Cluster-based Vibration Analysis of Structures with GSP

This article describes a divide-and-conquer strategy suited for vibration monitoring applications. Based on a low-cost embedded network of microelectromechanical accelerometers, the proposed architecture strives to reduce both power consumption and computational resources. Moreover, it eases the sensor deployment on large structures by exploiting a novel clustering scheme, which consists of unconventional and nonoverlapped sensing configurations. Signal processing techniques for inter- and intracluster data assembly are introduced to allow for a fullscale assessment of the structural integrity. More specifically, the capability of graph signal processing is adopted for the first time in vibration-based monitoring scenarios to capture the spatial relationship between acceleration data. The experimental validation, conducted on a steel beam perturbed with additive mass, reveals high accuracy in damage detection tasks. Deviations in spectral content and mode shape envelopes are correctly revealed regardless of environmental factors and operational uncertainties. Furthermore, an additional key advantage of the implemented architecture relies on its compliance with blind modal investigations, an approach that favors the implementation of autonomous smart monitoring systems

Clinical presentation of calmodulin mutations: the International Calmodulinopathy Registry

AIMS: Calmodulinopathy due to mutations in any of the three CALM genes (CALM1-3) causes life-threatening arrhythmia syndromes, especially in young individuals. The International Calmodulinopathy Registry (ICalmR) aims to define and link the increasing complexity of the clinical presentation to the underlying molecular mechanisms. METHODS AND RESULTS: The ICalmR is an international, collaborative, observational study, assembling and analysing clinical and genetic data on CALM-positive patients. The ICalmR has enrolled 140 subjects (median age 10.8 years [interquartile range 5-19]), 97 index cases and 43 family members. CALM-LQTS and CALM-CPVT are the prevalent phenotypes. Primary neurological manifestations, unrelated to post-anoxic sequelae, manifested in 20 patients. Calmodulinopathy remains associated with a high arrhythmic event rate (symptomatic patients, n = 103, 74%). However, compared with the original 2019 cohort, there was a reduced frequency and severity of all cardiac events (61% vs. 85%; P = .001) and sudden death (9% vs. 27%; P = .008). Data on therapy do not allow definitive recommendations. Cardiac structural abnormalities, either cardiomyopathy or congenital heart defects, are present in 30% of patients, mainly CALM-LQTS, and lethal cases of heart failure have occurred. The number of familial cases and of families with strikingly different phenotypes is increasing. CONCLUSION: Calmodulinopathy has pleiotropic presentations, from channelopathy to syndromic forms. Clinical severity ranges from the early onset of life-threatening arrhythmias to the absence of symptoms, and the percentage of milder and familial forms is increasing. There are no hard data to guide therapy, and current management includes pharmacological and surgical antiadrenergic interventions with sodium channel blockers often accompanied by an implantable cardioverter-defibrillator

Modal Analysis of Structures with Low-cost Embedded Systems

This paper presents a low-cost system that permits to provide structural modal analysis from a number of synchronized MEMS accelerometers distributed along the structure. The communication and computational effort is distributed among the nodes and data are provided real-time. Synchronization between sensors and accuracy of the measures permit to elaborate detailed modal analysis of the buildings. Experiments on real testbeds and structures demonstrate that the accuracy of the modal analysis is similar to the simulations executed using the models of the structures, and confirm that complex structural health evaluations are possible from a set of low-cost sensors