2 research outputs found

    <span style="font-size:11.0pt;mso-bidi-font-size: 10.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:AR-SA" lang="EN-US">An overview on phytopharmacology of <i>Pelargonium graveolens </i>L.</span>

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    558-563<span style="font-size:11.0pt;mso-bidi-font-size: 10.0pt;font-family:" times="" new="" roman","serif";mso-fareast-font-family:"times="" roman";="" mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="" lang="EN-US">Since ancient, Pelargonium graveolens L. is well organized for its therapeutic values. Only recently, its new medicinal aspects have been award by scientists. Regarding new multi-functional properties of P. graveolens and valuable ongoing reports we were prompted to update phytochemistry and pharmacology of it. Data were collected using of journals, articles, scientific books and websites such as Scopus and PubMed. P. graveolens extracts and essential oil are important in drug development with many pharmacologic properties in China and Middle East especially in Egypt and Morocco. P. graveolens has been used in traditional medicine for the relief of hemorrhoids, dysentery, inflammation and cancer<span style="font-size:11.0pt; mso-bidi-font-size:10.0pt;font-family:" times="" new="" roman","serif";mso-fareast-font-family:="" "times="" roman";mso-ansi-language:en-us;mso-fareast-language:en-us;="" mso-bidi-language:ar-sa"="" lang="EN-US">, as well as <span style="font-size: 11.0pt;mso-bidi-font-size:10.0pt;font-family:" times="" new="" roman","serif";="" mso-fareast-font-family:calibri;mso-ansi-language:en-us;mso-fareast-language:="" en-us;mso-bidi-language:ar-sa"="" lang="EN-US">in the perfumery, cosmetic and aromatherapy industries all over the world<span style="font-size:11.0pt; mso-bidi-font-size:10.0pt;font-family:" times="" new="" roman","serif";mso-fareast-font-family:="" "times="" roman";mso-ansi-language:en-us;mso-fareast-language:en-us;="" mso-bidi-language:ar-sa"="" lang="EN-US">. P. graveolens has recently been shown to have antioxidant, antibacterial, antifungal activities and acaricidal effects. The valuable therapeutic aspects of P. graveolens are mostly correlated to the existence of volatile constituents, terpenoids and flavonoids. Due to being widespread and the easy collection of this plant and also remarkable biological activities and containing a high amount of essential oil, this plant has become a medicinal plant in pharmacy especially in aromatherapy. This overview presents comprehensive analyzed information on the phytochemical and clinical properties of P. graveolens.</span

    The Effect of Hydro-alcoholic Extract of Leaves of Vitex on the Gestation Indices of Male Rats

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    Background: Phytoestrogens are some plant compounds with estrogenic biological effects which are found in many nutritional sources as soybean, flaxseed, and sesame. Vitex agnus-castus, also called Vitex, owns phytoestrogen properties. Studies have shown that phytoestrogens have different impacts on the gestation process and reproduction indices. Objective: The present study was aimed to investigate the effects of Vitex extract on the gestation indices in the male rat as well as studying its histological properties in the rat testicles. Materials and Methods: The hydro-alcoholic extract of Vitex (in three doses of 165, 265 and 365 mg/kg), vehicle (normal saline) and the hydro-alcoholic powder of soybean (120 mg/kg) were respectively given to understudy, vehicle and positive control groups for 49 days. After weighing the rats in the 1st and 49th days, the blood samples of all groups were taken and tested for estradiol levels, testosterones, FSH and LH.Moreover, such reproductive indices as sperm count, sperm motion, and prostate and testicle weight were studied and samples were collected for histological studies. Results: Prescription of the hydro-alcoholic extract of Vitex (in three doses of 165, 265 and 365 mg/kg) did not change the rat’s weight, significantly (P-value= 0.06). Hormonal studies reduced the progesterone, LH, and FSH compared to the vehicle group, significantly (P-value<0.05). In addition, the amount of estradiol was significantly more than the vehicle group and the most effect was observed at a dose of 365 mg/kg (P-value=0.02). Histological studies showed a reduction in existing spermatozoa in the seminiferous ducts. Conclusions: This study had shown that the Vitex extract had inhibiting effects on the gestation indices in male rat and due to its destructive effects on the testicle tissues, more studies were required
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