5,242 research outputs found
Incorporating Intra-Class Variance to Fine-Grained Visual Recognition
Fine-grained visual recognition aims to capture discriminative
characteristics amongst visually similar categories. The state-of-the-art
research work has significantly improved the fine-grained recognition
performance by deep metric learning using triplet network. However, the impact
of intra-category variance on the performance of recognition and robust feature
representation has not been well studied. In this paper, we propose to leverage
intra-class variance in metric learning of triplet network to improve the
performance of fine-grained recognition. Through partitioning training images
within each category into a few groups, we form the triplet samples across
different categories as well as different groups, which is called Group
Sensitive TRiplet Sampling (GS-TRS). Accordingly, the triplet loss function is
strengthened by incorporating intra-class variance with GS-TRS, which may
contribute to the optimization objective of triplet network. Extensive
experiments over benchmark datasets CompCar and VehicleID show that the
proposed GS-TRS has significantly outperformed state-of-the-art approaches in
both classification and retrieval tasks.Comment: 6 pages, 5 figure
Trusted Multi-Scale Classification Framework for Whole Slide Image
Despite remarkable efforts been made, the classification of gigapixels
whole-slide image (WSI) is severely restrained from either the constrained
computing resources for the whole slides, or limited utilizing of the knowledge
from different scales. Moreover, most of the previous attempts lacked of the
ability of uncertainty estimation. Generally, the pathologists often jointly
analyze WSI from the different magnifications. If the pathologists are
uncertain by using single magnification, then they will change the
magnification repeatedly to discover various features of the tissues. Motivated
by the diagnose process of the pathologists, in this paper, we propose a
trusted multi-scale classification framework for the WSI. Leveraging the Vision
Transformer as the backbone for multi branches, our framework can jointly
classification modeling, estimating the uncertainty of each magnification of a
microscope and integrate the evidence from different magnification. Moreover,
to exploit discriminative patches from WSIs and reduce the requirement for
computation resources, we propose a novel patch selection schema using
attention rollout and non-maximum suppression. To empirically investigate the
effectiveness of our approach, empirical experiments are conducted on our WSI
classification tasks, using two benchmark databases. The obtained results
suggest that the trusted framework can significantly improve the WSI
classification performance compared with the state-of-the-art methods
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The interplay between thermodynamics and kinetics in the solid-state synthesis of layered oxides.
In the synthesis of inorganic materials, reactions often yield non-equilibrium kinetic byproducts instead of the thermodynamic equilibrium phase. Understanding the competition between thermodynamics and kinetics is a fundamental step towards the rational synthesis of target materials. Here, we use in situ synchrotron X-ray diffraction to investigate the multistage crystallization pathways of the important two-layer (P2) sodium oxides Na0.67MO2 (M = Co, Mn). We observe a series of fast non-equilibrium phase transformations through metastable three-layer O3, O3' and P3 phases before formation of the equilibrium two-layer P2 polymorph. We present a theoretical framework to rationalize the observed phase progression, demonstrating that even though P2 is the equilibrium phase, compositionally unconstrained reactions between powder precursors favour the formation of non-equilibrium three-layered intermediates. These insights can guide the choice of precursors and parameters employed in the solid-state synthesis of ceramic materials, and constitutes a step forward in unravelling the complex interplay between thermodynamics and kinetics during materials synthesis
Increased fibroblast functionality on CNN2-loaded titania nanotubes
