92 research outputs found
The supergravity dual of 3d supersymmetric gauge theories with unquenched flavors
We obtain the supergravity dual of N=1 supersymmetric gauge theory in 2+1
dimensions with a large number of unquenched massless flavors. The geometries
found are obtained by solving the equations of motion of supergravity coupled
to a suitable continuous distribution of flavor branes. The background obtained
preserves two supersymmetries. We find that when N_c\ge 2N_f the behavior of
the solutions is compatible with having an asymptotically free dual gauge
theory with dynamical quarks. On the contrary, when N_c<2N_f the theory
develops a Landau pole in the UV. We also find a new family of (unflavored)
backgrounds generated by D5-branes that wrap a three-cycle of a cone with G_2
holonomy.Comment: 56 pages, 11 figures; v2: references adde
Multipotent adult progenitor cells sustain function of ischemic limbs in mice
Despite progress in cardiovascular research, a cure for peripheral vascular disease has not been found. We compared
the vascularization and tissue regeneration potential of murine and human undifferentiated multipotent
adult progenitor cells (mMAPC-U and hMAPC-U), murine MAPC-derived vascular progenitors (mMAPC-VP),
and unselected murine BM cells (mBMCs) in mice with moderate limb ischemia, reminiscent of intermittent
claudication in human patients. mMAPC-U durably restored blood flow and muscle function and stimulated
muscle regeneration, by direct and trophic contribution to vascular and skeletal muscle growth. This was in
contrast to mBMCs and mMAPC-VP, which did not affect muscle regeneration and provided only limited and
transient improvement. Moreover, mBMCs participated in a sustained inflammatory response in the lower
limb, associated with progressive deterioration in muscle function. Importantly, mMAPC-U and hMAPC-U also
remedied vascular and muscular deficiency in severe limb ischemia, representative of critical limb ischemia in
humans. Thus, unlike BMCs or vascular-committed progenitors, undifferentiated multipotent adult progenitor
cells offer the potential to durably repair ischemic damage in peripheral vascular disease patients
Molecular epidemiology and extended-spectrum β-lactamases production of Klebsiella pneumoniae isolated from three dairy herds
Reaction of sweet orange cultivars expressing the attacin A gene to 'Candidatus Liberibacter asiaticus' infection
Enhancing global vaccine pharmacovigilance: Proof-of-concept study on aseptic meningitis and immune thrombocytopenic purpura following measles-mumps containing vaccination
New vaccines designed to prevent diseases endemic in low and middle-income countries (LMICs) are now being introduced without prior record of utilization in countries with robust pharmacovigilance systems. To address this deficit, our objective was to demonstrate feasibility of an international hospital-based network for the assessment of potential epidemiological associations between serious and rare adverse events and vaccines in any setting. This was done through a proof-of-concept evaluation of the risk of immune thrombocytopenic purpura (ITP) and aseptic meningitis (AM) following administration of the first dose of measles-mumps-containing vaccines using the self-controlled risk interval method in the primary analysis. The World Health Organization (WHO) selected 26 sentinel sites (49 hospitals) distributed in 16 countries of the six WHO regions. Incidence rate ratios (IRR) of 5.0 (95% CI: 2.5-9.7) for ITP following first dose of measles-containing vaccinations, and of 10.9 (95% CI: 4.2-27.8) for AM following mumps-containing vaccinations were found. The strain-specific analyses showed significantly elevated ITP risk for measles vaccines containing Schwarz (IRR: 20.7; 95% CI: 2.7-157.6), Edmonston-Zagreb (IRR: 11.1; 95% CI: 1.4-90.3), and Enders'Edmonston (IRR: 8.5; 95% CI: 1.9-38.1) strains. A significantly elevated AM risk for vaccines containing the Leningrad-Zagreb mumps strain (IRR: 10.8; 95% CI: 1.3-87.4) was also found. This proof-of-concept study has shown, for the first time, that an international hospital-based network for the investigation of rare vaccine adverse events, using common standardized procedures and with high participation of LMICs, is feasible, can produce reliable results, and has the potential to characterize differences in risk between vaccine strains. The completion of this network by adding large reference hospitals, particularly from tropical countries, and the systematic WHO-led implementation of this approach, should permit the rapid post-marketing evaluation of safety signals for serious and rare adverse events for new and existing vaccines in all settings, including LMICs
Indicadores do ambiente ruminal e suas relações com a composição do leite e células somáticas em diferentes períodos da primeira fase da lactação em vacas de alta produção
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