57 research outputs found
Infrared thermography study of the fatigue crack propagation
The work is devoted to the experimental study of heat dissipation process caused by fatigue crack propagation. To investigate a spatial and time temperature evolution at the crack tip set of experiments was carried out using specimens with pre-grown centered fatigue crack. An original mathematical algorithm for experimental data treatment was developed to obtain a power of heat source caused by plastic deformation atΒ crack tip. The algorithm includes spatial-time filtration and relative motion compensation procedures. Based onΒ the results of mathematical data treatment, we proposed a way to estimate the values of J-integral and stress intensity factor for cracks with pronounced the plastic zone
Microlensing effects and structure of gravitational lens systems
A study of gravitational microlensing of distant objects is presented. We performed simulations of light curves and trajectories of the image centroid of an extended source in the ChangβRefsdal lens with shear and continual dark matter. Various brightness distributions over the source (Gaussian, power-law, ShakuraβSynyaev accretion disc) have been studied. We considered in detail approximate relations and corresponding algorithms used to fit observational data on high amplification events (HAE). The results are applied to interpretation of HAE observed by OGLE and GLITP groups. The source size and caustic crossing moment are estimated from these data, however, the determination of the brightness profile is statistically not reliable
Infrared thermography study of the fatigue crack propagation
The work is devoted to the experimental study of heat dissipation process caused by fatigue crack propagation. To investigate a spatial and time temperature evolution at the crack tip set of experiments was carried out using specimens with pre-grown centered fatigue crack. An original mathematical algorithm for experimental data treatment was developed to obtain a power of heat source caused by plastic deformation atΒ crack tip. The algorithm includes spatial-time filtration and relative motion compensation procedures. Based onΒ the results of mathematical data treatment, we proposed a way to estimate the values of J-integral and stress intensity factor for cracks with pronounced the plastic zone
Π‘ΠΠΠΠ ΠΠΠΠΠ ΠΠΠΠΠΠΠ, ΠΠΠΠΠΠΠΠΠΠ Π ΠΠ ΠΠΠΠΠ ΠΠ Π Π ΠΠΠΠΠ’ΠΠ ΠΠΠ‘Π£ΠΠΠΠΠ ΠΠΠΠ‘Π’ΠΠΠ’ΠΠΠ‘Π’Π Π£ ΠΠΠ¦ΠΠΠΠ’ΠΠ Π‘ ΠΠΠ€ΠΠ ΠΠ’ΠΠ ΠΠΠΠΠΠ ΠΠ
Aim. The estimate insulin resistance in myocardial infarction. Patients and methods. The study involved 200 patients with myocardial infarction, in which on the 1st and 12th day of hospitalization measured glucose, insulin, insulin resistance index (IR), lipid profile, the concentration of adipokines and ghrelin. Results. IR was detected in 77% of patients and was associated with a history of factors of cardiovascular risk, adverse clinical course of the disease, lipid disorders. The most important marker was the level of free fatty acids. High risk associated with increased in 9 times the concentration of free fatty acids in blood plasma. Patients with IR observed increased concentrations of leptin, resistin, and reduced the protective effect of adiponectin. The high specificity and sensitivity characteristic of the concentration of ghrelin: its reduction by 4 times in the acute phase of myocardial infarction increases the risk of MI by 78%. Conclusions. Significant risk factors for MI myocardial infarction, along with insulinemia and glycemia, is to increase the concentration of free fatty acids and the disbalance in the system adipokines against deficiency of ghrelin in acute and early recovery periods of the disease. Free fatty acids and ghrelin are promising markers to stratify the risk of insulin resistance in patients with myocardial infarction.Β Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ: ΠΎΡΠ΅Π½ΠΊΠ° ΠΈΠ½ΡΡΠ»ΠΈΠ½ΠΎΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΡΡΠΈ ΠΏΡΠΈ ΠΈΠ½ΡΠ°ΡΠΊΡΠ΅ ΠΌΠΈΠΎΠΊΠ°ΡΠ΄Π°. ΠΠ°ΡΠΈΠ΅Π½ΡΡ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ: Β Π² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π²ΠΊΠ»ΡΡΠ΅Π½ΠΎ 200 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΈΠ½ΡΠ°ΡΠΊΡΠΎΠΌ ΠΌΠΈΠΎΠΊΠ°ΡΠ΄Π°,Β Β Ρ ΠΊΠΎΡΠΎΡΡΡ
Π½Π° 1-Π΅ ΠΈ 12-Π΅ ΡΡΡ Π³ΠΎΡΠΏΠΈΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ Π³Π»ΡΠΊΠΎΠ·Ρ, ΠΈΠ½ΡΡΠ»ΠΈΠ½Π°, ΠΈΠ½Π΄Π΅ΠΊΡ ΠΈΠ½ΡΡΠ»ΠΈΠ½ΠΎΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΡΡΠΈ (ΠΠ ), ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ Π»ΠΈΠΏΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠΈΠ»Ρ, ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡ Π°Π΄ΠΈΠΏΠΎΠΊΠΈΠ½ΠΎΠ² ΠΈ Π³ΡΠ΅Π»ΠΈΠ½Π°. