62,494 research outputs found
Implementation of environmental recovery training response to biological incidents in a human health degree
Agents involved in biological incidents and outbreaks of infection can spread easily, so response teams are required to quickly implement a recovery plan to decontaminate and restore the environment impacted by these incidents to minimise public risks. A group of academics at De Montfort University (DMU, UK), with support from first responders during the 2014-16 Ebola outbreak, are developing appropriate training to provide basic skills so human health science students can respond to biological incidents. Following the competences identified by the European Commission, we have created key competences for these students based on the core skills that any medical first responder to biological emergencies should have. To provide students with the key competences related to environmental planning, we have created specific training that consisted of a 2 hours practical plus theory related to emerging diseases and the international response provided to tackle the Ebola pandemic. The practical component was a research-led workshop to develop a complete protection and recovery plan to respond to an outbreak of infection by Cyclospora cayetanensis in an urban area. Students used the novel methodology developed by Public Health England [âUK Recovery Handbook for Biological Incidentsâ (Pottage et al., 2015)] [1] to select appropriate options or techniques to protect and recover the affected environment, according to the physiological characteristics of the biological agent/microorganism involved and the environment impacted. Critical thinking and discussion is also needed to select recovery options (R.O.), e.g. use of chlorine-based decontamination liquids as part of the R.O. âreactive liquidsâ will have limited efficacy as oocysts of Cyclospora are resistant to these. After successful testing of the training with postgraduate students, we introduced it in a level 6 module in the DMU degree programme BMedSci in Medical Science in 2016/17 (n=24). A small proportion of these BMedSci students reported that they did not enjoy (13.4%) or were not satisfied (20%) with the training provided, which could be attributed to the fact that the topic of the training (environmental sciences) was not of direct interest for these students who are studying a degree more related to medicine. However, despite the short duration of the training, students were able to tailor an appropriate response with the resources and information provided (physiological characteristics and a literature review on decontamination/inactivation techniques for Cyclospora was provided to overcome time constraints). Specifically, 73.3% indicated that they gained some public health prevention/preparedness knowledge against a biological incident; 80% highlighted that they learnt how to establish some public health interventions; and 60% learnt how to tailor a recovery plan. A few students (20%) had difficulties with the recovery concepts and the interpretation of the physiological characteristics, which may be attributed to limited background knowledge of microbiology and parasitology (as the BMedSci programme does not have a complete module dedicated to the study of these topics). In conclusion, the increased prevalence of biological contamination incidents necessitates development of appropriate training to include environmental decontamination strategies to protect human health. The short teaching intervention described in this paper could be used to easily address this necessity
Assessment of the worthwhileness of efficient driving in railway systems with high-receptivity power supplies
Eco-driving is one of the most important strategies for significantly reducing the energy consumption of railways with low investments. It consists of designing a way of driving a train to fulfil a target running time, consuming the minimum amount of energy. Most eco-driving energy savings come from the substitution of some braking periods with coasting periods. Nowadays, modern trains can use regenerative braking to recover the kinetic energy during deceleration phases. Therefore, if the receptivity of the railway system to regenerate energy is high, a question arises: is it worth designing eco-driving speed profiles? This paper assesses the energy benefits that eco-driving can provide in different scenarios to answer this question. Eco-driving is obtained by means of a multi-objective particle swarm optimization algorithm, combined with a detailed train simulator, to obtain realistic results. Eco-driving speed profiles are compared with a standard driving that performs the same running time. Real data from Spanish high-speed lines have been used to analyze the results in two case studies. Stretches fed by 1 Ă 25 kV and 2 Ă 25 kV AC power supply systems have been considered, as they present high receptivity to regenerate energy. Furthermore, the variations of the two most important factors that affect the regenerative energy usage have been studied: train motors efficiency ratio and catenary resistance. Results indicate that the greater the catenary resistance, the more advantageous eco-driving is. Similarly, the lower the motor efficiency, the greater the energy savings provided by efficient driving. Despite the differences observed in energy savings, the main conclusion is that eco-driving always provides significant energy savings, even in the case of the most receptive power supply network. Therefore, this paper has demonstrated that efforts in improving regenerated energy usage must not neglect the role of eco-driving in railway efficiency
Effects of percentage of blockage and flameholder downstream counterbores on lean combustion limits of premixed, prevaporized propane-air mixture
Lean combustion limits were determined for a premixed prevaporized propane air mixture with flat plate flame stabilizers. Experiments were conducted in a constant area flame tube combustor utilizing flameholders of varying percentages of blockage and downstream counterbores. Combustor inlet air velocity at ambient conditions was varied from 4 to 9 meters per second. Flameholders with a center hole and four half holes surrounding it were tested with 63, 73, and 85 percent blockage and counterbore diameters of 112 and 125 percent of the thru hole diameter, in addition to the no counterbore configuration. Improved stability was obtained by using counterbore flameholders and higher percentages of blockage. Increases in mixture velocity caused the equivalence ratio at blowout to increase in all cases
convergence result for nonlocal elliptic-type problems via Tartar's method
In this work we obtain a compactness result for the convergence of a
family of nonlocal and nonlinear monotone elliptic-type problems by means of
Tartar's method of oscillating test functions.Comment: In this revision we added a new section that shows the
Gamma-convergence of the associated energy functional
Results on a pedagogic approach for tailoring public health interventions to minimise opportunistic infections.
