Total Synthesis of (+)-Aplykurodinone‑1

Starting from (<i>R</i>)-citronellic acid and (<i>R</i>)-seudenol, the total synthesis of (+)-aplykurodinone-1, a highly degraded marine steroid, has been achieved in 11 steps and in 19% overall yield with excellent stereochemical control. In addition to the features such as an Ireland–Claisen rearrangement, an intramolecular carbonyl–ene cyclization, and an intramolecular Michael addition, the present synthetic strategy is accomplished without the use of protecting groups

An Improved Moth-Flame Algorithm for Human–Robot Collaborative Parallel Disassembly Line Balancing Problem

In the context of sustainable development strategies, the recycling of discarded products has become increasingly important with the development of electronic technology. Choosing the human–robot collaborative disassembly mode is the key to optimizing the disassembly process and ensuring maximum efficiency and benefits. To solve the problem of human–robot cooperative parallel dismantling line balance, a mixed integer programming model is established and verified by CPLEX. An improved Moth-Flame Optimization (IMFO) algorithm is proposed to speed up convergence and optimize the disassembly process of various products. The effectiveness of IMFO is evaluated through multiple cases and compared with other heuristics. The results of these comparisons can provide insight into whether IMFO is the most appropriate algorithm for the problem presented

The Potential of a Novel Nanofluid in Enhancing Oil Recovery

A surface-active and “green” flooding agent, modified nanocellulose (NC), which is expected to be an alternative to the current flooding systems for enhancing oil recovery (EOR), was provided in this work. The physical properties of the NC samples including dispersity, rheology, phase behavior, emulsifiability, etc., as a function of mass fraction and charge density, were comprehensively studied to evaluate their EOR potential. The results indicate that this modified nanomaterial could be well dispersed in 1 wt % NaCl brine, forming a series of homogeneous nanofluids at the concentration above 0.4 wt %. Rheological analysis evidenced the viscoelastic properties and pronounced shear-thinning behavior of the nanofluids. Because of the presence of the active groups, the dynamic interfacial tension (Oil/Nanofluid) decreased to an order of 10^–1mN/m, which accordingly promotes the microscopic recovery efficiency through an emulsification effect. It was also observed that the emulsifiability of the nanofluids was closely related to the charge density. Visual EOR experiments were conducted in a micromodel, from which two mechanisms, (1) sweep volume improvement and (2) emulsification and entrainment, were established for NC nanofluid flooding. As an eco-friendly material, this nanofluid is supposed to be a promising flooding agent in the near future

Surface Plasmon Effect Dominated High-Performance Triboelectric Nanogenerator for Traditional Chinese Medicine Acupuncture

Available, effectively converting low-frequency vibration into available electricity, triboelectric nanogenerator (TENG) is always research hot nowadays. However, the enhancing effect of the existing methods for the output have all sorts of drawbacks, i.e., low efficiency and unstable, and its practical applications still need to be further explored. Here, leveraging core-shell nanoparticles Ag@SiO2 doping into tribo-materials generates the surface plasmon effect to boost the output performance of the TENG. On one hand, the shell alleviated the seepage effect from conventional nanoparticles; on the other hand, the surface plasmon effect enabled the core-shell nanoparticles to further boost the output performance of TENG. We circumvent the limitations and present a TENG whose output power density can be up to 4.375 mW/cm2. Points is that this article novelty investigate the high-performance TENG applicating for traditional Chinese medicine and develop a pratical self-powered acupuncture system. This technology enables rapid, routine regulation of human health at any age, which has potential applications in nearly any setting across healthcare platforms alike.FIMA

Surface Plasmon Effect Dominated High-Performance Triboelectric Nanogenerator for Traditional Chinese Medicine Acupuncture

