24,339 research outputs found

    Joins of DGA modules and sectional category

    Get PDF
    We construct an explicit semifree model for the fiber join of two fibrations p: E --> B and p': E' --> B from semifree models of p and p'. Using this model, we introduce a lower bound of the sectional category of a fibration p which can be calculated from any Sullivan model of p and which is closer to the sectional category of p than the classical cohomological lower bound given by the nilpotency of the kernel of p^*: H^*(B;Q) --> H^*(E;Q). In the special case of the evaluation fibration X^I --> X x X we obtain a computable lower bound of Farber's topological complexity TC(X). We show that the difference between this lower bound and the classical cohomological lower bound can be arbitrarily large.Comment: This is the version published by Algebraic & Geometric Topology on 24 February 200

    A, B, C's (and D)'s for Understanding VARs

    Get PDF
    The dynamics of a linear (or linearized) dynamic stochastic economic model can be expressed in terms of matrices (A,B,C,D) that define a state space system. An associated state space system (A,K,C,Sigma) determines a vector autoregression for observables available to an econometrician. We review circumstances under which the impulse response of the VAR resembles the impulse response associated with the economic model. We give four examples that illustrate a simple condition for checking whether the mapping from VAR shocks to economic shocks is invertible. The condition applies when there are equal numbers of VAR and economic shocks.

    Gene discovery in developmental neuropsychiatric disorders : clues from chromosomal rearrangements

    Get PDF

    Education, Employment, and Coastal Carolina University: What Are CCU Students\u27 Plans After Graduation?

    Get PDF
    The Bureau of Labor Statistics has shown that while unemployment amongst young college graduates is high, joblessness decreases as students pursue post-baccalaureate degrees. And with national unemployment near 8 percent, it is important for college students to consider what obstacles they may face when entering the workforce. Challenges may include sociohistorical (parent educational attainment) and socioeconomic factors as well as obstacles surrounding various forms of human capital. Using some of these challenges youth face when entering college and/or the workforce, this study predicts the decisions Coastal Carolina University (CCU) students will make post-graduation based upon four elements: parental education, academic achievement, paid work, and faculty-student interaction. I survey a random sample of CCU students assessing future occupational and/or educational plans post-baccalaureate graduation. Overall, the results show that the four selected elements accurately predict CCU student choice after graduation: whether they will enter a graduate program or enter the workforce. Considering, then, that unemployment risks decrease as education beyond a bachelor’s degree increases, CCU faculty have a unique opportunity to shape the economy by encouraging students to pursue schooling post-baccalaureate graduation

    A, B, C’s (And D’s) For Understanding VARS

    Get PDF
    The dynamics of a linear (or linearized) dynamic stochastic economic model can be expressed in terms of matrices (A,B,C,D) that define a state space system. An associated state space system (A,K,C, Sigma) determines a vector autoregression for observables available to an econometrician. We review circumstances under which the impulse response of the VAR resembles the impulse response associated with the economic model. We give four examples that illustrate a simple condition for checking whether the mapping from VAR shocks to economic shocks is invertible. The condition applies when there are equal numbers of VAR and economic shocks.VARs , Invertibility, Estimation of Dynamic Equilibrium Models, economic shocks, innovations

    DY determinants, possibly associated with novel class II molecules, stimulate autoreactive CD4+ T cells with suppressive activity

    Get PDF
    A set of T cell clones (TCC) isolated from HLA-DR-, Dw-, DQ-matched allogeneic MLCs was found to proliferate autonomously when stimulated with cells carrying a wide range of class I or II specificities. This apparently unrestricted proliferation was relatively weak, and only low levels of IL-2 were present in the supernatants of stimulated cells. Autologous as well as allogeneic PBMC and B lymphoblastoid cell lines (B-LCL) were capable of stimulating such clones, which were also restimulated by suppressive, but not by helper, TCC. Moreover, such clones displayed the unusual property of autostimulation. mAb inhibition experiments suggested that class II- or class II-restricted antigens were involved in stimulation. Thus, certain "broad" mAbs (TU39, SG520) reacting with multiple locus products inhibited activation of these reagents, but none of those reacting more specifically with DR (TU34, TU37, L243, Q2/70, SG157), DQ (TU22, SPV- L3, Leu 10), or DP (B7/21), or mixtures of these mAbs, were able to do so. Evidence from sequential immunoprecipitation experiments suggested that mAb TU39 bound class II-like molecules other than DR, DQ, and DP on TCC and B-LCL, and it is therefore proposed that such putative novel class II-like molecules may carry the stimulating determinants for these autoreactive clones. DY-reactive clones lacked helper activity for B cells but mediated potent suppressive activity on T cell proliferative responses that was not restricted by the HLA type of the responding cells. Suppressive activity was induced in normal PBMC by such clones, as well as by independent suppressive clones, which was also inhibited only by mAb TU39. These findings lead to the proposal that DY-reactive autostimulatory cells may constitute a self- maintaining suppressive circuit, the level of activity of which would be regulated primarily by the availability of IL-2 in the microenvironmen

    The Elusive Target of IT Project Success

    Get PDF

    The great Fed pivot

    Get PDF
    corecore