Intraocular correction of high-degree ametropia using individual multifocal LentisMPlus IOL

ABSTRACT Background. For surgical correction of high-degree ametropia aggravated with astigmatism the following options are available: excimer laser correction; phakic lens implantation; bioptika – a combination of ablating the transparent crystalline lens (ATL) with implantation of multifocal toric diopter IOL of standard series and LASIK for the correction of a residual refractive error, ATL using 2 IOLs according to the Technology «Piggy Back»; additional meniscus IOL implantation «Add-On»; ATL with implantation of an individual multifocal toric IOL. Purpose. To show a possibility of intraocular correction of high ametropia aggravated with astigmatism using toric multifocal custom IOLs. Material and methods. We observed two patients: the first female patient, 39 years old with a diagnosis of OU: high myopia, compound myopic astigmatism, initial complicated cataract, moderate amblyopia, peripheral chorioretinal degeneration (PCRD). On admission the distance visual acuity was vis OD=0.01 sph (-) 15.5 D cyl (-) 2.5 D ax 0°=0.6; vis OS=0.01 sph (-) 18.0 D cyl (-) 2.5 D ax 0°=0.5. The second patient was a 35-year woman with a diagnosis of OU: high hyperopia, compound hyperopic astigmatism, moderate amblyopia. Distance visual acuity on admission was OD=0.03 sph (+) 8.0 D cyl (+) 1.5 D ax 95°=0.5; OS=0.03 sph (+) 8.0 D cyl (+) 0.75 D ax 75°=0.6. Individual multifocal toric IOLs were implanted in both patents after the removal of the lens phacoemulsification. All standard ophthalmic examinations were used as well as the ultrasound biomicroscopy (UBM). Results. In the follow-up: 6 months after the surgery in the first patient the uncorrected visual acuity (UCVA) was far vis OD=0.6, vis OS=0.5, near vis OD=0.4, vis OS=0.5, middle distance vis OD=0.4, vis OS=0.4. The second patient 3 months after surgery had the UCVA far vis OD=0.5, vis OS=0.6, near vis OD=0.4, vis OS=0.5, middle distance vis OD=0.2, vis OS=0.3. The maximum possible distance visual acuity was achieved in both cases. Conclusion. The LentisMplus (Otsulentis) IOL with a toric component, made custom taking into account individual features of eyes allow to achieve clinical and functional results declared by the manufacturer of these lenses for the standard diopter range

CYTOKINE PROFILE IN CHILDREN WITH ASTHMA, COMBINED WITH CHRONIC OPISTHORCHOSIS

Current epidemiological studies show some correlation of prevalence and intensity of clinical manifestations of asthma, with the level of the intestinal parasites infestation in the studied population. Apparently, such a relationship of intestinal helminth invasion and allergic inflammation are formed on the basis of the «overlapping» or bipolar immunological mechanisms. In this context, there was planned and carried out the study concerning the relationship of clinical and functional parameters that characterize the intensity of inflammation in asthma and cytokine profile depending on the presence of chronic infestation Opisthorchis felineus. The study involved 212 patients (mean age 9,35 ± 0,12 years). It was established that the chronic infestation O. felineus in patients with asthma is characterized by the high levels of interleukin (IL) Th1 profile (IL 2, 10, IFN y) and low values of pro-inflammatory cytokines (IL 4, 5), which is associated with a lower degree of nonspecific airway reactivity.Key words: Opisthorchis felineus, children, cytokines, IL 4, IL 5, IL 2, IL 10, IFN y

ОСОБЕННОСТИ ЦИТОКИНОВОГО ПРОФИЛЯ У ДЕТЕЙ, СТРАДАЮЩИХ БРОНХИАЛЬНОЙ АСТМОЙ, В СОЧЕТАНИИ С ХРОНИЧЕСКИМ ОПИСТОРХОЗОМ

Current epidemiological studies show some correlation of prevalence and intensity of clinical manifestations of asthma, with the level of the intestinal parasites infestation in the studied population. Apparently, such a relationship of intestinal helminth invasion and allergic inflammation are formed on the basis of the «overlapping» or bipolar immunological mechanisms. In this context, there was planned and carried out the study concerning the relationship of clinical and functional parameters that characterize the intensity of inflammation in asthma and cytokine profile depending on the presence of chronic infestation Opisthorchis felineus. The study involved 212 patients (mean age 9,35 ± 0,12 years). It was established that the chronic infestation O. felineus in patients with asthma is characterized by the high levels of interleukin (IL) Th1 profile (IL 2, 10, IFN y) and low values of pro-inflammatory cytokines (IL 4, 5), which is associated with a lower degree of nonspecific airway reactivity.Key words: Opisthorchis felineus, children, cytokines, IL 4, IL 5, IL 2, IL 10, IFN y.Современные эпидемиологические исследования демонстрируют некоторую взаимосвязь распространенности, интенсивности клинических проявлений астмы, с уровнем гельминтной инвазии в исследуемой популяции. По всей видимости, такие взаимоотношения гельминтной инвазии и аллергического воспаления формируются на основе «перекрывающихся» или разнополярных иммунологических механизмов. В этой связи спланировано и проведено исследование взаимосвязи клинико-функциональных параметров, характеризующих интенсивность воспаления при астме и цитокинового профиля при хронической инвазии Opisthorchis felineus. В исследовании приняли участие 212 пациентов (средний возраст 9,35 ± 0,12 лет). Установлено, что хроническая инвазия O. felineus у больных астмой характеризуется высоким уровнем интерлейкинов (IL) Th1 профиля (IL 2, 10, IFN y) и низкими значениями провоспалительных цитокинов (IL 4, 5), что сопряжено с меньшей степенью неспецифической реактивности дыхательных путей.Ключевые слова: Opisthorchis felineus, дети, цитокины, IL 4, IL 5, IL 2, IL 10, IFN y. (Педиатрическая фармакология –2011; 8(2): 32-39

Functional supramolecular systems: Design and applications

The interest in functional supramolecular systems for the design of innovative materials and technologies, able to fundamentally change the world, is growing at a high pace. The huge array of publications that appeared in recent years in the global literature calls for systematization of the structural trends inherent in the formation of these systems revealed at different molecular platforms and practically useful properties they exhibit. The attention is concentrated on the topics related to functional supramolecular systems that are actively explored in institutes and universities of Russia in the last 10-15 years, such as the chemistry of host-guest complexes, crystal engineering, self-assembly and self-organization in solutions and at interfaces, biomimetics and molecular machines and devices