Uniform planarization technique for the realization of a twin-guide membrane laser

The InP Membrane on Silicon (IMOS) generic technology promises high index contrast photonic integrated circuits. To make this a reality fabrication of an electrically pumped twin-guide laser is pursued. In this paper, one of the bottle-necks for the processing is discussed, the planarization step and subsequent etch-back. Benzocyclobutene (BCB) is used to planarize SOA structures before contacting. Complete curing of BCB at 280oC creates uniformity issues during etch-back. To mitigate this, a partial cure at 180oC before the etch-back and a complete cure afterwards is performed. Experiments show repeatability and reproducibility. Good uniformity after etch-back is found

Comments on multiple scattering of high-energy muons in thick layers

We describe two independent methods to calculate the angular distribution of muons after traversing a thick scatterer due to multiple Coulomb scattering. Both methods take into account the nuclear size effect. We demonstrate a necessity to account for the nucleus extension as well as incoherent scattering on atomic electrons to describe the muon scattering at large angles in thick matter layers. The results of the two methods of calculations are in good agreement.Comment: 22 pages, 5 figures, submitted to Nucl. Instrum. and Met

Loop bounds on non-standard neutrino interactions

We reconsider the bounds on non-standard neutrino interactions with matter which can be derived by constraining the four-charged-lepton operators induced at the loop level. We find that these bounds are model dependent. Naturalness arguments can lead to much stronger constraints than those presented in previous studies, while no completely model-independent bounds can be derived. We will illustrate how large loop-contributions to four-charged-lepton operators are induced within a particular model that realizes gauge invariant non-standard interactions and discuss conditions to avoid these bounds. These considerations mainly affect the $\mathcal O(10^{-4})$ constraint on the non-standard coupling strength \eps_{e\mu}, which is lost. The only model-independent constraints that can be derived are $\mathcal O(10^{-1})$. However, significant cancellations are required in order to saturate this bound.Comment: Minor changes, version to be published in JHEP. 17 pages, 3 Axodraw figures, REVTeX

Magnetic force microscopy of single-domain cobalt dots patterned using interference lithography

We have fabricated arrays of Co dots of diameters 100 and 70 nm using interference lithography. Density of these arrays is 7.2x10{sup 9}/in{sup 2}. Magnetic force microscopy indicate that the Co dots are single domain with moments that can be controlled to point either in-plane or out-of-plane. Interference lithography is a process that is easily scaled to large areas and is potentially capable of high throughput. Large, uniform arrays of single-domain structures are potentially useful for high-density, low-noise data storage

Optimized Two-Baseline Beta-Beam Experiment

We propose a realistic Beta-Beam experiment with four source ions and two baselines for the best possible sensitivity to theta_{13}, CP violation and mass hierarchy. Neutrinos from 18Ne and 6He with Lorentz boost gamma=350 are detected in a 500 kton water Cerenkov detector at a distance L=650 km (first oscillation peak) from the source. Neutrinos from 8B and 8Li are detected in a 50 kton magnetized iron detector at a distance L=7000 km (magic baseline) from the source. Since the decay ring requires a tilt angle of 34.5 degrees to send the beam to the magic baseline, the far end of the ring has a maximum depth of d=2132 m for magnetic field strength of 8.3 T, if one demands that the fraction of ions that decay along the straight sections of the racetrack geometry decay ring (called livetime) is 0.3. We alleviate this problem by proposing to trade reduction of the livetime of the decay ring with the increase in the boost factor of the ions, such that the number of events at the detector remains almost the same. This allows to substantially reduce the maximum depth of the decay ring at the far end, without significantly compromising the sensitivity of the experiment to the oscillation parameters. We take 8B and 8Li with gamma=390 and 656 respectively, as these are the largest possible boost factors possible with the envisaged upgrades of the SPS at CERN. This allows us to reduce d of the decay ring by a factor of 1.7 for 8.3 T magnetic field. Increase of magnetic field to 15 T would further reduce d to 738 m only. We study the sensitivity reach of this two baseline two storage ring Beta-Beam experiment, and compare it with the corresponding reach of the other proposed facilities.Comment: 17 pages, 3 eps figures. Minor changes, matches version accepted in JHE

Clinical Scholars: Making Equity, Diversity and Inclusion Learning an Integral Part of Leadership Development

The plethora of persistent and pervasive health inequities in the United States is a Wicked Problem which threatens the health and wellbeing of all people. To dismantle them is no easy task, and requires a health care workforce practiced in leadership skill sets embracing a deep focus on areas of equity, diversity and inclusion (EDI). This chapter describes how the core competencies and curriculum of the Clinical Scholars Program have been designed to offer this set of skills. To start, the program’s foundational set of 25 competencies cover four domains (Personal, Interpersonal, Organizational, and Community & Systems) and include both more traditional leadership competencies as well as contemporary competencies focused on equity, diversity, and inclusion. The curriculum takes the set of 25 leadership and EDI competencies and breaks them down into learning sessions where participants listen, practice, and apply the ideas, behaviors, and mindsets. The leadership core and the EDI core of the curriculum exist both in tandem and in unison to provide the full Clinical Scholars experience. At times, sessions focus on one core or the other, and at times, both leadership and EDI are present in the learning of a session. Example learning sessions for each core and the weaving of the cores together are provided. Four challenges to creating an equity-centered leadership program are identified: 1. The personalized nature of the journey of self-development; 2. Shifting Mindsets and Skill Sets; 3. Piloting an evidence-based curriculum on EDI; and 4. Maintaining engagement with participants over time and across distance. A set of top recommendations for weaving EDI and Leadership learning are also offered. The chapter details the importance of meaningfully focusing on EDI when tackling modern, wicked problems

