these structures must fold without becoming damaged and must be stiff in their deployed configurations. Intuitive designs often fail to satisfy these two requirements. This research proposes solutions to the topology optimization of composite, thin shell structures with cutouts. A novel optimization algorithm was developed that makes no assumptions on the initial number, shape, and location of cutouts on deployable thin shells. The algorithm uses a density-based approach, which distributes the material within the structure by assigning a density parameter to discretized locations. This parametrization of the design domain allows for the finding of new features and the connectivity of the domain, thus providing a completely general formulation to the optimization problem. The goal is to study the effects of volume and stress constraints imposed in a deformed configuration of thin shell structures. While classical topology optimization studies focus on finding solutions to linear problems, this method is applicable to geometrically nonlinear problems and implements stress constraints in the deformed, and hence most stressed, configuration of these shells. A mathematical formulation of the optimization problem and interpolation schemes for stiffness tensor, volume, and stress are presented. A sensitivity analysis of objective function, volume, and stress constraints is provided. Finally, solutions for a thin plate and a tape spring are proposed. Density-based methods are computationally expensive when applied to large structures and complex shapes because of the large number of design variables. To address these challenges, two optimization methods that provide more specific solutions to the problem of composite, deployable shells are proposed. The first method uses level sets to parametrize the cutouts, thereby restricting the design space and simultaneously limiting the number of design variables. This greatly reduces the computational cost. Using this approach, successful solutions are found for stiff, composite, thin shells with complex shapes that can fold without becoming damaged. The second method uses a spline representation of the contour of a single cutout on the shell, thus performing fine tuning of the shape of the cutout. Modeling techniques that simulate localized strain and experimental methods for studying the quasi-static folding of these composite shells are developed. A laminate failure criterion suitable for thin, plain-weave composites is used in simulations to predict the onset of failure in folded shells. Numerical results are validated with folding experiments that demonstrated good agreement with numerical solutions. Lastly, it was discovered that many of the best performing solutions have multiple closely spaced cutouts, as opposed to current designs for deployable space structures that have fewer large cutouts. This leads to the formation of small strips of material between cutouts. Hence, the behavior of thin, plain-weave composite material was characterized and the first study on size-scaling effects at small length scales (≤ 15 mm) in this type of material was performed. Size-scaling effects on stiffness and strength shown in this study were introduced in numerical simulations of deployable thin shells. The study demonstrates that the prediction of the onset of failure in folded shells strongly depends on these size effects. Numerical predictions are corroborated by an experimental investigation of localized damage in thin strips of material forming between cutouts. Deployable shells resulting from the optimization studies are built and tested and localized damage is measured via digital volume correlation techniques.</p

Bilocal Dynamics for Self-Avoiding Walks

We introduce several bilocal algorithms for lattice self-avoiding walks that provide reasonable models for the physical kinetics of polymers in the absence of hydrodynamic effects. We discuss their ergodicity in different confined geometries, for instance in strips and in slabs. A short discussion of the dynamical properties in the absence of interactions is given.Comment: 38 LaTeX2e pages with 9 postscript figure

The Intention to Purchase Recycled Products: Towards an Integrative Theoretical Framework

The growing interest of the scientific literature regarding purchase behavior, circular economy and new business models has generated the need, as well as the opportunity, for a comprehensive review and categorization of the state of the existing research carried out so far. The present study aims at reconciling the wide but fragmented literature dealing with the purchase intention of recycled products. An integrative theoretical framework, able to combine several constructs, perspectives, and theories discussed to date on the topic, is proposed. Such framework represents a further step toward a comprehensive understanding of behavioral theories and constructs, which need to be understood to design effective business models for the circular economy. This effort could be highly valuable both for scholars interested in the topic—as the integrative framework could assist them in theorizing additional effects—and for firms’ managers—who can understand, more in depth, the drivers of the consumers’ purchasing process and act accordingly

A case of dyspnea: respiratory failure due to pulmonary arteriovenous malformation

Pulmonary arteriovenous malformations (PAVMs) are abnormal communications between pulmonary arteries and veins. The clinical features suggestive of PAVMs are stigmata of right-to-left shunting (dyspnea, hypoxemia, cyanosis, cerebral embolism, brain abscess), unexplained hemoptysis, or hemothorax. We present a case of a young man who presented to the Emergency Department complaining of dyspnea, polycythemia, and persistent hypoxemia. Angio-computed tomographic scan of the chest detected multiple PAVMs. PAVMs are uncommon in the general population, but they represent an important consideration in the differential diagnosis of common pulmonary problems, including hypoxemia, pulmonary nodules, and hemoptysis

Formoterol Exerts Anti-Cancer Effects Modulating Oxidative Stress and Epithelial-Mesenchymal Transition Processes in Cigarette Smoke Extract Exposed Lung Adenocarcinoma Cells

