Human-human haptic collaboration in cyclical Fitts' tasks

Understanding how humans assist each other in haptic interaction teams could lead to improved robotic aids to solo human dextrous manipulation. Inspired by experiments reported in Reed et al. (2004), which suggested two-person haptically interacting teams could achieve a lower movement time (MT) than individuals for discrete aiming movements of specified accuracy, we report that two-person teams (dyads) can also achieve lower MT for cyclical, continuous aiming movements. We propose a model, called endpoint compromise, for how the intended endpoints of both subjects' motion combine during haptic interaction; it predicts a ratio of /spl radic/2 between slopes of MT fits for individuals and dyads. This slope ratio prediction is supported by our data

Software Tools to Support Research on Airport Departure Planning

A simple, portable and useful collection of software tools has been developed for the analysis of airport surface traffic. The tools are based on a flexible and robust traffic-flow model, and include calibration, validation and simulation functionality for this model. Several different interfaces have been developed to help promote usage of these tools, including a portable Matlab‘ implementation of the basic algorithms; a web-based interface which provides online access to automated analyses of airport traffic based on a database of real-world operations data which covers over 250 U.S. airports over a 5-year period; and an interactive simulation-based tool currently in use as part of a college-level educational module. More advanced applications for airport departure traffic include taxi-time prediction and evaluation of “windowing” congestion control

Toxicology of chemical mixtures: international perspective.

This paper reviews major activities outside the United States on human health issues related to chemical mixtures. In Europe an international study group on combination effects has been formed and has started by defining synergism and antagonism. Successful research programs in Europe include the development and application of statistically designed experiments combined with multivariate data analysis and modeling in vitro and in vivo studies on a wide variety of chemicals such as petroleum hydrocarbons, aldehydes, food contaminants, industrial solvents, and mycotoxins. Other major activities focus on the development of safety evaluation strategies for mixtures such as the use of toxic equivalence factors or alternatives such as the question-and-answer approach, fractionation followed by recombination of the mixture in combination with a mixture design, and quantitative structure-activity relationship analysis combined with lumping analysis and physiologically based pharmacokinetic/pharmacodynamic modeling for studying complex mixtures. A scheme for hazard identification and risk assessment of complex mixtures and a consistent way to generate total volatile organic compound values for indoor air have also been developed. Examples of other activities are carcinogenicity studies on complex mixtures (petroleum middle distillates, foundry fumes, pesticides, heterocyclic amines, diesel exhaust, solid particles), neurotoxicity studies of mixtures of solvents alone or in combination with exposure to physical factors, and toxicity studies of outdoor air pollutants, focusing on particulates. Outside the United States, toxicologists and regulators clearly have a growing interest in the toxicology and risk assessment of chemical mixtures

Warming events projected to become more frequent and last longer across Antarctica

Summer temperatures are often above freezing along the Antarctic coastline, which makes ice shelves and coastal snowpacks vulnerable to warming events (understood as periods of consecutive days with warmer than usual conditions). Here, we project changes in the frequency, duration and amplitude of summertime warming events expected until end of century according to two emission scenarios. By using both global and regional climate models, we found that these events are expected to be more frequent and last longer, continent-wide. By end of century, the number of warming events is projected to double in most of West Antarctica and to triple in the vast interior of East Antarctica, even under a moderate-emission scenario. We also found that the expected rise of warming events in coastal areas surrounding the continent will likely lead to enhanced surface melt, which may pose a risk for the future stability of several Antarctic ice shelves

Estimation of toxicity of chemical mixtures through modeling of chemical interactions.

