Les Italiens et l’image du Maroc dans l’œuvre narrative de Younis Tawfik

L’œuvre narrative de Younis Tawfik, qui comporte deux romans, La straniera et La città di Iram, parus en 1999 et 2002 chez l’éditeur milanais Bompiani, se prête particulièrement bien au thème de la différence. La différence y prend d’innombrables formes : elle est linguistique chez cet auteur d’origine irakienne, installé depuis quelques décennies en Italie et qui écrit en italien ; elle est culturelle et religieuse, Tawfik étant de culture arabo-musulmane ; elle est aussi sexuelle puisque ce..

A INFÂNCIA E A FORMAÇÃO. O PRIMEIRO EXÍLIO NO BRASIL (1876-1919)

Tradução de Carlo Romani e Gabriela Ribeir

2017 Hospital Profile: Boston Children's Hospital

Massachusetts Acute Hospital Profile

Vaccination with human anti-trastuzumab anti-idiotype scFv reverses HER2 immunological tolerance and induces tumor immunity in MMTV.f.huHER2(Fo5) mice

International audienceINTRODUCTION: Novel adjuvant therapies are needed to prevent metastatic relapses in HER2-expressing breast cancer. Here, we tested whether trastuzumab-selected single-chain Fv (scFv) could be used to develop an anti-idiotype-based vaccine to inhibit growth of HER2-positive tumor cells in vitro and in vivo through induction of long-lasting HER-specific immunity. METHODS: BALB/c mice were immunized with anti-trastuzumab anti-idiotype (anti-Id) scFv (scFv40 and scFv69), which mimic human HER2. Their sera were assessed for the presence of HER2-specific Ab1' antibodies and for their ability to reduce viability of SK-OV-3 cells, a HER2-positive cancer cell line, in nude mice. MMTV.f.huHER2(Fo5) transgenic mice were immunized with scFv40 and scFv69 and, then, growth inhibition of spontaneous HER2-positive mammary tumors, humoral response, antibody isotype as well as splenocyte secretion of IL2 and IFN-γ were evaluated. RESULTS: Adoptively-transferred sera from BALB/c mice immunized with scFv40 and scFv69 contain anti-HER2 Ab1' antibodies that can efficiently inhibit growth of SK-OV-3 cell tumors in nude mice. Similarly, prophylactic vaccination with anti-Id scFv69 fully protects virgin or primiparous FVB-MMTV.f.huHER2(Fo5) females from developing spontaneous mammary tumors. Moreover, such vaccination elicits an anti-HER2 Ab1' immune response together with a scFv69-specific Th1 response with IL2 and IFN-γ cytokine secretion. CONCLUSIONS: Anti-trastuzumab anti-Id scFv69, used as a therapeutic or prophylactic vaccine, protects mice from developing HER2-positive mammary tumors by inducing both anti-HER2 Ab1' antibody production and an anti-HER2 Th2-dependent immune response. These results suggest that scFv69 could be used as an anti-Id-based vaccine for adjuvant therapy of patients with HER2-positive tumors to reverse immunological tolerance to HER2

Makhno et la révolution ukrainienne, 1917-1921

TraductionsInternational audienceOuvrage d'Ettore Cinnella traduit de l'italie

L'émigré ce héros: Les étapes du parcours migratoire dans les récits d'émigration

International audienc

Giovanni Pascoli rend hommage à Francisco Ferrer

Documents sans référence de publicatio

De l'usage de l'histoire par les chercheurs en littérature et civilisation : le cas des phénomènes migratoires en Italie (XIXe et XXe siècles)

National audienc

Poésie d'un rebelle: poète, anarchiste, émigré, 1876-1953

Sujet : Gigi DamianiNational audienc

Les Croquignards, une "Bande à Bonnot des montagnes" ?

Billet de blog disponible en ligne à l'adresse : http://atelierdecreationlibertaire.com/blogs/anarchistes-italiens/2011/02/02/les-croquignard-une-%C2%ABbande-a-bonnot-des-montagnes%C2%BB/Documents sans référence de publicatio