1 research outputs found
Ortho C–H Bond Activations in an Atmospheric Microwave Plasma Ion Source
C–H bond ortho-substitution reaction has always
been a significant
and challenging topic in organic chemistry. We proposed a synthesis
method based on microwave plasma torches. High-resolution mass spectrometry
was used to monitor rapid reaction products. 2-Alkylbenzimidazole
can be formed through the reaction of phenylnitrenium ion and nitriles
on a millisecond scale. This reaction can achieve the one-step formation
of benzimidazoles from benzene ring single-substituted compounds without
the addition of external oxidants or catalysts. A similar C–H
bond activation reaction can be accomplished with ketones. Meanwhile,
the microwave plasma reactor was modified, and the resulting 2-methylbenzimidazole
was successfully collected, indicating the device has good application
potential in organic reactions such as C–H bond activation
reaction