Lung cancer frequently affects patients with Chronic Obstructive Pulmonary Disease (COPD). Cigarette smoke (CS) fosters cancer progression by increasing oxidative stress and by modulating epithelial-mesenchymal transition (EMT) processes in cancer cells. Formoterol (FO), a long-acting β2-agonist widely used for the treatment of COPD, exerts antioxidant activities. This study explored in a lung adenocarcinoma cell line (A549) whether FO counteracted the effects of cigarette smoke extract (CSE) relative to oxidative stress, inflammation, EMT processes, and cell migration and proliferation. A549 was stimulated with CSE and FO, ROS were evaluated by flow-cytometry and by nanostructured electrochemical sensor, EMT markers were evaluated by flow-cytometry and Real-Time PCR, IL-8 was evaluated by ELISA, cell migration was assessed by scratch and phalloidin test, and cell proliferation was assessed by clonogenic assay. CSE significantly increased the production of ROS, IL-8 release, cell migration and proliferation, and SNAIL1 expression but significantly decreased E-cadherin expression. FO reverted all these phenomena in CSE-stimulated A549 cells. The present study provides intriguing evidence that FO may exert anti-cancer effects by reverting oxidative stress, inflammation, and EMT markers induced by CS. These findings must be validated in future clinical studies to support FO as a valuable add-on treatment for lung cancer management

Electrochemical sensor for evaluating oxidative stress in airway epithelial cells

Cigarette smoke exposure induces oxidative stress within the airways. Increased oxidative burden contributes to the pathogenesis of chronic lung disorders and is associated with aging and chronic inflammation. Airway epithelial cells highly contribute to Reactive Oxygen Species (ROS) generation within injured and inflamed lung tissues. Among ROS, hydrogen peroxide (H2O2) can be monitored in the extracellular space. Herein, we present an amperometric/voltammetric sensor based on gold nanoparticles and graphene oxide able to detect H2O2 with good sensitivity and selectivity. Using this sensor, H2O2 release was measured in conditioned medium from primary bronchial epithelial cells (PBEC), bronchial epithelial cell line, 16HBE, and adenocarcinoma alveolar basal epithelial cell line, A549, exposed to cigarette smoke extracts (CSE). 16HBE were also treated with resveratrol, an anti-oxidant compound. The results were compared with those obtained by flow cytometry using the same cells stained with Carboxy-H2DCFDA and MitoSOX Red, which detect intracellular ROS and mitochondrial superoxide, respectively. The exposure to CSE resulted in a significant increase of the cathodic current due to the reduction of H2O2 indicating an increased release. Addition of resveratrol decreased CSE-induced release of H2O2 in 16HBE. All the results paralleled those obtained by flow cytometry. The proposed sensor is highly sensitive and selective, fast and cost effective and can potentially be applied for real time and easy monitoring of oxidative stress

Multiple in vitro and in vivo regulatory effects of budesonide in CD4+ T lymphocyte subpopulations of allergic asthmatics.

Abstract BACKGROUND: Increased activation and increased survival of T lymphocytes characterise bronchial asthma. OBJECTIVES: In this study the effect of budesonide on T cell survival, on inducible co-stimulator T cells (ICOS), on Foxp3 and on IL-10 molecules in T lymphocyte sub-populations was assessed. METHODS: Cell survival (by annexin V binding) and ICOS in total lymphocytes, in CD4+/CD25+ and in CD4+/CD25- and Foxp3 and IL-10 in CD4+/CD25+ and in CD4+/CD25-cells was evaluated, by cytofluorimetric analysis, in mild intermittent asthmatics (n = 19) and in controls (n = 15). Allergen induced T lymphocyte proliferation and the in vivo effects of budesonide in mild persistent asthmatics (n = 6) were also explored. RESULTS: Foxp3 was reduced in CD4+/CD25- and in CD4+/CD25+ cells and ICOS was reduced in CD4+/CD25+ cells but it was increased in CD4+CD25-in asthmatics when compared to controls. In asthmatics, in vitro, budesonide was able to: 1) increase annexin V binding and to reduce ICOS in total lymphocytes; 2) increase annexin V binding and Foxp3 and to reduce ICOS in CD4+/CD25- cells; 3) reduce annexin V binding and to increase IL-10 and ICOS in CD4+/CD25+ cells; 4) reduce cell allergen induced proliferation. In vivo, budesonide increased ICOS in CD4+/CD25+ while it increased Foxp3 and IL-10 in CD4+/CD25+ and in CD4+/CD25- cells. CONCLUSIONS: Budesonide modulates T cell survival, ICOS, Foxp3 and IL-10 molecules differently in T lymphocyte sub-populations. The findings provided shed light on new mechanisms by which corticosteroids, drugs widely used for the clinical management of bronchial asthma, control T lymphocyte activation