Single group VBM analysis with additional covariates (PCs): the statistical map represents the correlation between PC2 and GM volume in AS children overlaid on the study-specific grey matter template (created by FSL-VBM protocol) on the sagittal, coronal and axial plane.

<p>Single group VBM analysis with additional covariates (PCs): the statistical map represents the correlation between PC2 and GM volume in AS children overlaid on the study-specific grey matter template (created by FSL-VBM protocol) on the sagittal, coronal and axial plane.</p

The two-dimensional biplot shows the projection of the data on the first two PCs.

<p>It colors each point according to the gender and shows the loading of each variable on the first two principal components with a circle of correlation.</p

A chart of the correlation matrix.

<p>The distribution of each variable is shown on the diagonal. On the bottom of the diagonal: the bivariate scatter plots with a fitted line are displayed. On the top of the diagonal: the value of the correlation plus the significance level as stars. Abbreviations: CSF, cerebrospinal fluid; GM, grey matter; WM, white matter; PC, principal component.</p

Size and labelled anatomical structures of the significant clusters (p < 0.05, corrected).

<p>The voxel coordinates (in millimeter) in MNI standard space for the location of the maximum intensity are presented. The probability values are scaled from 0 to 100 and indicate the probability of the cluster being a member of the different labelled regions within the atlas.</p

The coefficients for the first three principle components and the variance explained.

<p>The coefficients for the first three principle components and the variance explained.</p

Between-group VBM analysis: the statistical map is overlaid on the study-specific grey matter template (created by FSL-VBM protocol) on axial plane.

<p>Red-yellow clusters show grey matter volumetric reduction in children with Angelman syndrome compared to controls.</p