Correspondence

Presents letters to the editor to comment on articles in previous issues. Robert Wright's article "Faux Pas," in the October 11, 1993 issue which castigates Economic Policy Institute President Jeff Faux for his criticism of the North American Free Trade Agreement (NAFTA); Robert Wright's reply; Simon Seba Montefiore's article "Mother Dolores" in the October 4, 1993 issue; Michael Kinsley's "Trading Places" in the October 4 issue in which he criticizes the Republicans who may desert the NAFTA cause; Praise for Jacob Weisberg for finding the unpublished "Blythe Spirit," by William Faulkner, in Weisberg's September 6, 1993 article

Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress.

A hallmark of cancer cells is their ability to reprogram nutrient metabolism. Thus, disruption to this phenotype is a potential avenue for anti-cancer therapy. Herein we used a phenotypic chemical library screening approach to identify molecules that disrupted nutrient metabolism (by increasing cellular oxygen consumption rate) and were toxic to cancer cells. From this screen we discovered a 1,4-Naphthoquinone (referred to as BH10) that is toxic to a broad range of cancer cell types. BH10 has improved cancer-selective toxicity compared to doxorubicin, 17-AAG, vitamin K3, and other known anti-cancer quinones. BH10 increases glucose oxidation via both mitochondrial and pentose phosphate pathways, decreases glycolysis, lowers GSH:GSSG and NAPDH/NAPD+ ratios exclusively in cancer cells, and induces necrosis. BH10 targets mitochondrial redox defence as evidenced by increased mitochondrial peroxiredoxin 3 oxidation and decreased mitochondrial aconitase activity, without changes in markers of cytosolic or nuclear damage. Over-expression of mitochondria-targeted catalase protects cells from BH10-mediated toxicity, while the thioredoxin reductase inhibitor auranofin synergistically enhances BH10-induced peroxiredoxin 3 oxidation and cytotoxicity. Overall, BH10 represents a 1,4-Naphthoquinone with an improved cancer-selective cytotoxicity profile via its mitochondrial specificity

The Deficit Commission

Earlier this year, President Barack Obama appointed a commission to reduce the long-term deficit. His endorsement, however, has unleashed demands for reductions in deficits right away. How much damage can these deficit hawks do? The author examines their incorrect assumptions.

The US economy after Reagan

Includes 3 articlesSIGLEAvailable from Bibliothek des Instituts fuer Weltwirtschaft, ZBW, Duesternbrook Weg 120, D-24105 Kiel A 180987 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

The U.S. economy after Reagan

SIGLEUuStB Koeln=38*-900106626 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman