A Business Figure In Crisis Time: Independent Financial Adviser

The figure of the Independent Financial Adviser (IAF) is becoming increasingly relevant in the field of business and finance. However, this figure is relatively new, poorly understood by most investors and uncommon in financial institutions. The purpose of this paper is to determine the factors behind the willingness to pay for the services of an independent financial adviser, as well as the reasons that would lead investors to move from the traditional advisors to the independent ones. We have surveyed over 10,000 potential investors in Spain. Thus, the results are consistent from a statistical point of view

Are Men And Women Different In European Higher Education Area?

One of the principles of universities is to include and promote teaching and research in gender equality and non discrimination in all academic fields of training. But this is not easy to measure. This paper proposes a qualitative methodology to measure the problem and applies it to the University of Castilla-La Mancha (Spain)

An Alternative To Test Independence Between Expectations And Disconfirmation Versus The Positive Version Of The Assimilation Theory. An Application To The Case Of Cultural/Heritage Tourism

Despite the emergence of new strategies, models of expectancy/disconfirmation are still very popular in tourist research. This is why they are revisited by presenting an alternative for testing independence between expectations and disconfirmation versus what we call the positive version of the assimilation theory. A derivation of the chi-square statistic including an asymmetric continuity correction is provided to carry out such a test.  This article relies on the information given by 1,500 respondents who were given a small questionnaire specially designed to measure tourist satisfaction in the emblematic part of Toledo, Spain (a UNESCO World Heritage City)

Measuring The Factors Involved In The Time Spent In Educational Childcare

Parents play an extremely important role in their childrens lives and a plethora of research indicates that parents involvement is significantly related to positive child outcomes: Boys who feel that their parents devote time, especially to talk to them about their worries, school work and social lives, almost all emerge as motivated and optimistic men. More specifically, parents involvement in childrens education at age 7 predicts higher educational attainment by age 20, in both boys and girls. Thus, parents involvement in children's education being considered a core factor for success in undergraduate education, in this paper we study the effect of parental socio-educational level on the time they spend in primary educational childcare (reading to children, teaching children, assistance with homework, attending meetings at a child's school, etc.). Given the low rate of success in the Spanish undergraduate education, we focus on the Spanish case. We focus on the Spanish case because we suspect that this factor can be one of the reasons for the low rate of success in the universities. Our study is based on the data provided by the Spanish Time Use Survey 2009-2010

Pollution And Environmental Indicators Using A Multicriteria Analysis

Pollution and environmental factors are a core topic because they influence in air quality of the different areas of a city. This is why in this article we propose to apply a multicriteria decision aid method (the Promethee) to establish a ranking among twenty one districts of Madrid city. To develop this ranking we use objective and subjective criteria that contain information about pollution and environmental indicators in these districts. The results show that some districts are the worse and the best regardless the used criteria

Detecting Successful Student Profiles At An Open University: The Case Of The UNED (Spain)

At present, one of the major issues and most interesting discussions within the European Higher Education Area is the rate of success in university-level study, and therefore the adaptation of todays university education system to societys requirements. Moreover, we have seen significant growth in distance education throughout recent decades, as this type of education takes on a stronger leadership role in countries that are experiencing severe economic crises. Because the National Distance Education University (UNED) is the most important distance university in Spain, and the Economics Degree program has been offered by the School of Economics and Business for the first time, we have attempted to find a correlation between variables which describe student characteristics (age, gender, employment status, manner of admission, and nationality) and success rates in order to determine the influence that these variables have and achieve a better understanding of student success rates

Cooperative Learning In Virtual Environments: The Jigsaw Method In Statistical Courses

This document sets out a novel teaching methodology as used in subjects with statistical content, traditionally regarded by students as difficult. In a virtual learning environment, instructional techniques little used in mathematical courses were employed, such as the Jigsaw cooperative learning method, which had to be adapted to the peculiarities of the subject. The aim of this methodological project is to adapt the teaching of statistical courses to the new European Higher Education Area

Presence and stability of rotors in atrial fibrillation: evidence and therapeutic implications

