The Linkage Between Fitness, Nutrition and Mind for our Well-being, Abundance and Health

The purpose of this study was to examine the linkage between Fitness, Nutrition and Mind for our Well-being, Abundance and Health. This study aimed to inspire each individual to seek health the way that suits him, while taking into consideration "all area of life" and the strong rapport between three components that determent our health: fitness- "work-out", nutrition-"eating smart" and mind- "work-in" mentally, emotionally and spiritually. The work, a product of more than ten years of practicing the GymindTM method (combining Gymnastics and Mind) learned how the right "usage" of all three components is the key for best physical and mental health of the self, according to his or her goals in life. Researches and recent fitness-nutrition-mind studies formed the grounds of this work, along with studies of the subconscious mind such as NLP, EFT, Time-line-therapy, hypnotherapy and Theta-Healing, in order to look over the body-mind connection for therapy and personal growth. The field of "discourse analysis" (mainly a la Perelman's new rhetoric) served at times as a tool to present a thesis and ease the connection of all components of this interdisciplinary study. Personal stories, presented in italic and painted in grey reveal the path of 17 individuals, (not all present in this article) varied in age (adults and children), gender and goals in life, consistently emerged throughout the study. They all agreed to reveal their own fitness-nutrition-mind experience (they have been embracing over the years as my patients), in order to convey a strong message, tips and guidelines about changing bad habits, embrace an active life-style, making healthier nutritional choices, improving self-image, getting stronger physically and mentally, heal themselves and find spiritual growth. They all mainly provide an inspiration for us to find our own finest path, know ourselves better and mainly take charge over our life and take action towards Well-being, Abundance and Health

The Linkage Between Fitness, Nutrition and Mind for our Well-being, Abundance and Health

The purpose of this study was to examine the linkage between Fitness, Nutrition and Mind for our Well-being, Abundance and Health. This study aimed to inspire each individual to seek health the way that suits him, while taking into consideration "all area of life" and the strong rapport between three components that determent our health: fitness- "work-out", nutrition-"eating smart" and mind- "work-in" mentally, emotionally and spiritually. The work, a product of more than ten years of practicing the GymindTM method (combining Gymnastics and Mind) learned how the right "usage" of all three components is the key for best physical and mental health of the self, according to his or her goals in life. Researches and recent fitness-nutrition-mind studies formed the grounds of this work, along with studies of the subconscious mind such as NLP, EFT, Time-line-therapy, hypnotherapy and Theta-Healing, in order to look over the body-mind connection for therapy and personal growth. The field of "discourse analysis" (mainly a la Perelman's new rhetoric) served at times as a tool to present a thesis and ease the connection of all components of this interdisciplinary study. Personal stories, presented in italic and painted in grey reveal the path of 17 individuals, (not all present in this article) varied in age (adults and children), gender and goals in life, consistently emerged throughout the study. They all agreed to reveal their own fitness-nutrition-mind experience (they have been embracing over the years as my patients), in order to convey a strong message, tips and guidelines about changing bad habits, embrace an active life-style, making healthier nutritional choices, improving self-image, getting stronger physically and mentally, heal themselves and find spiritual growth. They all mainly provide an inspiration for us to find our own finest path, know ourselves better and mainly take charge over our life and take action towards Well-being, Abundance and Health

Tau and Caspase 3 as Targets for Neuroprotection

The peptide drug candidate NAP (davunetide) has demonstrated protective effects in various in vivo and in vitro models of neurodegeneration. NAP was shown to reduce tau hyperphosphorylation as well as to prevent caspase-3 activation and cytochrome-3 release from mitochondria, both characteristic of apoptotic cell death. Recent studies suggest that caspases may play a role in tau pathology. The purpose of this study was to evaluate the effect of NAP on tau hyperphosphorylation and caspase activity in the same biological system. Our experimental setup used primary neuronal cultures subjected to oxygen-glucose deprivation (OGD), with and without NAP or caspase inhibitor. Cell viability was assessed by measuring mitochondrial activity (MTS assay), and immunoblots were used for analyzing protein level. It was shown that apoptosis was responsible for all cell death occurring following ischemia, and NAP treatment showed a concentration-dependent protection from cell death. Ischemia caused an increase in the levels of active caspase-3 and hyperphosphorylated tau, both of which were prevented by either NAP or caspase-inhibitor treatment. Our data suggest that, in this model system, caspase activation may be an upstream event to tau hyperphosphorylation, although additional studies will be required to fully elucidate the cascade of events

The motivation and inhibition of breaking the rules:Personal values structures predict unethicality

© 2015 Elsevier Inc. We theorized and tested the relationship of personal value systems with unethical attitudes and behavior. Results from three studies using 16 diverse multi-national samples (N= 107,087) demonstrated the complexity of motivations underlying unethicality. Across contexts and cultures, for attitudes (Study 1 meta-analysis) and behaviors in the lab (Study 2) and in real-life (Study 3), we consistently found that the values theory circumplex structure predicted the inhibition and motivation of unethicality. Unethicality was positively associated with self-enhancement values and negatively associated with self-transcendence and conservation values. However, self-transcendence and conservation values were associated with the inhibition of different types of unethicality. The relationship of openness-to-change values with unethicality was generally positive but the effect size varied depending on context.Link_to_subscribed_fulltex