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ: ΠΠ Π±ΡΠ»Π° Π²ΡΡΠ²Π»Π΅Π½Π° Ρ 77% Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΈ Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π»Π°ΡΡ Ρ Π½Π°Π»ΠΈΡΠΈΠ΅ΠΌ Π² Π°Π½Π°ΠΌΠ½Π΅Π·Π΅ ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎ-ΡΠΎΡΡΠ΄ΠΈΡΡΠΎΠ³ΠΎ ΡΠΈΡΠΊΠ°, Π½Π΅Π±Π»Π°Π³ΠΎΠΏΡΠΈΡΡΠ½ΡΠΌ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ΠΌ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ, Π½Π°ΡΡΡΠ΅Π½ΠΈΠ΅ΠΌ Π»ΠΈΠΏΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π°. ΠΠ°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠ²Π½ΡΠΌ ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠΌ ΠΎΠΊΠ°Π·Π°Π»ΡΡ ΡΡΠΎΠ²Π΅Π½Ρ ΡΠ²ΠΎΠ±ΠΎΠ΄Π½ΡΡ
ΠΆΠΈΡΠ½ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ. ΠΡΡΠΎΠΊΠΈΠΉ ΡΠΈΡΠΊ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΠ ΡΠ²ΡΠ·Π°Π½ Ρ Π²ΠΎΠ·ΡΠ°ΡΡΠ°Π½ΠΈΠ΅ΠΌΒ Π² 9 ΡΠ°Π· ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΡΠ²ΠΎΠ±ΠΎΠ΄Π½ΡΡ
ΠΆΠΈΡΠ½ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ Π² ΠΏΠ»Π°Π·ΠΌΠ΅ ΠΊΡΠΎΠ²ΠΈ. Π£ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ ΠΠ Π½Π°Π±Π»ΡΠ΄Π°Π΅ΡΡΡ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ Π»Π΅ΠΏΡΠΈΠ½Π°, ΡΠ΅Π·ΠΈΡΡΠΈΠ½Π°, ΠΈ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ Π·Π°ΡΠΈΡΠ½ΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π°Π΄ΠΈΠΏΠΎΠ½Π΅ΠΊΡΠΈΠ½Π°. ΠΡΡΠΎΠΊΠ°Ρ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΡ ΠΈ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½Π° Π΄Π»Ρ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ Π³ΡΠ΅Π»ΠΈΠ½Π°: Π΅Π΅ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ Π² 4 ΡΠ°Π·Π° Π² ΠΎΡΡΡΠΎΠΌ ΠΏΠ΅ΡΠΈΠΎΠ΄Π΅ ΠΈΠ½ΡΠ°ΡΠΊΡΠ° ΠΌΠΈΠΎΠΊΠ°ΡΠ΄Π° ΠΏΠΎΠ²ΡΡΠ°Π΅Ρ ΡΠΈΡΠΊ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΠ Π½Π° 78%.ΠΡΠ²ΠΎΠ΄Ρ: Π·Π½Π°ΡΠΈΠΌΡΠΌΠΈ ΡΠ°ΠΊΡΠΎΡΠ°ΠΌΠΈ ΡΠΈΡΠΊΠ° ΠΠ ΠΏΡΠΈ ΠΈΠ½ΡΠ°ΡΠΊΡΠ΅ ΠΌΠΈΠΎΠΊΠ°ΡΠ΄Π°, Π½Π°ΡΡΠ΄Ρ Ρ ΠΈΠ½ΡΡΠ»ΠΈΠ½Π΅ΠΌΠΈΠ΅ΠΉ ΠΈ Π³Π»ΠΈΠΊΠ΅ΠΌΠΈΠ΅ΠΉ, ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅Β ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ Β ΡΠ²ΠΎΠ±ΠΎΠ΄Π½ΡΡ
ΠΆΠΈΡΠ½ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ ΠΈ Π΄ΠΈΡΠ±Π°Π»Π°Π½Ρ Π² ΡΠΈΡΡΠ΅ΠΌΠ΅ Π°Π΄ΠΈΠΏΠΎΠΊΠΈΠ½ΠΎΠ²Β Β Π½Π° ΡΠΎΠ½Π΅ Π΄Π΅ΡΠΈΡΠΈΡΠ° Π³ΡΠ΅Π»ΠΈΠ½Π° Π² ΠΎΡΡΡΠΎΠΌ ΠΈ ΡΠ°Π½Π½Π΅ΠΌ Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΌ ΠΏΠ΅ΡΠΈΠΎΠ΄Π°Ρ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ. Π‘Π²ΠΎΠ±ΠΎΠ΄Π½ΡΠ΅ ΠΆΠΈΡΠ½ΡΠ΅ ΠΊΠΈΡΠ»ΠΎΡΡ ΠΈ Π³ΡΠ΅Π»ΠΈΠ½ ΡΠ²Π»ΡΡΡΡΡ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌΠΈ ΠΌΠ°ΡΠΊΠ΅ΡΠ°ΠΌΠΈ Π΄Π»Ρ ΡΡΡΠ°ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΡΠΈΡΠΊΠ° ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΈΠ½ΡΡΠ»ΠΈΠ½ΠΎΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΡΡΠΈ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ ΠΈΠ½ΡΠ°ΡΠΊΡΠΎΠΌΒ Β ΠΌΠΈΠΎΠΊΠ°ΡΠ΄Π°.
