TRANSDERMIC TRANSPORT BY PORTABLE DEVICES: ANOTHER WAY TO APPLY COSMETICS

ABSTRACT: The skin is an important route of drug application. The outermost layer of skin, the stratum cornea is the first protective portion that hinders the permeability of substances. Physical methods such as ultrasonic peeling, ionization and electroporation can facilitate the entry of substance in the skin. The aim of the study was observe the ultrasonic peeling, the ionization and electroporation effects associated with Nano Gold fluid and Anti-winkle Serum in the skin. METHODS: Six Wistar animals were used and divided randomly into 3 groups of 2 animals each (a control group, a treated group with ultrasonic peeling plus Nano Gold fluid and another group treated with Dermoroller plus Anti-wrinkle Serum). The treatment lasted 10 days consecutive. RESULTS: The Histological analyzes showed a reduced in the cornea stratum and an increase of the epidermis in the group treated with ultrasonic peeling plus ionization and Nano Gold fluid. CONCLUSION: Furthermore, it was observed an increase in the fibroblasts with neoformation of collagen in the treated group with the Dermaroller plus serum anti-wrinkle