[EN] Rotor-guided ablation has opened new perspectives into the therapy of atrial fibrillation (AF). Analysis of the spatio-temporal cardiac excitation patterns in the frequency and phase domains has demonstrated the importance of rotors in research models of AF, however, the dynamics and role of rotors in human AF are still controversial. In this review, the current knowledge gained through research models and patient data that support the notion that rotors are key players in AF maintenance is summarized. We report and discuss discrepancies regarding rotor prevalence and stability in various studies, which can be attributed in part to methodological differences among mapping systems. Future research for validation and improvement of current clinical electrophysiology mapping technologies will be crucial for developing mechanistic-based selection and application of the best therapeutic strategy for individual AF patient, being it, pharmaceutical, ablative, or other approach.This work was supported in part by grants from the Instituto de Salud Carlos III (Ministry of Economy and Competitiveness, Spain: PI13-01882, PI13-00903, and PI14/00857), Spanish Society of Cardiology (Clinical Research Grant 2015), Generalitat Valenciana (ACIF/2013/021), Innovation (Red RIC, PLE2009-0152), and NHLBI (P01-HL039707, P01-HL087226, and R01-HL118304).Guillem Sánchez, MS.; Climent, AM.; Rodrigo Bort, M.; Fernandez-Aviles, F.; Atienza, F.; Berenfeld, O. (2016). Presence and stability of rotors in atrial fibrillation: evidence and therapeutic implications. Cardiovascular Research. 109(4):480-492. https://doi.org/10.1093/cvr/cvw011S480492109

Including Functional Annotations and Extending the Collection of Structural Classifications of Protein Loops (ArchDB)

Loops represent an important part of protein structures. The study of loop is critical for two main reasons: First, loops are often involved in protein function, stability and folding. Second, despite improvements in experimental and computational structure prediction methods, modeling the conformation of loops remains problematic. Here, we present a structural classification of loops, ArchDB, a mine of information with application in both mentioned fields: loop structure prediction and function prediction. ArchDB (http://sbi.imim.es/archdb) is a database of classified protein loop motifs. The current database provides four different classification sets tailored for different purposes. ArchDB-40, a loop classification derived from SCOP40, well suited for modeling common loop motifs. Since features relevant to loop structure or function can be more easily determined on well-populated clusters, we have developed ArchDB-95, a loop classification derived from SCOP95. This new classification set shows a ~40% increase in the number of subclasses, and a large 7-fold increase in the number of putative structure/function-related subclasses. We also present ArchDB-EC, a classification of loop motifs from enzymes, and ArchDB-KI, a manually annotated classification of loop motifs from kinases. Information about ligand contacts and PDB sites has been included in all classification sets. Improvements in our classification scheme are described, as well as several new database features, such as the ability to query by conserved annotations, sequence similarity, or uploading 3D coordinates of a protein. The lengths of classified loops range between 0 and 36 residues long. ArchDB offers an exhaustive sampling of loop structures. Functional information about loops and links with related biological databases are also provided. All this information and the possibility to browse/query the database through a web-server outline an useful tool with application in the comparative study of loops, the analysis of loops involved in protein function and to obtain templates for loop modeling

The Release of Soluble Factors Contributing to Endothelial Activation and Damage after Hematopoietic Stem Cell Transplantation Is Not Limited to the Allogeneic Setting and Involves Several Pathogenic Mechanisms

AbstractThis study evaluated the relative impact of the intensity of the conditioning regimen and the alloreactivity in the endothelial dysfunction occurring after allogeneic hematopoietic stem cell transplantation (allo-HSCT). It involved a comparative analysis of the effect of incubating human umbilical vein endothelial cells (ECs) with serum samples from patients receiving autologous HSCT (auto-HSCT) or unrelated donor allo-HSCT. In both groups, blood samples were collected through a central line before conditioning (Pre), before transplantation (day 0), and at days 7, 14, and 21 after transplantation. Changes in the expression of EC receptors and adhesion proteins, adhesion of leukocytes and platelets under flow, and signaling pathways were analyzed. Endothelial activation and damage were observed in both groups, but with differing patterns. All markers of endothelial dysfunction demonstrated a progressive increase from day Pre to day 14 in the auto-HSCT group and exhibited 2 peaks of maximal expression (at days 0 and 21) in the allo-HSCT group. Both treatments induced a proinflammatory state (ie, expression of adhesion receptors, leukocyte adhesion, and p38 MAPK activation) and cell proliferation (ie, morphology and activation of ErK42/44). Prothrombotic changes (ie, von Willebrand factor expression and platelet adhesion) predominated after allo-HSCT, and a proapoptotic tendency (ie, activation of SAPK/JNK) was seen only in this group. These findings indicate that endothelial activation and damage after HSCT also occur in the autologous setting and affect macrovascular ECs. After the initial damage induced by the conditioning regimen, other factors, such as granulocyte colony-stimulating factor (G-CSF) toxicity, engraftment, and alloreactivity, may contribute to the endothelial damage seen during HSCT. Further studies are needed to explore the association between this endothelial damage and the vascular complications associated with HSCT