We are performing curriculum modifications on the first year BSc (Hons) Biomedical Science module âBasic Microbiologyâ (De Montfort University, UK) to increase studentsâ knowledge of basic medical parasitology and infectious diseases, so these students can acquire the necessary skills to tackle their final degree module âMedical Microbiologyâ. Following student feedback on a novel short intervention in 2017/18 to promote awareness about human immunodeficiency virus (HIV), we have created an engaging workshop session to cover not only HIV but also the opportunistic infections that can affect HIV patients that have developed acquired immune deficiency syndrome (AIDS) and how to prevent them. The objective of this work was to evaluate the effectiveness of the improved workshop developed and to collect studentsâ impressions to perform further modifications if needed. Briefly, students were required to develop public health measures for HIV positive patients with two different degrees of immunosuppression (i.e. with CD4+ T cells in peripheral blood above and below 200 cells/ÎŒl) to prevent exposure and infection from opportunistic pathogens such as Cryptosporidium spp., Toxoplasma gondii or Pneumocystis jirovecii from: a) sexual exposures; b) intravenous drug use; b) environment and work; c) food and water; d) foreign travel. Students, following evidence-based public health methodology, tailored their measures or interventions using the most up-to-date information reported in the literature regarding HIV chemoprophylaxis and recent guidelines published by US Department of Health and Human Services on HIV/AIDS treatment and prevention. Interventions were critically analysed with all students in the last 20 min. of the workshop, which was repeated several times due to the number of students (n=203). The objectives of this workshop were evaluated by careful analysis of a specific feedback questionnaire (n=46 out of 203) voluntarily completed by students at the end of the workshop. The questionnaire showed the following feedback: 80.4% (65.2% agreed; 15.2% strongly agreed) indicated that they learnt how to identify public health interventions; and 95.7% (56.5% agreed; 39.1% strongly agreed) indicated that they would be able to establish measures to reduce HIV transmission and prevent opportunistic infections. Additionally, 95.7% (39.1% agreed; 56.5% strongly agreed) indicated that the workshop helped them to understand the relevance of local and global interventions. Finally, 97.8% of responders considered that the content (52.2% agreed; 45.7% strongly agreed) and duration (60.9% agreed; 37% strongly agreed) of the workshop was appropriate; and 89.1% (58.7% agreed; 30.4% strongly agreed) and 73.9% (41.3% agreed; 32.6% strongly agreed) enjoyed and were satisfied with the workshop provided, respectively. In conclusion, the improved workshop developed would seem to be effective for promoting sexual and public health education to minimise opportunistic pathogen infections in relevant patients when delivered to students with a basic knowledge of microbiology and parasitology
Pairing Correlations in Finite Systems: From the weak to the strong fluctuations regime
The Particle Number Projected Generator Coordinate Method is formulated for
the pairing Hamiltonian in a detailed way in the projection after variation and
the variation after projection methods. The dependence of the wave functions on
the generator coordinate is analyzed performing numerical applications for the
most relevant collective coordinates. The calculations reproduce the exact
solution in the weak, crossover and strong pairing regimes. The physical
insight of the Ansatz and its numerical simplicity make this theory an
excellent tool to study pairing correlations in complex situations and/or
involved Hamiltonians.Comment: Submitted to EPJ
Upper Energy Limit of Heavy Baryon Chiral Perturbation Theory in Neutral Pion Photoproduction
With the availability of the new neutral pion photoproduction from the proton
data from the A2 and CB-TAPS Collaborations at Mainz it is mandatory to revisit
Heavy Baryon Chiral Perturbation Theory (HBChPT) and address the extraction of
the partial waves as well as other issues such as the value of the low-energy
constants, the energy range where the calculation provides a good agreement
with the data and the impact of unitarity. We find that, within the current
experimental status, HBChPT with the fitted LECs gives a good agreement with
the existing neutral pion photoproduction data up to 170 MeV and that
imposing unitarity does not improve this picture. Above this energy the data
call for further improvement in the theory such as the explicit inclusion of
the \Delta (1232). We also find that data and multipoles can be well described
up to 185 MeV with Taylor expansions in the partial waves up to first
order in pion energy.Comment: 6 pages, 5 figures, version to be published in Physics Letters
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