Clinical Scholars: Using Program Evaluation to Inform Leadership Development

Leadership development programs are notoriously difficult to evaluate, and when evaluations are attempted, they often do not go beyond measuring low-level, short-term outcomes of the impacts experienced by participants. Many leadership development programs do not systematically assess changes that are catalyzed within the organizations, communities and systems in which participants lead. To address these challenges, evaluators of the Clinical Scholars National Leadership Institute (CNLI) have designed a comprehensive, mixed-methods evaluation approach to determine the effectiveness of the training and explore the impacts of participants in the spheres in which they lead. Guided by Michael Patton’s Developmental Evaluation approach and framed by Kirkpatrick’s Training Evaluation Model, the CSNLI evaluation collects data on multiple levels to provide a robust picture of the multiple outcomes of the program. The approach focuses on individual participant outcomes, by measuring competency changes over time and exploring how participants use the competencies gained through the training in their work. Social network analysis is utilized to measure the development and expansion of participants’ networks and collaboration within the teams, cohorts, and across sectors and disciplines throughout their time in the CSNLI. The Most Significant Change methodology and semi-structured alumni interviews are used to measure impacts participants identify as occurring as a result of their participation. Finally, Concept Mapping is implemented to explore how Fellows make meaning of the foundational concepts and values of the CSNLI. The outcome and impact evaluation activities employed by the CSNLI, in combination with quality improvement-focused process evaluation, support innovation and excellence in the provision of a health equity-grounded leadership development program

Clinical Scholars: Effective Approaches to Leadership Development

The Clinical Scholars (CS) National Leadership Institute (CSNLI) equips interprofessional teams of health care professionals through equity-centered leadership training, preparing them to be change leaders working to advance health equity in communities across the US and its territories. At the time of this writing, four cohorts consisting of 131 Fellows from 14 different disciplines, participating in 36 different teams of two to five members are working on “Wicked Problem Impact Projects”, an implementation science-based approach to action learning projects. This chapter reports on the design of the 3-year CS experience, the onsite and distance-based training support, and the subsequent learning responses of 98 participants, 30 of whom had completed the 3-year training (Cohort 1), 34 of whom had completed 2-years of the training (Cohort 2), and 34 who had completed 1-year of the training (Cohort 3). The training program is guided by 25 competencies that weave leadership and equity throughout, which are divided into four families: Personal, Interpersonal, Organizational, and Community & Systems. Learning outcomes indicated that Fellows are highly satisfied, with all participants rating their experience at 6.10-6.77 on a 7-point scale across all sessions, all years. Retrospective pre-and post-tests assessed learning gains on the competencies, indicating statistically significant changes from baseline to midpoint in participant knowledge, attitude, use, and self-efficacy in each of the 25 competencies and large and significant gains by competency family. The Clinical Scholars Program presents an in-depth, longitudinal, state-of-the-art approach to promoting the cultivation and development of a large and sophisticated set of skills that intentionally integrate leadership competencies with a focus on health equity. Taken together, these outcomes show how a logical and structured process, using widely available tools, can contribute to both learning and implementation of skills that lead to real world impacts in communities. Given the results reported at the close of their Clinical Scholars experience, the data suggest that investing in robust, intensive leadership development of interprofessional teams is a smart decision for impacting the culture of health in communities nationwide

Effect of lurbinectedin on the QTc interval in patients with advanced solid tumors: an exposure–response analysis

Purpose: This study assessed the effect of lurbinectedin, a highly selective inhibitor of oncogenic transcription, on the change from baseline in Fridericia’s corrected QT interval (¿QTcF) and electrocardiography (ECG) morphological patterns, and lurbinectedin concentration–¿QTcF (C-¿QTcF) relationship, in patients with advanced solid tumors. Methods: Patients with QTcF = 500 ms, QRS < 110 ms, PR < 200 ms, and normal cardiac conduction and function received lurbinectedin 3.2 mg/m2 as a 1-h intravenous infusion every 3 weeks. ECGs were collected in triplicate via 12-lead digital recorder in treatment cycle 1 and 2 and analyzed centrally. ECG collection time-matched blood samples were drawn to measure lurbinectedin plasma concentration. No effect on QTc interval was concluded if the upper bound (UB) of the least square (LS) mean two-sided 90% confidence intervals (CI) for ¿QTcF at each time point was < 20 ms. C-¿QTcF was explored using linear mixed-effects analysis. Results: A total of 1707 ECGs were collected from 39 patients (females, 22; median age, 56 years). The largest UB of the 90% CI of ¿QTcF was 9.6 ms, thus lower than the more conservative 10 ms threshold established at the ICH E14 guideline for QT studies in healthy volunteers. C-¿QTcF was better fit by an effect compartment model, and the 90% CI of predicted ¿QTcF at Cmax was 7.81 ms, also below the 10 ms threshold of clinical concern. Conclusions: ECG parameters and C-¿QTcF modelling in this prospective study indicate that lurbinectedin was not associated with a clinically relevant effect on cardiac repolarization