50 Tips for Traveling Responsibly

Travel is one of the great things in life. Nothing beats the thrill of seeing new things, exploring new cultures or experiencing things you just can\u27t do at home. Despite the benefits of travel, more people are becoming concerned that our travel is having negative impacts on the people and places we visit. We worry that we will love our special places to death. In fact, recent research conducted by Booking.com shows that 83% of global travelers think sustainable travel is vital and of the more than 29,000 travelers surveyed across 30 countries, 72% believe that we need to act now to save the planet for future generations. We want to do better-to travel in ways that respect culture and protects the environment. It was found that 61% of global travelers stated the coronavirus pandemic influenced them to want to travel more sustainably. So where to start? One of the big challenges is knowing what you can do to make your travel more responsible. In this report we share 50 practical tips for traveling more responsibly

A systematic literature review on the responsible travel behavior of tourists in destination tourism

Responsible travel can be referenced in a variety of ways in academic literature due to similar terms and synonyms. Responsible travel does not have a formal definition although, it is being researched in a wide range of contexts. This study is a systematic literature review on the responsible travel behavior of tourisms in destination tourism. This study aims to identify what literature exists currently that investigates or aims to promote responsible travel behavior of tourists at a destination. This study is also interested in identifying if there is any literature that measures the responsible travel behavior of tourists. This will specifically address whether scales, measurements, tests, assessments, or instruments have been developed to measure responsible travel behavior. This study will be one of the first studies to consolidate the vast information regarding responsible travel, while recognizing that responsible travel can be referenced in a variety of ways. This study may also identify current gaps in responsible travel research and identify whether there is a lack of instruments to measure responsible travel behavior while traveling to a destination

A Qualitative Study on the Perceptions of Soft Commitment Devices in Tourism

The negative impacts of mass tourism is attracting attention and tourism destinations are looking for ways to promote responsible travel behaviors among tourists. Commitment devices are being used to promote such behaviors. There are two types of commitment devices: soft and hard. studies have explored how soft commitment devices are being perceived by tourists. This study will explore the perceptions of three soft commitment devices being implemented in the tourist experience through the tourists’ perception. This study will provide key insights into the positive and/or negative attitudes toward the commitment devices being used to increase sustainable travel behaviors among tourists. Data will be collected through semi-structured interviews. The results of this study will reveal how tourists interpret the use of soft commitment devices and their perceived impact of such tools. This paper provides new insights about the practicalities of soft commitment devices used to promote sustainable travel behavior

Haemophagocytic lymphohistiocytosis occurred during induction chemotherapy in an acute monocytic leukemia patient with FLT3-ITD and DNMT3A mutations

Abstract Background Haemophagocytic lymphohistiocytosis (HLH) is considered to be a large challenge for clinicians due to the variable overlaps of symptoms with other severe diseases and a high rate of mortality. Prompt diagnosis and treatment are crucial to avoid a fatal outcome. However, very limited reports have focused on HLH during chemotherapy (Ch-HLH) due to a low incidence and insufficient knowledge. Case presentation A 22-year-old male was diagnosed with acute monocytic leukemia with FLT3-ITD and DNMT3A mutations and pulmonary infection. He received IA regimen (Idarubicin, 8 mg/m2/d for 3 days and cytarabine, 100 mg/m2/d for 7 days) chemotherapy, anti-infection drugs and blood components transfusions. During the stage of bone marrow suppression, he presented with a fever, cytopenia (WBC, 0.43 × 109/L; Hb, 73 g/L and PLT, 1 × 109/L), refractory coagulation dysfunction (APTT, 104.0 s; PT, 30.5 s and Fbg, 0.87 g/L), splenomegaly (3 cm below the costal margin), hyperferritinemia (SF > 3000 μg/L), increased soluble interleukin-II receptors (sIL-2R > 7500 u/mL) and haemophagocytosis in the bone marrow and was diagnosed with HLH. After he was treated with methylprednisolone at 500 mg/d for 3 days, 120 mg/d for 3 days and 80 mg/d for 3 days, followed by a gradually reduced dose combined with powerful anti-infection drugs, his symptoms subsided and his abnormal parameters recovered to normal levels. Conclusion Patients with HLH in acute leukemia have a high rate of mortality. This case report provides helpful clinical experiences relative to the recognition and treatment of Ch-HLH for clinicians

Characterization of Saccharomyces bayanus CN1 for Fermenting Partially Dehydrated Grapes Grown in Cool Climate Winemaking Regions

This project aims to characterize and define an autochthonous yeast, Saccharomyces bayanus CN1, for wine production from partially dehydrated grapes. The yeast was identified via PCR and Basic Local Alignment Search Tool (BLAST) analysis as Saccharomyces bayanus, and then subsequently used in fermentations using partially dehydrated or control grapes. Wine grapes were dried to 28.0°Brix from the control grapes at a regular harvest of 23.0°Brix. Both the partially dehydrated and control grapes were then vinified with each of two yeast strains, S. bayanus CN1 and S. cerevisiae EC1118, which is a common yeast used for making wine from partially dehydrated grapes. Chemical analysis gas chromatography-flame ionization detector (GC-FID) and enzymatic) of wines at each starting sugar level showed that CN1 produced comparable ethanol levels to EC1118, while producing higher levels of glycerol, but lower levels of oxidative compounds (acetic acid, ethyl acetate, and acetaldehyde) compared to EC1118. Yeast choice impacted the wine hue; the degree of red pigment coloration and total red pigment concentration differed between yeasts. A sensory triangle test (n = 40) showed that wines made from different starting sugar concentrations and yeast strains both differed significantly. This newly identified S. bayanus strain appears to be well-suited for this style of wine production from partially dehydrated grapes by reducing the oxidative compounds in the wine, with potential commercial application for cool climate wine regions

Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness

Abstract Cancer cell receives extracellular signal inputs to obtain a stem-like status, yet how tumor microenvironmental (TME) neural signals steer cancer stemness to establish the hierarchical tumor architectures remains elusive. Here, a pan-cancer transcriptomic screening for 10852 samples of 33 TCGA cancer types reveals that cAMP-responsive element (CRE) transcription factors are convergent activators for cancer stemness. Deconvolution of transcriptomic profiles, specification of neural markers and illustration of norepinephrine dynamics uncover a bond between TME neural signals and cancer-cell CRE activity. Specifically, neural signal norepinephrine potentiates the stemness of proximal cancer cells by activating cAMP-CRE axis, where ATF1 serves as a conserved hub. Upon activation by norepinephrine, ATF1 potentiates cancer stemness by coordinated trans-activation of both nuclear pluripotency factors MYC/NANOG and mitochondrial biogenesis regulators NRF1/TFAM, thereby orchestrating nuclear reprograming and mitochondrial rejuvenating. Accordingly, single-cell transcriptomes confirm the coordinated activation of nuclear pluripotency with mitochondrial biogenesis in cancer stem-like cells. These findings elucidate that cancer cell acquires stemness via a norepinephrine-ATF1 driven nucleus-mitochondria collaborated program, suggesting a spatialized stemness acquisition by hijacking microenvironmental neural signals