4 research outputs found

    Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

    Get PDF
    This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

    Addressing the Professional Development Needs of Adult Numeracy Practitioners in Ireland

    No full text
    <p>The development of a numerate society is an international and national priority in education. Given such importance, there is a need for increased attention on adult education, and particularly to the availability and quality of adult numeracy education. While there has been considerable focus on mathematics teaching in general, there is a dearth of research and resources in relation to teaching adult numeracy. Consequently, there is an unmet demand for the professional development of adult numeracy practitioners with many looking for opportunities to network and further develop their practice. This study aimed to design, implement, and evaluate a professional development model that supported adult numeracy practitioners in developing the necessary skills to support their students. After an initial needs analysis, a series of six online 'Numeracy-Meets' were designed and implemented between February and May 2022. After all the Numeracy-Meets had taken place, five practitioners took part in individual semi-structured interviews to evaluate their experiences. This paper details the design, implementation, and evaluation of these Numeracy-Meets.</p&gt

    Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer

    No full text
    Small-cell lung cancer (SCLC), an aggressive neuroendocrine tumor with early dissemination and dismal prognosis, accounts for 15-20% of lung cancer cases and Ăą ̂1/4200,000 deaths each year. Most cases are inoperable, and biopsies to investigate SCLC biology are rarely obtainable. Circulating tumor cells (CTCs), which are prevalent in SCLC, present a readily accessible 'liquid biopsy'. Here we show that CTCs from patients with either chemosensitive or chemorefractory SCLC are tumorigenic in immune-compromised mice, and the resultant CTC-derived explants (CDXs) mirror the donor patient's response to platinum and etoposide chemotherapy. Genomic analysis of isolated CTCs revealed considerable similarity to the corresponding CDX. Most marked differences were observed between CDXs from patients with different clinical outcomes. These data demonstrate that CTC molecular analysis via serial blood sampling could facilitate delivery of personalized medicine for SCLC. CDXs are readily passaged, and these unique mouse models provide tractable systems for therapy testing and understanding drug resistance mechanisms. © 2014 Nature America, Inc
    corecore