2 research outputs found

    JOP762072_Supplementary_Material – Supplemental material for Gemfibrozil has antidepressant effects in mice: Involvement of the hippocampal brain-derived neurotrophic factor system

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    <p>Supplemental material, JOP762072_Supplementary_Material for Gemfibrozil has antidepressant effects in mice: Involvement of the hippocampal brain-derived neurotrophic factor system by Yu-Fei Ni, Hao Wang, Qiu-Yan Gu, Fei-Ying Wang, Ying-Jie Wang, Jin-Liang Wang and Bo Jiang in Journal of Psychopharmacology</p

    An Improved and Enantioselective Preparation of the Telaprevir Bicyclic [3.3.0] Proline Intermediate and Reuse of Unwanted Enantiomer

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    An improved, concise, and efficient preparation of the telaprevir bicyclic [3.3.0] proline intermediate is presented. The key steps, control points, and the whole process are optimized. The synthesis of racemic intermediate was accomplished in five steps in above 56% overall yield up to 100 g scale with only some simple separations and treatments in the whole process. The new and crucial chiral resolution of the proline intermediate was systematically studied, and the target chiral intermediate was obtained in acceptable yield (30%) and excellent ee value (>99% ee) by a simple washing. The cost of the target chiral intermediate and wastes of the whole process were at least doubly reduced after the effective reuse of the unwanted chiral amino acid by successful decarboxylation
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