The Agency for Toxic Substances and Disease Registry (ATSDR), in collaboration with the Dutch Organization for Applied Scientific Research (TNO) Nutrition and Food Research Institute, is conducting studies to evaluate the role of chemical interactions in the expression of toxicity from low-level exposure to combinations of chemicals. The goal of this collaborative effort is to use a weight-of-evidence (WOE) approach to estimate joint toxicity of some simple chemical mixtures and to compare the estimations with test results from animal toxicity studies. The WOE approach uses individual chemical dose-response assessments and algorithms that incorporate various assumptions regarding potential chemical interactions. Qualitative evaluations were prepared for binary combinations of chemicals for the effect of butyl hydroxyanisole on di(2-ethylhexyl)phthalate, the effect of stannous chloride on Cd chloride (CdCl2), and the effect of CdCl2 on loperamide. Analyses of these evaluations and their comparison with the conclusions of laboratory animal experiments indicate that the WOE approach can be used to estimate qualitatively the joint toxicity of such simple mixtures. To further test the utility of the WOE approach, qualitative and semiquantitative evaluations were prepared for two chemical mixtures--one with similarly acting halogenated aliphatics (trichloroethylene, tetrachloroethylene, hexachloro-1,3-butadiene[HCBD], and 1,1,2-trichloro-3,3,3-trifluoropropene [TCTFP]) and the other with dissimilarly acting nephrotoxic components (mercuric chloride, lysinolalanine, D-limonene, and HCBD). These two sets of data were used to estimate the overall toxicities of the mixtures using the WOE algorithm for the mixture. The comparison of the results of the estimated toxicity with experimentally determined toxicity of the mixture of similarly acting nephrotoxicants demonstrated that the WOE approach correctly adjusted for the observed interactions in experimental animal studies. However, this was not true for the mixture of dissimilarly acting nephrotoxicants. This could be attributed to the fact that WOE evaluations are based on dose additivity that postulates that all chemicals in a given mixture act in the same way--by the same mechanism--and differ only in their potencies. In these cases the WOE approach evaluations, based on consideration of common mechanisms for simple chemical mixtures, can lead to better estimates of joint toxicity of chemical mixtures than the default assumption of dose additivity. The results also show that the WOE evaluations should be target-organ specific because none of the models tested could approximate the observed responses in organs other than the target organs in the laboratory animal studies

Modeling the Images of Relativistic Jets Lensed by Galaxies with Different Mass Surface Density Distributions

The images of relativistic jets from extragalactic sources produced by gravitational lensing by galaxies with different mass surface density distributions are modeled. In particular, the following models of the gravitational lens mass distribution are considered: a singular isothermal ellipsoid, an isothermal ellipsoid with a core, two- and three-component models with a galactic disk, halo, and bulge. The modeled images are compared both between themselves and with available observations. Different sets of parameters are shown to exist for the gravitationally lensed system B0218+357 in multicomponent models. These sets allow the observed geometry of the system and the intensity ratio of the compact core images to be obtained, but they lead to a significant variety in the Hubble constant determined from the modeling results.Comment: 26 pages, 9 figures, will be published in the Astronomy Letters, 2011, v.37, N4, pp. 233-24

Compound climate-pollution extremes in Santiago de Chile

Cities in the global south face dire climate impacts. It is in socioeconomically marginalized urban communities of the global south that the effects of climate change are felt most deeply. Santiago de Chile, a major mid-latitude Andean city of 7.7 million inhabitants, is already undergoing the so-called “climate penalty” as rising temperatures worsen the effects of endemic ground-level ozone pollution. As many cities in the global south, Santiago is highly segregated along socioeconomic lines, which offers an opportunity for studying the effects of concurrent heatwaves and ozone episodes on distinct zones of affluence and deprivation. Here, we combine existing datasets of social indicators and climate-sensitive health risks with weather and air quality observations to study the response to compound heat-ozone extremes of different socioeconomic strata. Attributable to spatial variations in the ground-level ozone burden (heavier for wealthy communities), we found that the mortality response to extreme heat (and the associated further ozone pollution) is stronger in affluent dwellers, regardless of comorbidities and lack of access to health care affecting disadvantaged population. These unexpected findings underline the need of a site-specific hazard assessment and a community-based risk management.</p

Surface Solar Extremes in the Most Irradiated Region on Earth, Altiplano

Satellites have consistently pointed to the Altiplano of the Atacama Desert as the place on Earth where the world’s highest surface irradiance occurs. This region, near the Tropic of Capricorn, is characterized by its high elevation, prevalent cloudless conditions, and relatively low concentrations of ozone, aerosols, and precipitable water. Aimed at studying the variability of the surface solar irradiance and detecting atmospheric composition changes in the Altiplano, an atmospheric observatory was set up in 2016 at the northwestern border of the Chajnantor Plateau (5,148 m MSL, 22.95°S, 67.78°W, Chile). Here, we report on the first 5 years of measurements at this observatory that establish the Altiplano as the region that receives the highest-known irradiation on Earth and illuminate the unique features of surface solar extremes at high-altitude locations. We found that the global horizontal shortwave (SW) irradiance on the plateau is on average 308 W m−2 (equivalent to an annual irradiation of 2.7 MWh m−2 yr−1, the highest worldwide). We also found that forward scattering by broken clouds often leads to intense bursts of SW irradiance; a record of 2,177 W m−2 was measured, equivalent to the extraterrestrial SW irradiance expected at approximately 0.79 astronomical units (AU) from the Sun. These cloud-driven surface solar extremes occur on the Chajnantor Plateau at a frequency, intensity, and duration not previously seen anywhere in the world, making the site an ideal location for studying the response of photovoltaic (PV) power plants to periods of enhanced SW variability.</p