Revealing the Key Proteins under Telecommunications’ Tower in Brain Tissue of Rats through Proteomics Approach: Biological effects of ELF/EMF on Brain’s tissue

Introduction: Although there are a lot of interests in telecommunications tower approaches in view of Cancer, limited researches have studied the molecular pathways, which are enriched under ELF/EMF. The aim of this study is investigating the key proteins, affected by by Tower. Materials and Methods: In this study, 30 Rats under wavelength electromagnetic waves (RF900 MHz) were randomly selected. Two-dimensional electrophorese was performed to study proteomics of Rat’s brain. Results: Totally, 26 differentially uttered proteins (DEPs) were categorized by cytoscape network analysis. Conclusion: Some key proteins in view of cancer are regulated under the face of a non-standard (unconventional) radio frequency radiation, which can induce the complement and coagulation cascades pathway. &nbsp

Cellular Effects of Wound Fluid (Seroma) from Tumor Bed on Human Breast Cancer Cell Lines: Seroma in breast cancer cell lines

Introduction: Post-lumpectomy wound fluid (seroma) contains many proteins from tumor bed due to physiologic answer to operation and wound healing process. Some cellular tests had been performed on different types of breast cancer (BC) cell lines and normal cell line while treated with seroma. Materials and Methods: The wound fluid samples were collected from BC patients. The human BC cell lines included MCF-7, MDA-MB-231 as well as normal non-tumorigenic epithelial cell line (MCF-10). Results: Seroma could inhibit various cancer cells proliferation pattern in comparison with the normal cell. Concerning the cell death, aggressive MDA-MB-231 cells were put into the apoptosis process. Besides, seroma could decrease colony count and size and changed the clone morphology from holoclone to paraclone. Regarding the invasion assay, seroma significantly inhibited cell motility. Conclusion: By remaining in tumor bed, seroma can induce inhibitory pattern of proliferation, and change the morphology of cancer cell colony and cell motility, consequently leading to positive impact on patients who suffer from   cancer