Proposal for applying combined selection to diallel analysis.

The phylosophy of intrapopulation combined selection is the search for and identification of individuals with superior genotypic behavior, based on their performance compared to the family mean and, at the same time, of their family mean in relation to the population mean, through the weighting of the phenotypic values represented, respectively, by the within and among families heritability coeficient. The objective of this study was to adapt and apply this philosophy ti diallel analysis. The crosses were considered as having fixed effects and selected on the basis of their specific combining ability (SCA), and on the mean performance of the two involved parents, in relation to the general combining ability (GCA). This work was based on Griffing's (Heredity 10; 35-50, 1956) method 2, model 1 which involves p(p+1)/2 treatments. The proposed index result from the weighting of the effects of GCA (gi's) and SCA (sij's) by the respective determination coefficient of additive and dominant genetic determinations, resulting from the partitioning of the total genotypic determination coefficient. An example is given for illustration

Cultivares de milho para o Estado do Espírito Santo.

Vinte e cinco cultivares de milho, de ciclo normal, e vinte e cinco de ciclo precoce foram avaliados de 1990 a 1992, em 10 ambientes do Estado do Espirito Santo, sendo seis com irrigacao e quatro sem irrigacao. O delineameto experimental foi o latico 5x5 com tres repeticoes para cada tipo de ensaio. Com base nos resultados recomendam-se os seguintes cultivares: Grupo Normal - AG612, G 700, AG 6601, P 3210, G 551, G 650, CONT 533, XL 604, C 135, P 3226; Grupo precoce - G 600, AG 122, C 505, C 431, C 805, BR 201, AG 513, G 85, AG 405, G 96, C e AG 519.Em media os cultivares do grupo normal e recoce avaliados com irrigacao forma 34,6% e 50,1%, repectivamente, mais produtivos que em condicoes sem irrigacao. As produtividades medias de graos forma de 5.559 kg/ha e 5.915 kg/ha para os grupos normal e precoce, respectivamente, tendo alcancado ate 6.707 e 7.202 kg/ha em analise conjunta nos 10 ambientes

Recommendations for the treatment of epilepsy in adult and pediatric patients in Belgium : 2020 update

To guide health care professionals in Belgium in selecting the appropriate antiepileptic drugs (AEDs) for their epilepsy patients, a group of Belgian epilepsy experts developed recommendations for AED treatment in adults and children (initial recommendations in 2008, updated in 2012). As new drugs have become available, others have been withdrawn, new indications have been approved and recommendations for pregnant women have changed, a new update was pertinent. A group of Belgian epilepsy experts (partly overlapping with the group in charge of the 2008/2012 recommendations) evaluated the most recent international guidelines and relevant literature for their applicability to the Belgian situation (registration status, reimbursement, clinical practice) and updated the recommendations for initial monotherapy in adults and children and add-on treatment in adults. Recommendations for add-on treatment in children were also included (not covered in the 2008/2012 publications). Like the 2008/2012 publications, the current update also covers other important aspects related to the management of epilepsy, including the importance of early referral in drug-resistant epilepsy, pharmacokinetic properties and tolerability of AEDs, comorbidities, specific considerations in elderly and pregnant patients, generic substitution and the rapidly evolving field of precision medicine