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    Additional file 1: Figure S1. of CCR7loPD-1hi CXCR5+ CD4+ T cells are positively correlated with levels of IL-21 in active and transitional cystic echinococcosis patients

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    The schematic of circulating Tfh cells and antibody formation in peripheral blood of CE. Eg can release a large amount of Ag which may active Naive T cells by APC (antigen-present-cell). Naive T cells express Bcl-6 and differentiate into effector T cells. Most Bcl-6 high expression effector T cells develop into Tfh cells to help B cells to produce antibodies in host Eg-infection. Some of Bcl-6 high expression effector T cells move into peripheral blood and develop into circulating Tfh cells, which can produce IL-21. (TIFF 188 kb
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