Available, effectively converting low-frequency vibration into available electricity, triboelectric nanogenerator (TENG) is always research hot nowadays. However, the enhancing effect of the existing methods for the output have all sorts of drawbacks, i.e., low efficiency and unstable, and its practical applications still need to be further explored. Here, leveraging core-shell nanoparticles Ag@SiO2 doping into tribo-materials generates the surface plasmon effect to boost the output performance of the TENG. On one hand, the shell alleviated the seepage effect from conventional nanoparticles; on the other hand, the surface plasmon effect enabled the core-shell nanoparticles to further boost the output performance of TENG. We circumvent the limitations and present a TENG whose output power density can be up to 4.375 mW/cm2. Points is that this article novelty investigate the high-performance TENG applicating for traditional Chinese medicine and develop a pratical self-powered acupuncture system. This technology enables rapid, routine regulation of human health at any age, which has potential applications in nearly any setting across healthcare platforms alike

The Effect of Esmolol on Tissue Perfusion and Clinical Prognosis of Patients with Severe Sepsis: A Prospective Cohort Study

Purpose. This study was aimed at investigating the effect of esmolol on tissue perfusion and the clinical prognosis of patients with severe sepsis. Materials and Methods. One hundred fifty-one patients with severe sepsis were selected and divided into the esmolol group (n=75) or the control group (n=76), who received conventional antiseptic shock treatment. The esmolol group received a continuous infusion of esmolol via a central venous catheter, and their heart rate (HR) was maintained at 70–100 bpm over 72 hours. Results. The HR of all patients reached the target level within 72 hours of treatment for both groups. The effect of esmolol on PvaCO2 was only significant at 48 hours (P<0.05). ScvO2 increased in the esmolol group and decreased in the control group (P<0.01). Lac showed a linear downward trend over the treatment time, but the reduction was more significant in the control group at 48 hours (P<0.05) between the two groups. Kaplan-Meier analysis showed a significantly shorter duration of mechanical ventilation in the esmolol group than in the control group (P<0.05). Conclusions. Esmolol reduced the duration of mechanical ventilation in patients with severe sepsis, with no significant effect on circulatory function or tissue perfusion

Investigation of biochemical and physiological parameters of the newborn Saiga antelope (Saiga tatarica) in Gansu Province, China.

BACKGROUND:The Saiga antelope (Saiga tatarica) is a critically endangered species, and there has been limited success in restoring the population by captive breeding. This study assessed the biochemical and physiological parameters of newborn Saiga antelope to provide reference information that can be used to evaluate their health. Comparisons have been made with parameters for horses and closely related members of the Bovidae family but there are no reference values for the newborn Saiga antelope. METHODS:Biochemical and physiological parameters were measured in 61 animals. An automatic analyzer (Hitachi Ltd. 7180 Serial, Tokyo, Japan) was used to analyze the biochemical parameters, while the Coulter counter (Model ZK) was used to analyze the physiological parameters. RESULTS:The results showed that the biochemical and physiological parameters differ considerably in range. The evaluation of parameters stratified by sex showed differences. Triglyceride and LDL cholesterol concentrations among male animals were significantly higher than those in female animals, while the creatine kinase concentrations were significantly higher in females than in males. Comparing this study's results with published data for horses showed many similarities and some differences. Cholesterol, magnesium and glucose levels were similar between Saiga antelope and horses, while albumin and hematocrit levels in Saiga antelope differed from the reference values in horses. CONCLUSION:The study has shown that horses and even closely related members of the Bovidae family are not suitable references when evaluating the biochemical and physiological properties of newborn Saiga antelope. These animals have unique stressors and warrant further study to inform efforts pertaining to their care and the future sustainability of the species

Correction: Investigation of biochemical and physiological parameters of the newborn Saiga antelope (Saiga tatarica) in Gansu Province, China.

[This corrects the article DOI: 10.1371/journal.pone.0224822.]

Total Synthesis of Entecavir: A Robust Route for Pilot Production

A practical synthetic route for pilot production of entecavir is described. It is safe, robust, and scalable to kilogram scale. Starting from (<i>S</i>)-(+)-carvone, this synthetic route consists of a series of highly efficient reactions including a Favorskii rearrangement-elimination-epimerization sequence to establish the cyclopentene skeleton, the Baeyer–Villiger oxidation/rearrangement to afford the correct configuration of the secondary alcohol, and a directed homoallylic epoxidation followed by epoxide ring-opening to introduce the hydroxyl group suitable for the Mitsunobu reaction. In addition, the synthesis contains only four brief chromatographic purifications