Sex determination, longevity, and the birth and death of reptilian species

Vertebrate sex-determining mechanisms (SDMs) are triggered by the genotype (GSD), by temperature (TSD), or occasionally, by both. The causes and consequences of SDM diversity remain enigmatic. Theory predicts SDM effects on species diversification, and life-span effects on SDM evolutionary turnover. Yet, evidence is conflicting in clades with labile SDMs, such as reptiles. Here, we investigate whether SDM is associated with diversification in turtles and lizards, and whether alterative factors, such as lifespan\u27s effect on transition rates, could explain the relative prevalence of SDMs in turtles and lizards (including and excluding snakes). We assembled a comprehensive dataset of SDM states for squamates and turtles and leveraged large phylogenies for these two groups. We found no evidence that SDMs affect turtle, squamate, or lizard diversification. However, SDM transition rates differ between groups. In lizards TSD-to-GSD surpass GSD-to-TSD transitions, explaining the predominance of GSD lizards in nature. SDM transitions are fewer in turtles and the rates are similar to each other (TSD-to-GSD equals GSD-to-TSD), which, coupled with TSD ancestry, could explain TSD\u27s predominance in turtles. These contrasting patterns can be explained by differences in life history. Namely, our data support the notion that in general, shorter lizard lifespan renders TSD detrimental favoring GSD evolution in squamates, whereas turtle longevity permits TSD retention. Thus, based on the macro-evolutionary evidence we uncovered, we hypothesize that turtles and lizards followed different evolutionary trajectories with respect to SDM, likely mediated by differences in lifespan. Combined, our findings revealed a complex evolutionary interplay between SDMs and life histories that warrants further research that should make use of expanded datasets on unexamined taxa to enable more conclusive analyses

6′′‐Thioether Tobramycin Analogues: Towards Selective Targeting of Bacterial Membranes

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/91322/1/ange_201200761_sm_miscellaneous_information.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/91322/2/5750_ftp.pd

Personality Traits and Personal Values:A Meta-Analysis

Personality traits and personal values are important psychological characteristics, serving as important predictors of many outcomes. Yet, they are frequently studied separately, leaving the field with a limited understanding of their relationships. We review existing perspectives regarding the nature of the relationships between traits and values and provide a conceptual underpinning for understanding the strength of these relationships. Using 60 studies, we present a meta-analysis of the relationships between the Five-Factor Model (FFM) of personality traits and the Schwartz values, and demonstrate consistent and theoretically meaningful relationships. However, these relationships were not generally large, demonstrating that traits and values are distinct constructs. We find support for our premise that more cognitively based traits are more strongly related to values and more emotionally based traits are less strongly related to values. Findings also suggest that controlling for personal scale-use tendencies in values is advisable

The geography of snake reproductive mode: a global analysis of the evolution of snake viviparity

Aim : Although most reptiles are oviparous, viviparity is a commonmode of reproduction in squamates and has evolved multiple times in different lineages.We test two prevailing hypotheses regarding the biogeography of reptile reproductive modes to evaluate the selective forces driving the evolution of viviparity in snakes. The cold climate hypothesis posits that viviparity is selected for in cold climates, whereas the climatic predictability hypothesis predicts that viviparity is advantageous in seasonal climates. Methods : We collated detailed distribution maps and reproductive mode data for 2663 species of the world’s terrestrial alethinophidian snakes.We studied the relationship between snake reproductive mode and environmental predictors. We applied both an ecological and an evolutionary approach to study snake reproductive mode by performing the analyses at the assemblage level and species level, respectively. We analysed our data at the global and continental scales to learn whether tendencies to viviparity are similar world-wide. Results : We found strong support for the cold climate hypothesis and the assumption that viviparity is an adaptation to cold environments. There was little support for the climatic predictability hypothesis. Nonetheless, viviparous species are not restricted to cold environments. Main conclusions : We conclude that viviparity is adaptive in cold climates, but not necessarily in unpredictable/seasonal climates. Current distributions may not reflect the climate at the time and place of speciation.We suspect many viviparous snakes inhabiting warm climates are members of lineages that originated in colder regions, and their occurrence in maladaptive environments is a result of phylogenetic conservatism

Resistance to checkpoint blockade therapy through inactivation of antigen presentation

Treatment with immune checkpoint blockade (CPB) therapies often leads to prolonged responses in patients with metastatic melanoma, but the common mechanisms of primary and acquired resistance to these agents remain incompletely characterized and have yet to be validated in large cohorts. By analyzing longitudinal tumor biopsies from 17 metastatic melanoma patients treated with CPB therapies, we observed point mutations, deletions or loss of heterozygosity (LOH) in beta-2-microglobulin (B2M), an essential component of MHC class I antigen presentation, in 29.4% of patients with progressing disease. In two independent cohorts of melanoma patients treated with anti-CTLA4 and anti-PD1, respectively, we find that B2M LOH is enriched threefold in non-responders (~30%) compared to responders (~10%) and associated with poorer overall survival. Loss of both copies of B2M is found only in non-responders. B2M loss is likely a common mechanism of resistance to therapies targeting CTLA4 or PD1

Development of the Mental Number Line Representation of Numbers 0–10 and Its Relationship to Mental Arithmetic

The internal representation of numbers on the mental number line (MNL) was demonstrated by performing the computerized version of the number-to-position (CNP) task on a touchscreen while restricting response time. We found that the estimation pattern is best fit by a sigmoid function, further denoted as the “sigmoidal model”. Two developmental leaps occurring during elementary school were recognized: (1) the division of the number line into two segments and (2) consistent use of different anchor points on the number line—the left endpoint in first grade, the right endpoint in second grade, and finally the midpoint in third grade. Additionally, when examining the differences between the breakpoints, we found that first graders demonstrated a breakpoint close to 6, which linearly decreased over the years until stabilizing close to 5. The relation between the ability to place individual numbers on a number line and performance of mental arithmetic showed that the consistent use of anchor points correlated significantly with faster responses in mental arithmetic