Π ΠΠ‘ΠΠ ΠΠ‘Π’Π ΠΠΠΠΠΠΠ‘Π’Π¬ ΠΠΠ©ΠΠΠΠ ΠΠΠΠΠ ΠΠΠ Π£ ΠΠΠ’ΠΠ Π ΠΠΠ ΠΠΠΠ ΠΠ§ΠΠΠ ΠΠΠΠ‘Π’ΠΠ Π₯ΠΠΠ: ΠΠΠΠΠΠ ΠΠΠΠΠΠ Π ΠΠΠ’ΠΠΠΠΠΠΠΠ― ΠΠΠΠΠΠΠΠΠΠΠΠΠ§ΠΠ‘ΠΠΠΠ ΠΠ‘Π‘ΠΠΠΠΠΠΠΠΠ― EUROPREVALL
According to numerous surveys food allergy affects up to 2β6% of population in different countries and varies due to numerous factors including the prevalence of helminths infestation. The food allergy prevalence data in Russia are based on official medical statistics. The study was performed as part of Β«The Prevalence, Cost and Basis of Food Allergy Across EuropeΒ» (EU funded project βΒ FP6-2006-TTC-TU-5 Proposal 045879 EuroPrevall). The aim is to create the concept of food allergy in children in opisthorchiasis endemic area based on epidemiological study of the prevalence, risk factors and clinical features. The main objective of the study will be the working out of the food safety regulations. This article describes the study design and its methodology.Β Π‘ΠΎΠ³Π»Π°ΡΠ½ΠΎ Π΄Π°Π½Π½ΡΠΌ ΡΡΠ΄Π° ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»Π΅ΠΉ, ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΡΡΡ ΠΏΠΈΡΠ΅Π²ΠΎΠΉ Π°Π»Π»Π΅ΡΠ³ΠΈΠΈ Π² ΠΌΠΈΡΠ΅ ΡΠΎΡΡΠ°Π²Π»ΡΠ΅Ρ 2β6%, Π²Π°ΡΡΠΈΡΡΡ Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ ΠΌΠ½ΠΎΠ³ΠΎΡΠΈΡΠ»Π΅Π½Π½ΡΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ², Π²ΠΊΠ»ΡΡΠ°Ρ ΠΏΠΎΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΡ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ Π³Π΅Π»ΡΠΌΠΈΠ½ΡΠ½ΡΠΌΠΈ ΠΈΠ½Π²Π°Π·ΠΈΡΠΌΠΈ. Π‘Π²Π΅Π΄Π΅Π½ΠΈΡ ΠΎ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΡΡΠΈ ΠΏΠΈΡΠ΅Π²ΠΎΠΉ Π°Π»Π»Π΅ΡΠ³ΠΈΠΈ Π² Π ΠΎΡΡΠΈΠΈ ΠΎΡΠ½ΠΎΠ²Π°Π½Ρ Π½Π° Π΄Π°Π½Π½ΡΡ
ΠΎΡΠΈΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΡΡΠ°ΡΠΈΡΡΠΈΠΊΠΈ. ΠΠ°ΡΡΠΎΡΡΠ°Ρ ΡΠ°Π±ΠΎΡΠ° Π²ΡΠΏΠΎΠ»Π½Π΅Π½Π° Π² ΡΠ°ΠΌΠΊΠ°Ρ
Β«ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΡΡΠΈ, ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎ-ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π·Π½Π°ΡΠ΅Π½ΠΈΡ ΠΈ ΠΎΡΠ½ΠΎΠ² ΠΏΠΈΡΠ΅Π²ΠΎΠΉ Π°Π»Π»Π΅ΡΠ³ΠΈΠΈ Π² ΠΠ²ΡΠΎΠΏΠ΅Β» (Β«The Prevalence, Cost and Basis of Food Allergy Across EuropeΒ»; Π³ΡΠ°Π½Ρ VI ΡΠ°ΠΌΠΎΡΠ½ΠΎΠΉ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ ΠΠ²ΡΠΎΡΠΎΡΠ·Π° βΒ FP6-2006-TTC-TU-5 Proposal 045879 EuroPrevall). Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠΎΡΡΠΎΠΈΡ Π² ΡΠΎΡΠΌΡΠ»ΠΈΡΠΎΠ²ΠΊΠ΅ Π½ΠΎΠ²ΠΎΠΉ ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΠΈ ΠΏΠΈΡΠ΅Π²ΠΎΠΉ Π°Π»Π»Π΅ΡΠ³ΠΈΠΈ Ρ Π΄Π΅ΡΠ΅ΠΉ Π² ΠΌΠΈΡΠΎΠ²ΠΎΠΌ ΠΎΡΠ°Π³Π΅ ΠΎΠΏΠΈΡΡΠΎΡΡ
ΠΎΠ·Π° Π½Π° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΡΡΠΈ, ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΡΠΈΡΠΊΠ°, ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ Π±ΠΎΠ»Π΅Π·Π½ΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ Π² ΡΠΎΠ·Π΄Π°Π½ΠΈΠΈ Π½Π°ΡΡΠ½ΠΎΠΉ Π±Π°Π·Ρ Π΄Π»Ρ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠΈ ΡΠ΅Π³Π»Π°ΠΌΠ΅Π½ΡΠΎΠ² Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ² ΠΏΠΈΡΠ°Π½ΠΈΡ. Π‘ΡΠ°ΡΡΡ ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π° Π²ΠΎΠΏΡΠΎΡΠ°ΠΌ ΠΏΠ»Π°Π½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ.
