214 research outputs found
Biodegradation behavior of micro-arc oxidation coating on magnesium alloy-from a protein perspective
Protein exerts a critical influence on the degradation behavior of absorbable magnesium (Mg)-based implants. However, the interaction mechanism between protein and a micro-arc oxidation (MAO) coating on Mg alloys remains unclear. Hereby, a MAO coating was fabricated on AZ31 Mg alloy. And its degradation behavior in phosphate buffer saline (PBS) containing bovine serum albumin (BSA) was investigated and compared with that of the uncoated alloy. Surface morphologies and chemical compositions were studied using Field-emission scanning electron microscope (FE-SEM), Fourier transform infrared spectrophotometer (FT-IR) and X-ray diffraction (XRD). The degradation behavior of the bare Mg alloy and its MAO coating was studied through electrochemical and hydrogen evolution tests. Cytotoxicity assay was applied to evaluate the biocompatibility of Mg alloy substrate and MAO coating. Results indicated that the presence of BSA decreased the degradation rate of Mg alloy substrate because BSA (RCH(NH2)COO‾) molecules combined with Mg2+ ions to form (RCH(NH2)COO)2Mg and thus inhibited the dissolution of Mg(OH)2 by impeding the attack of Cl‾ ions. In the case of MAO coated Mg alloy, the adsorption of BSA on MAO coating and the formation of (RCH(NH2)COO)2Mg exhibited a synergistic effect and enhanced the corrosion resistance of the coated alloy significantly. Furthermore, cell bioactive assay suggested that the MAO coating had good viability for MG63 cells due to its high surface area
The Flare and Warp of the Young Stellar Disk traced with LAMOST DR5 OB-type stars
We present analysis of the spatial density structure for the outer disk from
814 \,kpc with the LAMOST DR5 13534 OB-type stars and observe similar
flaring on north and south sides of the disk implying that the flaring
structure is symmetrical about the Galactic plane, for which the scale height
at different Galactocentric distance is from 0.14 to 0.5 \,kpc. By using the
average slope to characterize the flaring strength we find that the thickness
of the OB stellar disk is similar but flaring is slightly stronger compared to
the thin disk as traced by red giant branch stars, possibly implying that
secular evolution is not the main contributor to the flaring but perturbation
scenarios such as interactions with passing dwarf galaxies should be more
possible. When comparing the scale height of OB stellar disk of the north and
south sides with the gas disk, the former one is slightly thicker than the
later one by 33 and 9 \,pc, meaning that one could tentatively use
young OB-type stars to trace the gas properties. Meanwhile, we unravel that the
radial scale length of the young OB stellar disk is 1.17 0.05 \,kpc,
which is shorter than that of the gas disk, confirming that the gas disk is
more extended than stellar disk. What is more, by considering the mid-plane
displacements () in our density model we find that almost all of
are within 100 \,pc with the increasing trend as Galactocentric distance
increases.Comment: 14 pages and 8 figures, Accepted by APJ for publicatio
Therapeutic effect of Rho kinase inhibitor FSD-C10 in a mouse model of Alzheimer\u27s disease.
Fasudil, a Rho kinase (ROCK) inhibitor, effectively inhibits disease severity in a mouse model of Alzheimer\u27s disease (AD). However, given its significant limitations, including a relatively narrow safety window and poor oral bioavailability, Fasudil is not suitable for long-term use. Thus, screening for ROCK inhibitor(s) that are more efficient, safer, can be used orally and suitable for long-term use in the treatment of neurodegenerative disorders is required. The main purpose of the present study is to explore whether FSD-C10, a novel ROCK inhibitor, has therapeutic potential in amyloid precursor protein/presenilin-1 transgenic (APP/PS1 Tg) mice, and to determine possible mechanisms of its action. The results showed that FSD-C10 effectively improved learning and memory impairment, accompanied by reduced expression of amyloid-β1-42 (Aβ 1-42 ), Tau protein phosphorylation (P-tau) and β-site APP-cleaving enzyme in the hippocampus and cortex area of brain. In addition, FSD-C10 administration boosted the expression of synapse-associated proteins, such as postynaptic density protein 95, synaptophsin, α-amino 3-hydroxy-5-methyl-4-isoxa-zolep-propionate receptor and neurotrophic factors, e,g., brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor. Taken together, our results demonstrate that FSD-C10 has therapeutic potential in the AD mouse model, possibly through inhibiting the formation of Aβ 1-42 and P-tau, and promoting the generation of synapse-associated proteins and neurotrophic factors
Strong terahertz radiation from a liquid-water line
Terahertz radiation generation from liquid water has long been considered impossible due to strong absorption. A few very recent works reported terahertz generation from water, but the mechanism is not clear and the efficiency demands to be enhanced. We show experimentally that strong single-cycle terahertz radiation with field strength of 0.2MVcm-1 is generated from a water line (or column) of approximately 200μm in diameter irradiated by a mJ femtosecond laser beam. This strength is 100-fold higher than that produced from air using single-color pumping. We attribute the mechanism to the laser-ponderomotive-force-induced current with the symmetry broken around the water-column interface. This mechanism can explain our following observations: the radiation can be generated only when the laser propagation axis deviates from the column center; the deviation determines its field strength and polarity; it is always p polarized no matter whether the laser is p or s polarized. This study provides a simple and efficient scheme of table-top terahertz sources based on liquid water
An Updated Search of Steady TeV Ray Point Sources in Northern Hemisphere Using the Tibet Air Shower Array
Using the data taken from Tibet II High Density (HD) Array (1997
February-1999 September) and Tibet-III array (1999 November-2005 November), our
previous northern sky survey for TeV ray point sources has now been
updated by a factor of 2.8 improved statistics. From to
in declination (Dec) range, no new TeV ray point
sources with sufficiently high significance were identified while the
well-known Crab Nebula and Mrk421 remain to be the brightest TeV ray
sources within the field of view of the Tibet air shower array. Based on the
currently available data and at the 90% confidence level (C.L.), the flux upper
limits for different power law index assumption are re-derived, which are
approximately improved by 1.7 times as compared with our previous reported
limits.Comment: This paper has been accepted by hepn
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