Measuring the Sources of the Intergalactic Ionizing Flux

We use a wide-field (0.9 square degree) X-ray sample with optical and GALEX ultraviolet observations to measure the contribution of Active Galactic Nuclei (AGNs) to the ionizing flux as a function of redshift. Our analysis shows that the AGN contribution to the metagalactic ionizing background peaks around z=2. The measured values of the ionizing background from the AGNs are lower than previous estimates and confirm that ionization from AGNs is insufficient to maintain the observed ionization of the intergalactic medium (IGM) at z>3. We show that only sources with broad lines in their optical spectra have detectable ionizing flux and that the ionizing flux seen in an AGN is not correlated with its X-ray color. We also use the GALEX observations of the GOODS-N region to place a 2-sigma upper limit of 0.008 on the average ionization fraction fnu(700 A)/fnu(1500 A) for 626 UV selected galaxies in the redshift range z=0.9-1.4. We then use this limit to estimate an upper bound to the galaxy contribution in the redshift range z=0-5. If the z~1.15 ionization fraction is appropriate for higher redshift galaxies, then contributions from the galaxy population are also too low to account for the IGM ionization at the highest redshifts (z>4).Comment: 15 pages, Accepted by The Astrophysical Journa

Arachidonic acid-induced release of calcium in permeabilized human neutrophils

AbstractThe addition of arachidonic acid to a suspension of digitonin-permeabilized human neutrophils was found to induce, in a dose-dependent manner (ED50 about 15 μM), the release of calcium from internal stores. Arachidic acid was without effect, while linoleic acid and linolenic acid were (on a concentration basis) at least 5-times less active than arachidonic acid. The activity of arachidonic acid appears to be due to the fatty acid itself and not to one of its metabolites. The pool of calcium mobilized by arachidonic acid includes that sensitive to inositol 1,4,5-trisphosphate. These results demonstrate a significant intracellular role for arachidonic acid at the level of the internal mobilization of calcium in human neutrophils

On The Nature of Variations in the Measured Star Formation Efficiency of Molecular Clouds

Measurements of the star formation efficiency (SFE) of giant molecular clouds (GMCs) in the Milky Way generally show a large scatter, which could be intrinsic or observational. We use magnetohydrodynamic simulations of GMCs (including feedback) to forward-model the relationship between the true GMC SFE and observational proxies. We show that individual GMCs trace broad ranges of observed SFE throughout collapse, star formation, and disruption. Low measured SFEs (<<1%) are "real" but correspond to early stages, the true "per-freefall" SFE where most stars actually form can be much larger. Very high (>>10%) values are often artificially enhanced by rapid gas dispersal. Simulations including stellar feedback reproduce observed GMC-scale SFEs, but simulations without feedback produce 20x larger SFEs. Radiative feedback dominates among mechanisms simulated. An anticorrelation of SFE with cloud mass is shown to be an observational artifact. We also explore individual dense "clumps" within GMCs and show that (with feedback) their bulk properties agree well with observations. Predicted SFEs within the dense clumps are ~2x larger than observed, possibly indicating physics other than feedback from massive (main sequence) stars is needed to regulate their collapse.Comment: Fixed typo in the arXiv abstrac

The Origin and Evolution of the Galaxy Mass-Metallicity Relation

We use high-resolution cosmological zoom-in simulations from the Feedback in Realistic Environment (FIRE) project to study the galaxy mass-metallicity relations (MZR) from z=0-6. These simulations include explicit models of the multi-phase ISM, star formation, and stellar feedback. The simulations cover halo masses Mhalo=10^9-10^13 Msun and stellar mass Mstar=10^4-10^11 Msun at z=0 and have been shown to produce many observed galaxy properties from z=0-6. For the first time, our simulations agree reasonably well with the observed mass-metallicity relations at z=0-3 for a broad range of galaxy masses. We predict the evolution of the MZR from z=0-6 as log(Zgas/Zsun)=12+log(O/H)-9.0=0.35[log(Mstar/Msun)-10]+0.93 exp(-0.43 z)-1.05 and log(Zstar/Zsun)=[Fe/H]-0.2=0.40[log(Mstar/Msun)-10]+0.67 exp(-0.50 z)-1.04, for gas-phase and stellar metallicity, respectively. Our simulations suggest that the evolution of MZR is associated with the evolution of stellar/gas mass fractions at different redshifts, indicating the existence of a universal metallicity relation between stellar mass, gas mass, and metallicities. In our simulations, galaxies above Mstar=10^6 Msun are able to retain a large fraction of their metals inside the halo, because metal-rich winds fail to escape completely and are recycled into the galaxy. This resolves a long-standing discrepancy between "sub-grid" wind models (and semi-analytic models) and observations, where common sub-grid models cannot simultaneously reproduce the MZR and the stellar mass functions.Comment: 17 pages, 14 figures, re-submitted to MNRAS after revisions on referee comment