Occupational reporiductive system diseases in female workers employed at worplaces with harmful working conditions
The paper outlines the data obtained in the course of long-term research dedicated to studying the extent to which re-productive system pathologies in workers with high-risk occupations are occupationally induced. Their peculiarity is joint impacts of various occupational factors (for example, impacts exerted by chemicals together with physical and biological factors, and labor hardness and intensity as well) on a female body.
Our research goal was to examine the extent to which reproductive system pathologies in workers with high-risk occupations were occupationally induced. To achieve it, we applied statistical estimate of correlation between health disorders and work.
Our occupational group included a number of occupations with harmful or hazardous working conditions in civil en-gineering, metallurgy, chemical industry, polymer-processing industry, and health care as well. As a rule, working condi-tions class of workers from the examined groups varied from 3.1 to 3.3; and occupation with permissible working conditions were used as a comparative group.
The research results revealed that there are certain occupations with high risk of reproductive health disorders evolvement and infants development pathologies evolvement. They are:
β model makers and checkers in civil engineering and crane operators at a metallurgic plant;
β analysts at chemical analysis laboratories, chemical engineers in chemical industry (including petrochemical plants, polymer-processing plants, and organic synthesis plants);
β surgeons, obstetrician-gynecologists, midwives, surgical nurses working in in-patient departments.
Estimate of correlation and occupational dependence of reproductive system diseases on working conditions revealed that women with harmful working conditions (3.1β3.3 hazard class) had defective pregnancies or labor pathologies which had strong and average correlation with working conditions. Health disorders in newborns were estimated as per very strong corre-lation with mother's work. Thus, we can state that a mother occupational risk induction for a child health is fundamentally proved. On the basis of the obtained results we rank female workers with 3 class 2 harm degree working conditions as having an occupation with high risks of reproductive health disorders.
We worked out an algorithm aimed at managing these risks; it should be applied in order to lower occupational risks for reproduction in female workers
Liver pathology in hypo- and hyperthyroidism (literature review)
The thyroid gland is an endocrine organ, the product of which are iodinecontaining
hormones - triiodothyronine and thyroxine. Violation of the concentration of iodothyronines
in the blood plasma can lead to the occurrence of pathological processes in
other organs, in particular, the liver. The hypothyroid state leads to a decrease in the synthetic
function of the liver, worsens the course of the metabolic syndrome, leading to the
development of non-alcoholic fatty liver disease, morphologically manifested as steatohepatitis
with minimal changes. In hyperthyroidism, in addition to autoimmune and druginduced
hepatitis, there are cholestatic and hepatitis forms of liver damage. Cholestatic lesion
consists in the development of centrilobular intrahepatocyte cholestasis, clinically and
laboratory manifested by the development of cholestatic syndrome. Hepatitis liver damage
is manifested by the development of clinical, laboratory and morphological signs of acute
hepatitis. The review provides up-to-date information on biochemistry, theories of development,
pathogenesis and pathomorphology of liver pathologies that occur in thyroid gland
pathologies accompanied by hypo- and hyperthyroidism. Data from both clinical and experimental
studies are presented
Innovation and development prospects of pre-university education of Saratov State Medical University
The article considers innovative methods used in the pre-university education at Saratov State Medical University and directed to the modernization of educational program. It points out that competence-based approach includes the following components β problem teaching and adaptive system, heuristic teaching, personal approach to teaching, computerization, distant education technologies and integration-module technolog
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