Biblioteca pública como dispositivo de transformação social e a Agenda 2030

The work presents a study on the public library, its potential and the 2030 Agenda of the United Nations. Therefore, a bibliographic search was conducted in the Information Science Database (BRAPCI) and in the repository of the Brazilian Federation of Librarians, Information Scientists, and Institutions Associations (FEBAB) to find publications with dates between 2015 and 2021. From this search, some scientific productions that present actions developed by public libraries to achieve the Sustainable Development Goals proposed by Agenda 2030 were selected. This bibliographic material was analyzed to know how public libraries have been leading the social transformation of their communities based on the Sustainable Development Goals of the 2030 Agenda. It was concluded that the actions developed by public libraries to meet the SDGs are important and that other libraries should get involved in this campaign and disseminate their actions and results to inspire new actions.O trabalho apresenta um estudo a respeito da biblioteca pública, suas potencialidades e a Agenda 2030 da Organização das Nações Unidas. Para tanto realizou-se uma pesquisa bibliográfica na Base de Dados em Ciência da Informação (BRAPCI) e no repositório da Federação Brasileira de Associações de Bibliotecários, Cientistas da Informação e Instituições (FEBAB) a fim de encontrar publicações com datas entre 2015 e 2021. A partir dessa busca selecionou-se produções científicas que apresentam ações desenvolvidas por bibliotecas públicas para alcançar os Objetivos de Desenvolvimento Sustentável (ODS) propostos na Agenda 2030. Realizou-se a análise desse material bibliográfico para conhecer como as bibliotecas públicas têm protagonizado a transformação social de suas comunidades a partir dos Objetivos de Desenvolvimento Sustentável da Agenda 2030. Concluiu-se que as ações desenvolvidas nas bibliotecas públicas para atender as ODS são importantes e que outras bibliotecas devem se envolver nesta campanha e divulgar suas ações e resultados de modo a inspirar novas ações

The Synthetic Peptide LyeTx I mn∆K, Derived from <i>Lycosa erythrognatha</i> Spider Toxin, Is Active against Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) In Vitro and In Vivo

The urgent global health challenge posed by methicillin-resistant Staphylococcus aureus (MRSA) infections demands effective solutions. Antimicrobial peptides (AMPs) represent promising tools of research of new antibacterial agents and LyeTx I mn∆K, a short synthetic peptide based on the Lycosa erythrognatha spider venom, is a good representative. This study focused on analyzing the antimicrobial activities of LyeTx I mn∆K, including minimum inhibitory and bactericidal concentrations, synergy and resensitization assays, lysis activity, the effect on biofilm, and the bacterial death curve in MRSA. Additionally, its characterization was conducted through isothermal titration calorimetry, dynamic light scattering, calcein release, and finally, efficacy in a mice wound model. The peptide demonstrates remarkable efficacy against planktonic cells (MIC 8–16 µM) and biofilms (>30% of inhibition) of MRSA, and outperforms vancomycin in terms of rapid bactericidal action and anti-biofilm effects. The mechanism involves significant membrane damage. Interactions with bacterial model membranes, including those with lysylphosphatidylglycerol (LysylPOPG) modifications, highlight the versatility and selectivity of this compound. Also, the peptide has the ability to sensitize resistant bacteria to conventional antibiotics, showing potential for combinatory therapy. Furthermore, using an in vivo model, this study showed that a formulated gel containing the peptide proved superior to vancomycin in treating MRSA-induced wounds in mice. Together, the results highlight LyeTx I mnΔK as a promising prototype for the development of effective therapeutic strategies against superficial MRSA infections