7 research outputs found
Short-term effects of synchronized vs. nonsynchronized NIPPV in preterm infants: study protocol for an unmasked randomized crossover trial
Short-term effects of synchronized vs. non-synchronized NIPPV in preterm infants: study protocol for an unmasked randomized crossover trial
Abstract Background Non-invasive ventilation (NIV) has been recommended as the best respiratory support for preterm infants with respiratory distress syndrome (RDS). However, the best NIV technique to be used as first intention in RDS management has not yet been established. Nasal intermittent positive pressure ventilation (NIPPV) may be synchronized (SNIPPV) or non-synchronized to the infantâs breathing efforts. The aim of the study is to evaluate the short-term effects of SNIPPV vs. NIPPV on the cardiorespiratory events, trying to identify the best ventilation modality for preterm infants at their first approach to NIV ventilation support. Methods An unmasked randomized crossover study with three treatment phases was designed. All newborn infants <â32âweeks of gestational age with RDS needing NIV ventilation as first intention or after extubation will be consecutively enrolled in the study and randomized to the NIPPV or SNIPPV arm. After stabilization, enrolled patients will be alternatively ventilated with two different techniques for two time frames of 4âh each. NIPPV and SNIPPV will be administered with the same ventilator and the same interface, maintaining continuous assisted ventilation without patient discomfort. During the whole duration of the study, the patientâs cardiorespiratory data and data from the ventilator will be simultaneously recorded using a polygraph connected to a computer. The primary outcome is the frequency of episodes of oxygen desaturation. Secondary outcomes are the number of the cardiorespiratory events, FiO2 necessity, newborn pain score evaluation, synchronization index, and thoracoabdominal asynchrony. The calculated sample size was of 30 patients. Discussion It is known that NIPPV produces a percentage of ineffective acts due to asynchronies between the ventilator and the infantâs breaths. On the other hand, an ineffective synchronization could increase work of breathing. Our hypothesis is that an efficient synchronization could reduce the respiratory work and increase the volume per minute exchanged without interfering with the natural respiratory rhythm of the patient with RDS. The results of this study will allow us to evaluate the effectiveness of the synchronization, demonstrating whether SNIPPV is the most effective non-invasive ventilation mode in preterm infants with RDS at their first approach to NIV ventilation. Trial registration ClinicalTrials.gov NCT03289936 . Registered on September 21, 2017
Supplementary suckling technique with expressed breast milk can increase the belief in breastfeeding
In Tanzania in 2015 more than 100,000 Severe Acute Malnourished (SAM) cases were estimated, with
high risk of dying. SAM infants underâ6 months (Uâ6 mo) need special care and should always be treated
as inpatient. If it is possible to restore Exclusive Breast Feeding (EBF), therapeutic feeds can be best
delivered by the Supplementary Suckling Technique (SST). A male infant, born at term with a body weight
(BW) of 3100 g, was admitted in hospital at 6 weeks of age with a BW of 1550 g. The child was diagnosed
as marasmatic SAM. He was started on therapeutic milk administered by SST. Mother was instructed in
proper SST use and counseled in order to reâestablish effective EBF. As weight gain was maintained, SST
was stopped and the child was put on EBF, but BW started to decrease again. SST was then applied using
Expressed Breast Milk (EBM), gradually stepped down and stopped. Since BW started to decrease again it
emerged that the mother decided by herself to start again to administer EBM by SST but in insuficient
quantity. She was invited to breastfeed frequently under supervision, creating a better awareness of
breastfeeding practices. Since the child showed correct weight gain on EBF he was discharged, with a BW
of 2420 g. According to our experience SST with EBM could be useful in developing countries to increase
awareness and belief on successful breast feeding
Complementary Feeding: Recommendations for the Introduction of Allergenic Foods and Gluten in the Preterm Infant
Background: The aim of this systematic review is to analyze the available literature on the
introduction of allergenic foods and gluten among preterm infants. Methods: A systematic review of
published studies concerning the introduction of gluten and allergenic foods in preterm infants was
performed on PubMed and on the Cochrane Library. Results: Of the 174 PubMed results, 15 papers
were considered suitable for the review. A total of 83 records were identified through the Cochrane
Library search; eight papers were included in the review. Additional papers were identified from the
reference lists of included studies. A secondary search was conducted on the same databases to find
recommendations and advice regarding healthy full-term infants that could be translated to preterm
infants. Therefore, 59 additional papers were included in the review. Conclusions: Current guidelines
for the introduction of solid food cannot be directly transposed to preterm infants. Further research is
needed to provide evidence-based guidelines regarding weaning in preterm infants. To date, we can
suggest that in preterm infants allergenic foods and gluten may be introduced when complementary
feeding is started, any time after 4 months of corrected age, avoiding delayed introduction and
irrespective of infants\u2019 relative risk of developing allergy. Avoiding large amounts of gluten during
the first few weeks after gluten introduction and during infancy is advised, despite limited evidence
to support this recommendation
Parents' Perspective of Antibiotic Usage in Children: A Nationwide Survey in Italy
Antibiotics represent the most widely prescribed drugs in children worldwide, both in hospital and community settings. A comprehensive approach to understanding the reasons and determinants of antibiotic prescription in the pediatric age is needed. This study aimed to assess parents' attitudes and perspectives about antibiotic use