Infection and epithelial downgrowth are major problems associated with maxillofacial percutaneous implants. These complications are mainly due to the improper closure of the implant–skin interface. Therefore, designing a percutaneous implant that better promotes the formation of a stable soft tissue biologic seal around percutaneous sites is highly desirable. Additionally, the fibroblast has been proven to play an important role in the formation of biologic seals. In this study, titania nanotubes were filled with 11.2 kDa C-terminal CCN2 (connective tissue growth factor) fragment, which could exert full CCN2 activity to increase the biological functionality of fibroblasts. This drug delivery system was fabricated on a titanium implant surface. CCN2 was loaded into anodized titania nanotubes using a simplified lyophilization method and the loading efficiency was approximately 80%. Then, the release kinetics of CCN2 from these nanotubes was investigated. Furthermore, the influence of CCN2-loaded titania nanotubes on fibroblast functionality was examined. The results revealed increased fibroblast adhesion at 0.25, 0.5, 1, 2, 4, and 24 hours, increased fibroblast viability over the course of 5 days, as well as enhanced actin cytoskeleton organization on CCN2-loaded titania nanotubes surfaces compared to uncoated, unmodified counterparts. Therefore, the results from this in vitro study demonstrate that CCN2-loaded titania nanotubes have the ability to increase fibroblast functionality and should be further studied as a method of promoting the formation of a stable soft tissue biologic seal around percutaneous sites
Significance of HER2 protein expression and HER2 gene amplification in colorectal adenocarcinomas
BACKGROUND: Human epidermal growth factor receptor 2 (HER2) is an oncogenic driver, and a well-established therapeutic target in breast and gastric cancers. While the role of HER2 as a prognostic biomarker in colorectal adenocarcinomas (CRCs) remains uncertain, its relevance as a therapeutic target has been established. We undertook the present study to evaluate the frequency of HER2 expression in CRC and to correlate it with various clinicopathological variables.
AIM: To correlate HER2 protein expression and
METHODS: About 1195 consecutive surgically resected CRCs were analyzed by immunohistochemical staining (IHC) to assess HER2 protein expression, and 141 selected tumors were further evaluated by fluorescence
RESULTS: HER2 IHC scores of 3+, 2+, 1+, and 0 were seen in 31 (2.6%), 105 (8.8%), 475 (39.7%), and 584 (48.9%) tumors, respectively.
CONCLUSION: HER2 protein levels are correlated with clinical outcomes, and positive HER2 expression as measured by IHC confers a worse prognosis in those patients 65 years old or younger with tubular adenocarcinomas
Poly[bis(μ-2,6-dimethylpyridinium-3,5-dicarboxylato-κ 2 O 3:O 5)copper(II)]
In the title coordination polymer, [Cu(C9H8NO4)2]n, the Cu atom, located on a twofold rotation axis, is four coordinate in a distorted square-planar environment. Each 2,6-dimethylpyridinium-3,5-dicarboxylate anion bridges two Cu atoms, forming a two-dimensional coordination polymer. A three-dimensional supramolecular network is built from N—H⋯O hydrogen bonds involving the pyridinium NH and the carboxyl COO groups
Intermolecular Failure of L-type Ca(2+) Channel and Ryanodine Receptor Signaling in Hypertrophy
Pressure overload–induced hypertrophy is a key step leading to heart failure. The Ca(2+)-induced Ca(2+) release (CICR) process that governs cardiac contractility is defective in hypertrophy/heart failure, but the molecular mechanisms remain elusive. To examine the intermolecular aspects of CICR during hypertrophy, we utilized loose-patch confocal imaging to visualize the signaling between a single L-type Ca(2+) channel (LCC) and ryanodine receptors (RyRs) in aortic stenosis rat models of compensated (CHT) and decompensated (DHT) hypertrophy. We found that the LCC-RyR intermolecular coupling showed a 49% prolongation in coupling latency, a 47% decrease in chance of hit, and a 72% increase in chance of miss in DHT, demonstrating a state of “intermolecular failure.” Unexpectedly, these modifications also occurred robustly in CHT due at least partially to decreased expression of junctophilin, indicating that intermolecular failure occurs prior to cellular manifestations. As a result, cell-wide Ca(2+) release, visualized as “Ca(2+) spikes,” became desynchronized, which contrasted sharply with unaltered spike integrals and whole-cell Ca(2+) transients in CHT. These data suggested that, within a certain limit, termed the “stability margin,” mild intermolecular failure does not damage the cellular integrity of excitation-contraction coupling. Only when the modification steps beyond the stability margin does global failure occur. The discovery of “hidden” intermolecular failure in CHT has important clinical implications
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