1,534 research outputs found
An experiment to detect gut monopoles
Recent advances in the development of Grand Unification Theories have led to several interesting predictions. One of these states that Grand Unification Monopoles (GUMs) exist as solutions in may nonabelian gauge theories. Another consequence of Unification is the possibility of baryon decay. The efficiency of the water tank detector in registering a Rubakov type decay will vary with both the interaction length and the GUM's velocity, expressed in terms of beta ( 0.01). The efficiency decreases at large values of because of the limited resolving time of the detector (approx. 50 ns). At lower values of Beta the time between interactions is such that the criterion of 4 events in 2 mu s can no longer be satisfied. The Rubakov experiment has now been in operation for almost 2 years with an estimated live time of 80%. During this time no candidate events have been observed leading to an estimated upper limit on the flux of 7.82 x 0.00001 m(-2) d(-1) Sr(-1). The ionization loss detection system has only recently come on line and as yet no results are available from this experiment
Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit NF-κB activity and synergise with bortezomib and ibrutinib in hematological cancers
Chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) are incurable hematological malignancies that are pathologically linked with aberrant NF-κB activation. In this study, we identified a group of novel C8-linked benzofused Pyrrolo[2,1-c][1,4]benzodiazepines (PBD) monomeric hybrids capable of sequence-selective inhibition of NF-κB with low nanomolar LD50 values in CLL (n=46) and MM cell lines (n=5). The lead compound, DC-1-192, significantly inhibited NF-κB DNA binding after just 4h exposure and demonstrating inhibitory effects on both canonical and non-canonical NF-κB subunits. In primary CLL cells, sensitivity to DC-1-192 was inversely correlated with RelA subunit expression (r2=0.2) and samples with BIRC3 or NOTCH1 mutations showed increased sensitivity (P=0.001). RNA-sequencing and gene set enrichment analysis confirmed the over-representation of NF-κB regulated genes in the down-regulated gene list. Furthermore, In vivo efficacy studies in NOD/SCID mice, using a systemic RPMI 8226 human multiple myeloma xenograft model, showed that DC-1-192 significantly prolonged survival (P=0.017). In addition, DC1-192 showed synergy with bortezomib and ibrutinib; synergy with ibrutinib was enhanced when CLL cells were co-cultured on CD40L-expressing fibroblasts in order to mimic the cytoprotective lymph node microenvironment (P = 0.01). Given that NF-κB plays a role in both bortezomib and ibrutinib resistance mechanisms, these data provide a strong rationale for the use of DC-1-192 in the treatment of NF-κB-driven cancers, particularly in the context of relapsed/refractory disease
Correlated variability of Mkn 421 at X-ray and TeV wavelengths on timescales of hours
Mkn 421 was observed for about two days with BeppoSAX, prior to and partly
overlapping the start of a 1 week continuous exposure with ASCA in April 1998,
as part of a world-wide multiwavelength campaign. A pronounced, well defined,
flare observed in X-rays was also observed simultaneously at TeV energies by
the Whipple Observatory's 10 m gamma-ray telescope. These data provide the
first evidence that the X-ray and TeV intensities are well correlated on
time-scales of hours.Comment: 4 pages, 1 figure, presented at the VERITAS Workshop on the TeV
Astrophysics of Extragalactic Object
Locating very high energy gamma ray sources with arc minute accuracy
The angular accuracy of gamma-ray detectors is intrinsically limited by the physical processes involved in photon detection. Although a number of point-like sources were detected by the COS-B satellite, only two were unambiguously identified by time signature with counterparts at longer wavelengths. By taking advantage of the extended longitudinal structure of Very High Energy gamma-ray showers, measurements in the TeV energy range can pinpoint source coordinates to arc minute accuracy. This was demonstrated using Cerenkov air shower imaging techniques. With two telescopes in coincidence, the individual event circular probable error will be 0.13 deg. The half-cone angle of the field of view is effectively 1 deg
Search for TeV Gamma-Rays from Shell-Type Supernova Remnants
If cosmic rays with energies <100 TeV originate in the galaxy and are
accelerated in shock waves in shell-type supernova remnants (SNRs), gamma-rays
will be produced as the result of proton and electron interactions with the
local interstellar medium, and by inverse Compton emission from electrons
scattering soft photon fields. We report on observations of two supernova
remnants with the Whipple Observatory's 10 m gamma-ray telescope. No
significant detections have been made and upper limits on the >500 GeV flux are
reported. Non-thermal X-ray emission detected from one of these remnants
(Cassiopeia A) has been interpreted as synchrotron emission from electrons in
the ambient magnetic fields. Gamma-ray emission detected from the
Monoceros/Rosette Nebula region has been interpreted as evidence of cosmic-ray
acceleration. We interpret our results in the context of these observations.Comment: 4 pages, 2 figures, to appear in the proceedings of 26th
International Cosmic Ray Conference (Salt Lake City, 1999
Section on Prospects for Dark Matter Detection of the White Paper on the Status and Future of Ground-Based TeV Gamma-Ray Astronomy
This is a report on the findings of the dark matter science working group for
the white paper on the status and future of TeV gamma-ray astronomy. The white
paper was commissioned by the American Physical Society, and the full white
paper can be found on astro-ph (arXiv:0810.0444). This detailed section
discusses the prospects for dark matter detection with future gamma-ray
experiments, and the complementarity of gamma-ray measurements with other
indirect, direct or accelerator-based searches. We conclude that any
comprehensive search for dark matter should include gamma-ray observations,
both to identify the dark matter particle (through the charac- teristics of the
gamma-ray spectrum) and to measure the distribution of dark matter in galactic
halos.Comment: Report from the Dark Matter Science Working group of the APS
commissioned White paper on ground-based TeV gamma ray astronomy (19 pages, 9
figures
Lp Fourier multipliers on compact Lie groups
In this paper we prove Lp multiplier theorems for invariant and non-invariant
operators on compact Lie groups in the spirit of the well-known
Hormander-Mikhlin theorem on Rn and its variants on tori Tn. We also give
applications to a-priori estimates for non-hypoelliptic operators. Already in
the case of tori we get an interesting refinement of the classical multiplier
theorem.Comment: 22 pages; minor correction
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